Quantitative assessment with intracoronary ultrasound of the mechanisms of restenosis after percutaneous transluminal coronary angioplasty and directional coronary atherectomy

Carlo Di Mario, Robert Gil, Edoardo Camenzind, Yukio Ozaki, Clemens von Birgelen, Victor Umans, Peter de Jaegere, Pim J. de Feyter, Jos R.T.C. Roelandt, Patrick W. Serruys

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Abstract

The mechanisms of immediate and late changes after percutaneous transluminal coronary angioplasty (PTCA) and directional coronary atherectomy (DCA) were assessed by serial ultrasound imaging in 18 patients treated with PTCA and 16 treated with DCA before, immediately after, and 6 months after coronary interventions. A reduction in plaque area was the main operative mechanism of DCA, explaining 66% of lumen enlargement. In the PTCA group, the increase in lumen area was the result of a more balanced combination of plaque reduction (52% of lumen increase) and increase in total lumen area (48%); p < 0.05 versus DCA. In the PTCA group, this last mechanism was prevalent (p < 0.05) in the lesions showing wall fracture or dissection after treatment and in the lesions with a mixed or calcific composition. In the PTCA group, concentric lesions showed a greater plaque compression than eccentric lesions (p < 0.02). Plaque increase was responsible for 92% and 32% of the late lumen loss after DCA and after PTCA, respectively (p < 0.05). In PTCA patients, a chronic reduction in total vessel area was the main operative mechanism of lumen reduction (67%) and was prevalent in lesions with a mixed or calcific composition (p < 0.05).

Original languageEnglish
Pages (from-to)772-777
Number of pages6
JournalThe American Journal of Cardiology
Volume75
Issue number12
DOIs
Publication statusPublished - 15-04-1995
Externally publishedYes

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Coronary Atherectomy
Coronary Balloon Angioplasty
Dissection
Ultrasonography

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Di Mario, Carlo ; Gil, Robert ; Camenzind, Edoardo ; Ozaki, Yukio ; von Birgelen, Clemens ; Umans, Victor ; de Jaegere, Peter ; de Feyter, Pim J. ; Roelandt, Jos R.T.C. ; Serruys, Patrick W. / Quantitative assessment with intracoronary ultrasound of the mechanisms of restenosis after percutaneous transluminal coronary angioplasty and directional coronary atherectomy. In: The American Journal of Cardiology. 1995 ; Vol. 75, No. 12. pp. 772-777.
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abstract = "The mechanisms of immediate and late changes after percutaneous transluminal coronary angioplasty (PTCA) and directional coronary atherectomy (DCA) were assessed by serial ultrasound imaging in 18 patients treated with PTCA and 16 treated with DCA before, immediately after, and 6 months after coronary interventions. A reduction in plaque area was the main operative mechanism of DCA, explaining 66{\%} of lumen enlargement. In the PTCA group, the increase in lumen area was the result of a more balanced combination of plaque reduction (52{\%} of lumen increase) and increase in total lumen area (48{\%}); p < 0.05 versus DCA. In the PTCA group, this last mechanism was prevalent (p < 0.05) in the lesions showing wall fracture or dissection after treatment and in the lesions with a mixed or calcific composition. In the PTCA group, concentric lesions showed a greater plaque compression than eccentric lesions (p < 0.02). Plaque increase was responsible for 92{\%} and 32{\%} of the late lumen loss after DCA and after PTCA, respectively (p < 0.05). In PTCA patients, a chronic reduction in total vessel area was the main operative mechanism of lumen reduction (67{\%}) and was prevalent in lesions with a mixed or calcific composition (p < 0.05).",
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Quantitative assessment with intracoronary ultrasound of the mechanisms of restenosis after percutaneous transluminal coronary angioplasty and directional coronary atherectomy. / Di Mario, Carlo; Gil, Robert; Camenzind, Edoardo; Ozaki, Yukio; von Birgelen, Clemens; Umans, Victor; de Jaegere, Peter; de Feyter, Pim J.; Roelandt, Jos R.T.C.; Serruys, Patrick W.

In: The American Journal of Cardiology, Vol. 75, No. 12, 15.04.1995, p. 772-777.

Research output: Contribution to journalArticle

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AU - Di Mario, Carlo

AU - Gil, Robert

AU - Camenzind, Edoardo

AU - Ozaki, Yukio

AU - von Birgelen, Clemens

AU - Umans, Victor

AU - de Jaegere, Peter

AU - de Feyter, Pim J.

AU - Roelandt, Jos R.T.C.

AU - Serruys, Patrick W.

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N2 - The mechanisms of immediate and late changes after percutaneous transluminal coronary angioplasty (PTCA) and directional coronary atherectomy (DCA) were assessed by serial ultrasound imaging in 18 patients treated with PTCA and 16 treated with DCA before, immediately after, and 6 months after coronary interventions. A reduction in plaque area was the main operative mechanism of DCA, explaining 66% of lumen enlargement. In the PTCA group, the increase in lumen area was the result of a more balanced combination of plaque reduction (52% of lumen increase) and increase in total lumen area (48%); p < 0.05 versus DCA. In the PTCA group, this last mechanism was prevalent (p < 0.05) in the lesions showing wall fracture or dissection after treatment and in the lesions with a mixed or calcific composition. In the PTCA group, concentric lesions showed a greater plaque compression than eccentric lesions (p < 0.02). Plaque increase was responsible for 92% and 32% of the late lumen loss after DCA and after PTCA, respectively (p < 0.05). In PTCA patients, a chronic reduction in total vessel area was the main operative mechanism of lumen reduction (67%) and was prevalent in lesions with a mixed or calcific composition (p < 0.05).

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