Radiofrequency ablation with and without balloon occlusion of the renal artery: An experimental study in porcine kidneys

Zentaro Kariya, Koichiro Yamakado, Atsuhiro Nakatuka, Mitsutoshi Onoda, Shigeki Kobayasi, Kan Takeda

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

PURPOSE: To compare thermal lesion volumes and associated renal damage (other than thermal lesions) when radiofrequency (RF) ablation is performed with and without balloon occlusion of the renal artery in normal porcine kidneys. MATERIALS AND METHODS: RF ablation was performed in six pigs. An electrode with eight circumferential prongs arranged in a circle 20 mm in diameter was inserted into the lower pole of the kidney. In each animal, renal ablation was performed with balloon occlusion of the renal artery in one kidney and without balloon occlusion in the contralateral kidney. The volume of the thermal lesion and associated renal damage other than the thermal lesion were compared by angiography and histology between the groups of kidneys ablated with and without arterial occlusion. The volume of thermal lesion was measured by tracing the thermal lesions of sliced kidneys and multiplying each area by the slice thickness (5 mm). RESULTS: Renal ablation with arterial occlusion consistently created nearly spherical thermal lesions with a mean volume of 5,399 mm3 ± 902. RF ablation without arterial occlusion, conversely, created irregular, mushroom-shaped thermal lesions limited to the region around the prongs and shaft of the electrode, with a mean volume of 2,759 mm3 ± 1,069 (P < .001). Renal arteriography showed occlusion of interlobar arteries penetrating the thermal lesions and perfusion defects peripheral to the thermal lesions immediately after RF ablation. Perfusion defects were larger in kidneys ablated with arterial occlusion than in those ablated without arterial occlusion (1,499 cm2 ± 354 vs 499 cm2 ± 352; P < .001). CONCLUSIONS: Renal RF ablation with arterial occlusion consistently provides larger thermal lesions than ablation without arterial occlusion does, but it induces renal infarction peripheral to the thermal lesion.

Original languageEnglish
Pages (from-to)241-245
Number of pages5
JournalJournal of Vascular and Interventional Radiology
Volume14
Issue number2 I
DOIs
Publication statusPublished - 01-02-2003
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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