RANTES promoter genotype and gastric cancer risk in a Japanese population

Tomomitsu Tahara, Omoyuki Shibata, Masakatsu Nakamura, Hiromi Yamashita, Daisuke Yoshioka, Ichiro Hirata, Tomiyasu Arisawa

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: A complex interaction of genetic and environmental factors is relevant in gastric carcinogenesis. Previous studies reported that the expression of RANTES is enhanced in Helicobacter pylori-infected gastric mucosa. Elevated serum level of RANTES in gastric cancer patients was also reported. We aimed to clarify the effect of RANTES promoter polymorphism on the risk of gastric cancer (GC) in a Japanese population. Materials and Methods: A total of 191 GC and 335 non-cancer patients including H. pylori-positive gastritis (n=180) and H. pylori- negative healthy stomach (n=155) were genotyped for polymorphisms at -28 C/G in the RANTES gene promoter region. Results: RANTES promoter genotype distributions were not significantly different among GC, overall non-cancer patients, healthy stomach and gastritis. In the comparison of genotype frequency between GC and healthy stomach, only a weak correlation was found between -28G/G genotype and GC in individuals more than 70 years of age (odds ratio (OR)=7.65, 95% confidence interval (CI)=0.78-75.0, p=0.07), with advanced stage (OR=6.58, 95% CI=0.72-59.77, p=0.07), lymph node metastasis (OR=7.20, 95% CI=0.79-65.46, p=0.06) and peritoneal dissemination (OR=10.93, 95% CI=0.96-124.64, p=0.07). Conclusion: The effect of -28 C/G polymorphism in the RANTES gene promoter on GC development may not to be very strong. The role of RANTES promoter polymorphism in gastric carcinogenesis needs further evaluation.

Original languageEnglish
Pages (from-to)4265-4269
Number of pages5
JournalAnticancer Research
Volume29
Issue number10
Publication statusPublished - 01-10-2009

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Chemokine CCL5
Stomach Neoplasms
Genotype
Population
Stomach
Odds Ratio
Helicobacter pylori
Confidence Intervals
Gastritis
Carcinogenesis
Gastric Mucosa
Genetic Promoter Regions
Genes
Lymph Nodes
Neoplasm Metastasis

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Tahara, T., Shibata, O., Nakamura, M., Yamashita, H., Yoshioka, D., Hirata, I., & Arisawa, T. (2009). RANTES promoter genotype and gastric cancer risk in a Japanese population. Anticancer Research, 29(10), 4265-4269.
Tahara, Tomomitsu ; Shibata, Omoyuki ; Nakamura, Masakatsu ; Yamashita, Hiromi ; Yoshioka, Daisuke ; Hirata, Ichiro ; Arisawa, Tomiyasu. / RANTES promoter genotype and gastric cancer risk in a Japanese population. In: Anticancer Research. 2009 ; Vol. 29, No. 10. pp. 4265-4269.
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abstract = "Background: A complex interaction of genetic and environmental factors is relevant in gastric carcinogenesis. Previous studies reported that the expression of RANTES is enhanced in Helicobacter pylori-infected gastric mucosa. Elevated serum level of RANTES in gastric cancer patients was also reported. We aimed to clarify the effect of RANTES promoter polymorphism on the risk of gastric cancer (GC) in a Japanese population. Materials and Methods: A total of 191 GC and 335 non-cancer patients including H. pylori-positive gastritis (n=180) and H. pylori- negative healthy stomach (n=155) were genotyped for polymorphisms at -28 C/G in the RANTES gene promoter region. Results: RANTES promoter genotype distributions were not significantly different among GC, overall non-cancer patients, healthy stomach and gastritis. In the comparison of genotype frequency between GC and healthy stomach, only a weak correlation was found between -28G/G genotype and GC in individuals more than 70 years of age (odds ratio (OR)=7.65, 95{\%} confidence interval (CI)=0.78-75.0, p=0.07), with advanced stage (OR=6.58, 95{\%} CI=0.72-59.77, p=0.07), lymph node metastasis (OR=7.20, 95{\%} CI=0.79-65.46, p=0.06) and peritoneal dissemination (OR=10.93, 95{\%} CI=0.96-124.64, p=0.07). Conclusion: The effect of -28 C/G polymorphism in the RANTES gene promoter on GC development may not to be very strong. The role of RANTES promoter polymorphism in gastric carcinogenesis needs further evaluation.",
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Tahara, T, Shibata, O, Nakamura, M, Yamashita, H, Yoshioka, D, Hirata, I & Arisawa, T 2009, 'RANTES promoter genotype and gastric cancer risk in a Japanese population', Anticancer Research, vol. 29, no. 10, pp. 4265-4269.

RANTES promoter genotype and gastric cancer risk in a Japanese population. / Tahara, Tomomitsu; Shibata, Omoyuki; Nakamura, Masakatsu; Yamashita, Hiromi; Yoshioka, Daisuke; Hirata, Ichiro; Arisawa, Tomiyasu.

In: Anticancer Research, Vol. 29, No. 10, 01.10.2009, p. 4265-4269.

Research output: Contribution to journalArticle

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T1 - RANTES promoter genotype and gastric cancer risk in a Japanese population

AU - Tahara, Tomomitsu

AU - Shibata, Omoyuki

AU - Nakamura, Masakatsu

AU - Yamashita, Hiromi

AU - Yoshioka, Daisuke

AU - Hirata, Ichiro

AU - Arisawa, Tomiyasu

PY - 2009/10/1

Y1 - 2009/10/1

N2 - Background: A complex interaction of genetic and environmental factors is relevant in gastric carcinogenesis. Previous studies reported that the expression of RANTES is enhanced in Helicobacter pylori-infected gastric mucosa. Elevated serum level of RANTES in gastric cancer patients was also reported. We aimed to clarify the effect of RANTES promoter polymorphism on the risk of gastric cancer (GC) in a Japanese population. Materials and Methods: A total of 191 GC and 335 non-cancer patients including H. pylori-positive gastritis (n=180) and H. pylori- negative healthy stomach (n=155) were genotyped for polymorphisms at -28 C/G in the RANTES gene promoter region. Results: RANTES promoter genotype distributions were not significantly different among GC, overall non-cancer patients, healthy stomach and gastritis. In the comparison of genotype frequency between GC and healthy stomach, only a weak correlation was found between -28G/G genotype and GC in individuals more than 70 years of age (odds ratio (OR)=7.65, 95% confidence interval (CI)=0.78-75.0, p=0.07), with advanced stage (OR=6.58, 95% CI=0.72-59.77, p=0.07), lymph node metastasis (OR=7.20, 95% CI=0.79-65.46, p=0.06) and peritoneal dissemination (OR=10.93, 95% CI=0.96-124.64, p=0.07). Conclusion: The effect of -28 C/G polymorphism in the RANTES gene promoter on GC development may not to be very strong. The role of RANTES promoter polymorphism in gastric carcinogenesis needs further evaluation.

AB - Background: A complex interaction of genetic and environmental factors is relevant in gastric carcinogenesis. Previous studies reported that the expression of RANTES is enhanced in Helicobacter pylori-infected gastric mucosa. Elevated serum level of RANTES in gastric cancer patients was also reported. We aimed to clarify the effect of RANTES promoter polymorphism on the risk of gastric cancer (GC) in a Japanese population. Materials and Methods: A total of 191 GC and 335 non-cancer patients including H. pylori-positive gastritis (n=180) and H. pylori- negative healthy stomach (n=155) were genotyped for polymorphisms at -28 C/G in the RANTES gene promoter region. Results: RANTES promoter genotype distributions were not significantly different among GC, overall non-cancer patients, healthy stomach and gastritis. In the comparison of genotype frequency between GC and healthy stomach, only a weak correlation was found between -28G/G genotype and GC in individuals more than 70 years of age (odds ratio (OR)=7.65, 95% confidence interval (CI)=0.78-75.0, p=0.07), with advanced stage (OR=6.58, 95% CI=0.72-59.77, p=0.07), lymph node metastasis (OR=7.20, 95% CI=0.79-65.46, p=0.06) and peritoneal dissemination (OR=10.93, 95% CI=0.96-124.64, p=0.07). Conclusion: The effect of -28 C/G polymorphism in the RANTES gene promoter on GC development may not to be very strong. The role of RANTES promoter polymorphism in gastric carcinogenesis needs further evaluation.

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Tahara T, Shibata O, Nakamura M, Yamashita H, Yoshioka D, Hirata I et al. RANTES promoter genotype and gastric cancer risk in a Japanese population. Anticancer Research. 2009 Oct 1;29(10):4265-4269.