Quantitative measurement of regional cerebral blood flow using N- isopropyl-(iodine-123)p-iodoamphetamine and single-photon emission computed tomography

G. Takeshita, H. Maeda, K. Nakane, Hiroshi Toyama, E. Sakakibara, S. Komai, A. Takeuchi, S. Koga, M. Ono, T. Nakagawa

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Abstract

We have developed a quantitative method of measuring regional cerebral blood flow (rCBF) by using N-isopropyl-(iodine-123)p-iodoamphetamine and single-photon emission computed tomography (SPECT). Twenty-five dynamic SPECT images (24 sec/scan) were collected immediately after tracer injection using a ring-type SPECT system and the accumulation curve (C(t)) was obtained. The time-activity curve corresponding to the arterial blood activity curve was used as B(t). The latter curve was calculated from the lung time-activity curve monitored during scanning and corrected by the actual activity obtained by one-point blood sampling 5 min after tracer injection. The octanol extraction ratio during scanning was considered to be constant and taken as the value measured 5 min after tracer injection (E). The uptake constant (K) per pixel was calculated by the least squares fitting method as the slope of the linear relationship in which C(t)/E x B(t) was plotted against E x ∫(o)/(t)B(τ)dτ/E x B(t). Functional maps of rCBF values were obtained on a 64 x 64 matrix by calculating the uptake constant per pixel and the cross calibration factor (CF) between the SPECT system and a well counter (rCBF = K · CF x 100).

Original languageEnglish
Pages (from-to)1741-1749
Number of pages9
JournalJournal of Nuclear Medicine
Volume33
Issue number10
Publication statusPublished - 01-01-1992

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

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    Takeshita, G., Maeda, H., Nakane, K., Toyama, H., Sakakibara, E., Komai, S., Takeuchi, A., Koga, S., Ono, M., & Nakagawa, T. (1992). Quantitative measurement of regional cerebral blood flow using N- isopropyl-(iodine-123)p-iodoamphetamine and single-photon emission computed tomography. Journal of Nuclear Medicine, 33(10), 1741-1749.