Quantitative measurement of regional cerebral blood flow with I-123 IMP SPECT: A correction of the microsphere model by global extraction between artery and internal jugular vein

Gen Takeshita, Hiroshi Toyama, Kaori Nakane, Hisato Maeda, Kazuhiro Katada, Akira Takeuchi, Sukehiko Koga

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Abstract

Quantitative measurements of regional cerebral blood flow with N-isopropyl-(Iodine 123)p-iodoamphetamine (I-123 IMP) as a microsphere model were performed in forty cases. The regional cerebral blood flow values obtained with I-123 IMP were slightly underestimated compared with those of Xe-133 inhalation methods (y=0.90x-2.1, r=0.85, p< 0.01). After correction by global extraction (87 %) between the artery and internal jugular vein, which was measured in four patients by means of a catheter technique, the underestimation of the values obtained with I-123 IMP was improved (y=1.0x-2.4, r=0.85, p< 0.01). Several problems in the accurate quantitative measurement of regional cerebral blood flow with I-123 IMP are discussed.

Original languageEnglish
Pages (from-to)145-148
Number of pages4
JournalAnnals of Nuclear Medicine
Volume5
Issue number4
DOIs
Publication statusPublished - 01-12-1991

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All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

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