Quantitative assessment of gliomas by proton magnetic resonance spectroscopy

Shinya Oshiro, Hitoshi Tsugu, Fuminari Komatsu, Hiroshi Abe, Hirokazu Onishi, Tadahiro Ohmura, Mitsutoshi Iwaasa, Seisaburo Sakamoto, Takeo Fukushima

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)

Abstract

Background: Advanced magnetic resonance (MR) techniques provide physiological and metabolic information that complements the anatomical information available from conventional MR imaging. The purpose of this study was to evaluate the clinical usefulness of proton MR spectroscopy ( 1H-MRS) in preoperative quantitative assessment of intracranial gliomas. Patients and Methods: Eight patients with histologically verified gliomas, comprising 2 cases with glioblastoma multiforme (GBM, grade 4), 5 cases with anaplastic oligodendroglioma (AO, grade 3; high-grade glioma), and 1 case with fibrillary astrocytoma (FA, grade 2; low-grade glioma) were evaluated using the 1H-MRS protocol following conventional MR imaging, diffusion-weighted imaging (DWI), and perfusion-weighted imaging (PWI) preoperatively. Results: High-grade gliomas tended to demonstrate signal hyperintensity by DWI and higher relative cerebral blood volume (rCBV) by PWI. Increased ratios of choline (Cho) to N-acetylaspartate (NAA) (Cho/NAA) and Cho to creatine (Cr) (Cho/Cr) correlated highly with tumor malignancy. The presence of lactate and lipid was predominately detected in patients with high-grade glioma. Conclusion: The combination of multiple MR parameters, based on DWI, PWI and 1H-MRS, appears valuable for preoperatively predicting the degree of malignancy in glioma.

Original languageEnglish
Pages (from-to)3757-3763
Number of pages7
JournalAnticancer research
Volume27
Issue number6 A
Publication statusPublished - 11-2007
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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