Quantitative measurement of regional cerebral blood flow using N- isopropyl-(iodine-123)p-iodoamphetamine and single-photon emission computed tomography

G. Takeshita, H. Maeda, K. Nakane, Hiroshi Toyama, E. Sakakibara, S. Komai, A. Takeuchi, S. Koga, M. Ono, T. Nakagawa

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

We have developed a quantitative method of measuring regional cerebral blood flow (rCBF) by using N-isopropyl-(iodine-123)p-iodoamphetamine and single-photon emission computed tomography (SPECT). Twenty-five dynamic SPECT images (24 sec/scan) were collected immediately after tracer injection using a ring-type SPECT system and the accumulation curve (C(t)) was obtained. The time-activity curve corresponding to the arterial blood activity curve was used as B(t). The latter curve was calculated from the lung time-activity curve monitored during scanning and corrected by the actual activity obtained by one-point blood sampling 5 min after tracer injection. The octanol extraction ratio during scanning was considered to be constant and taken as the value measured 5 min after tracer injection (E). The uptake constant (K) per pixel was calculated by the least squares fitting method as the slope of the linear relationship in which C(t)/E x B(t) was plotted against E x ∫(o)/(t)B(τ)dτ/E x B(t). Functional maps of rCBF values were obtained on a 64 x 64 matrix by calculating the uptake constant per pixel and the cross calibration factor (CF) between the SPECT system and a well counter (rCBF = K · CF x 100).

Original languageEnglish
Pages (from-to)1741-1749
Number of pages9
JournalJournal of Nuclear Medicine
Volume33
Issue number10
Publication statusPublished - 01-01-1992

Fingerprint

Cerebrovascular Circulation
Iofetamine
Regional Blood Flow
Single-Photon Emission-Computed Tomography
Calibration
Injections
Octanols
Least-Squares Analysis
Lung

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

Cite this

Takeshita, G. ; Maeda, H. ; Nakane, K. ; Toyama, Hiroshi ; Sakakibara, E. ; Komai, S. ; Takeuchi, A. ; Koga, S. ; Ono, M. ; Nakagawa, T. / Quantitative measurement of regional cerebral blood flow using N- isopropyl-(iodine-123)p-iodoamphetamine and single-photon emission computed tomography. In: Journal of Nuclear Medicine. 1992 ; Vol. 33, No. 10. pp. 1741-1749.
@article{d745224c3b3b43269ed6018f4b3df689,
title = "Quantitative measurement of regional cerebral blood flow using N- isopropyl-(iodine-123)p-iodoamphetamine and single-photon emission computed tomography",
abstract = "We have developed a quantitative method of measuring regional cerebral blood flow (rCBF) by using N-isopropyl-(iodine-123)p-iodoamphetamine and single-photon emission computed tomography (SPECT). Twenty-five dynamic SPECT images (24 sec/scan) were collected immediately after tracer injection using a ring-type SPECT system and the accumulation curve (C(t)) was obtained. The time-activity curve corresponding to the arterial blood activity curve was used as B(t). The latter curve was calculated from the lung time-activity curve monitored during scanning and corrected by the actual activity obtained by one-point blood sampling 5 min after tracer injection. The octanol extraction ratio during scanning was considered to be constant and taken as the value measured 5 min after tracer injection (E). The uptake constant (K) per pixel was calculated by the least squares fitting method as the slope of the linear relationship in which C(t)/E x B(t) was plotted against E x ∫(o)/(t)B(τ)dτ/E x B(t). Functional maps of rCBF values were obtained on a 64 x 64 matrix by calculating the uptake constant per pixel and the cross calibration factor (CF) between the SPECT system and a well counter (rCBF = K · CF x 100).",
author = "G. Takeshita and H. Maeda and K. Nakane and Hiroshi Toyama and E. Sakakibara and S. Komai and A. Takeuchi and S. Koga and M. Ono and T. Nakagawa",
year = "1992",
month = "1",
day = "1",
language = "English",
volume = "33",
pages = "1741--1749",
journal = "Journal of Nuclear Medicine",
issn = "0161-5505",
publisher = "Society of Nuclear Medicine Inc.",
number = "10",

}

Takeshita, G, Maeda, H, Nakane, K, Toyama, H, Sakakibara, E, Komai, S, Takeuchi, A, Koga, S, Ono, M & Nakagawa, T 1992, 'Quantitative measurement of regional cerebral blood flow using N- isopropyl-(iodine-123)p-iodoamphetamine and single-photon emission computed tomography', Journal of Nuclear Medicine, vol. 33, no. 10, pp. 1741-1749.

Quantitative measurement of regional cerebral blood flow using N- isopropyl-(iodine-123)p-iodoamphetamine and single-photon emission computed tomography. / Takeshita, G.; Maeda, H.; Nakane, K.; Toyama, Hiroshi; Sakakibara, E.; Komai, S.; Takeuchi, A.; Koga, S.; Ono, M.; Nakagawa, T.

In: Journal of Nuclear Medicine, Vol. 33, No. 10, 01.01.1992, p. 1741-1749.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Quantitative measurement of regional cerebral blood flow using N- isopropyl-(iodine-123)p-iodoamphetamine and single-photon emission computed tomography

AU - Takeshita, G.

AU - Maeda, H.

AU - Nakane, K.

AU - Toyama, Hiroshi

AU - Sakakibara, E.

AU - Komai, S.

AU - Takeuchi, A.

AU - Koga, S.

AU - Ono, M.

AU - Nakagawa, T.

PY - 1992/1/1

Y1 - 1992/1/1

N2 - We have developed a quantitative method of measuring regional cerebral blood flow (rCBF) by using N-isopropyl-(iodine-123)p-iodoamphetamine and single-photon emission computed tomography (SPECT). Twenty-five dynamic SPECT images (24 sec/scan) were collected immediately after tracer injection using a ring-type SPECT system and the accumulation curve (C(t)) was obtained. The time-activity curve corresponding to the arterial blood activity curve was used as B(t). The latter curve was calculated from the lung time-activity curve monitored during scanning and corrected by the actual activity obtained by one-point blood sampling 5 min after tracer injection. The octanol extraction ratio during scanning was considered to be constant and taken as the value measured 5 min after tracer injection (E). The uptake constant (K) per pixel was calculated by the least squares fitting method as the slope of the linear relationship in which C(t)/E x B(t) was plotted against E x ∫(o)/(t)B(τ)dτ/E x B(t). Functional maps of rCBF values were obtained on a 64 x 64 matrix by calculating the uptake constant per pixel and the cross calibration factor (CF) between the SPECT system and a well counter (rCBF = K · CF x 100).

AB - We have developed a quantitative method of measuring regional cerebral blood flow (rCBF) by using N-isopropyl-(iodine-123)p-iodoamphetamine and single-photon emission computed tomography (SPECT). Twenty-five dynamic SPECT images (24 sec/scan) were collected immediately after tracer injection using a ring-type SPECT system and the accumulation curve (C(t)) was obtained. The time-activity curve corresponding to the arterial blood activity curve was used as B(t). The latter curve was calculated from the lung time-activity curve monitored during scanning and corrected by the actual activity obtained by one-point blood sampling 5 min after tracer injection. The octanol extraction ratio during scanning was considered to be constant and taken as the value measured 5 min after tracer injection (E). The uptake constant (K) per pixel was calculated by the least squares fitting method as the slope of the linear relationship in which C(t)/E x B(t) was plotted against E x ∫(o)/(t)B(τ)dτ/E x B(t). Functional maps of rCBF values were obtained on a 64 x 64 matrix by calculating the uptake constant per pixel and the cross calibration factor (CF) between the SPECT system and a well counter (rCBF = K · CF x 100).

UR - http://www.scopus.com/inward/record.url?scp=0026672408&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026672408&partnerID=8YFLogxK

M3 - Article

VL - 33

SP - 1741

EP - 1749

JO - Journal of Nuclear Medicine

JF - Journal of Nuclear Medicine

SN - 0161-5505

IS - 10

ER -