Rapid Diagnostic Test Value and Implementation in Antimicrobial Stewardship Across Low-to-Middle and High-Income Countries: A Mixed-Methods Review

Luke S.P. Moore, Maria Virginia Villegas, Eric Wenzler, Timothy M. Rawson, Rita O. Oladele, Yohei Doi, Anucha Apisarnthanarak

Research output: Contribution to journalComment/debatepeer-review

3 Citations (Scopus)

Abstract

Despite technological advancements in infectious disease rapid diagnostic tests (RDTs) and use to direct therapy at the per-patient level, RDT utilisation in antimicrobial stewardship programmes (ASPs) is variable across low-to-middle income and high-income countries. Key insights from a panel of seven infectious disease experts from Colombia, Japan, Nigeria, Thailand, the UK, and the USA, combined with evidence from a literature review, were used to assess the value of RDTs in ASPs. From this, a value framework is proposed which aims to define the benefits of RDT use in ASPs, separate from per-patient benefits. Expert insights highlight that, to realise the value of RDTs within ASPs, effective implementation is key; actionable advice for choosing an RDT is proposed. Experts advocate the inclusion of RDTs in the World Health Organization Model List of essential in vitro diagnostics and in iterative development of national action plans.

Original languageEnglish
Pages (from-to)1445-1463
Number of pages19
JournalInfectious Diseases and Therapy
Volume12
Issue number6
DOIs
Publication statusPublished - 06-2023

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases

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