TY - JOUR
T1 - Radial maze performance, open-field and elevated plus-maze behaviors in Fyn-kinase deficient mice
T2 - Further evidence for increased fearfulness
AU - Miyakawa, Tsuyoshi
AU - Yagi, Takeshi
AU - Kagiyama, Akira
AU - Niki, Hiroaki
N1 - Funding Information:
The authors wish to thank Drs. Shinichi Aizawa and Yoji Ikawa for giving us their permissiont o use the Fyn deficientm ice in the presents tudy.Thanks are also due to K. Kashiwagi, A. Nakagami,K . Tateishi for their help in animal care and data analysis.W e acknowledgeD r. James Downing of University of London for his help in improving the English. This work was supportedi n part by a Grant-in-Aid for CooperativeR esearchn o. 05301011t o H. Niki for 1993-1994fr om the JapaneseM inistry of Education, Sciencea nd Culture.
PY - 1996/4
Y1 - 1996/4
N2 - Fyn-deficient mice produced by inserting the β-galactosidase gene (lacZ) into the fyn gene locus were tested in a radial maze, an open field and an elevated plus-maze. In the radial maze, the homozygous Fyn-deficient (fyn(z)/fyn(z)) mice showed no impairment in spatial learning, although they showed a stronger avoidance tendency for those arms located closer to the experimenter during pretraining (adaptation). In the open-field test, the fyn(z)/fyn(z) mice defecated more frequently in the bright condition than did the +/fyn(z) mice, and they were less active during the first 10-min test period than the +/fyn(z) mice. In addition, the temporal pattern of locomotor activity for fyn(z)/fyn(z) mice was altered by changing the illumination while the pattern for +/fyn(z) mice remained relatively unchanged. Scores reflecting the fear-response in the elevated plus-maze were higher in the fyn(z)/fyn(z) mice. These results indicate that Fyn deficiency increased fear-response, but did not impair spatial learning in the radial maze. It is suggested that we should take account of effects of emotional factors in the learning experiment using mutant mice.
AB - Fyn-deficient mice produced by inserting the β-galactosidase gene (lacZ) into the fyn gene locus were tested in a radial maze, an open field and an elevated plus-maze. In the radial maze, the homozygous Fyn-deficient (fyn(z)/fyn(z)) mice showed no impairment in spatial learning, although they showed a stronger avoidance tendency for those arms located closer to the experimenter during pretraining (adaptation). In the open-field test, the fyn(z)/fyn(z) mice defecated more frequently in the bright condition than did the +/fyn(z) mice, and they were less active during the first 10-min test period than the +/fyn(z) mice. In addition, the temporal pattern of locomotor activity for fyn(z)/fyn(z) mice was altered by changing the illumination while the pattern for +/fyn(z) mice remained relatively unchanged. Scores reflecting the fear-response in the elevated plus-maze were higher in the fyn(z)/fyn(z) mice. These results indicate that Fyn deficiency increased fear-response, but did not impair spatial learning in the radial maze. It is suggested that we should take account of effects of emotional factors in the learning experiment using mutant mice.
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U2 - 10.1016/0169-328X(95)00300-H
DO - 10.1016/0169-328X(95)00300-H
M3 - Article
C2 - 8738145
AN - SCOPUS:0029887733
SN - 0169-328X
VL - 37
SP - 145
EP - 150
JO - Molecular Brain Research
JF - Molecular Brain Research
IS - 1-2
ER -