Rapidly developing weakness mimicking Guillain-Barré syndrome in beriberi neuropathy: Two case reports

Haruki Koike, Shinji Ito, Saori Morozumi, Yuichi Kawagashira, Masahiro Iijima, Naoki Hattori, Fumiaki Tanaka, Gen Sobue

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Objective: We examined the diagnostic difficulty in thiamine deficiency. Methods: We report on two patients with polyneuropathy associated with thiamine deficiency (i.e., beriberi neuropathy) that presented with acute motor symptoms mimicking Guillain-Barré syndrome. Results: The cause of the thiamine deficiency was associated with gastrectomy to treat cancer in a 46-y-old man and with dietary imbalance in a 33-y-old man. The thiamine deficiency was not related to alcohol intake in either patient. In both patients, the upper and lower extremities showed a rapidly progressive weakness over the course of 1 mo. Muscle weakness in the first patient progressed even after admission to the hospital, and urinary retention, Wernicke's encephalopathy, lactic acidosis, paralytic ileus, and heart failure appeared subsequently. Clinical symptoms in both patients showed improvement after initiation of thiamine administration, although some residual deficit remained. Conclusion: Thiamine deficiency must be actively considered as a possible cause of polyneuropathy, and variability in its clinical features should be taken into consideration.

Original languageEnglish
Pages (from-to)776-780
Number of pages5
JournalNutrition
Volume24
Issue number7-8
DOIs
Publication statusPublished - 01-07-2008

Fingerprint

Beriberi
Thiamine Deficiency
Polyneuropathies
Wernicke Encephalopathy
Intestinal Pseudo-Obstruction
Lactic Acidosis
Urinary Retention
Thiamine
Muscle Weakness
Gastrectomy
Lower Extremity
Heart Failure
Alcohols
Neoplasms

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

Koike, H., Ito, S., Morozumi, S., Kawagashira, Y., Iijima, M., Hattori, N., ... Sobue, G. (2008). Rapidly developing weakness mimicking Guillain-Barré syndrome in beriberi neuropathy: Two case reports. Nutrition, 24(7-8), 776-780. https://doi.org/10.1016/j.nut.2008.02.022
Koike, Haruki ; Ito, Shinji ; Morozumi, Saori ; Kawagashira, Yuichi ; Iijima, Masahiro ; Hattori, Naoki ; Tanaka, Fumiaki ; Sobue, Gen. / Rapidly developing weakness mimicking Guillain-Barré syndrome in beriberi neuropathy : Two case reports. In: Nutrition. 2008 ; Vol. 24, No. 7-8. pp. 776-780.
@article{0a4e334901fe46839ab1737768a91d22,
title = "Rapidly developing weakness mimicking Guillain-Barr{\'e} syndrome in beriberi neuropathy: Two case reports",
abstract = "Objective: We examined the diagnostic difficulty in thiamine deficiency. Methods: We report on two patients with polyneuropathy associated with thiamine deficiency (i.e., beriberi neuropathy) that presented with acute motor symptoms mimicking Guillain-Barr{\'e} syndrome. Results: The cause of the thiamine deficiency was associated with gastrectomy to treat cancer in a 46-y-old man and with dietary imbalance in a 33-y-old man. The thiamine deficiency was not related to alcohol intake in either patient. In both patients, the upper and lower extremities showed a rapidly progressive weakness over the course of 1 mo. Muscle weakness in the first patient progressed even after admission to the hospital, and urinary retention, Wernicke's encephalopathy, lactic acidosis, paralytic ileus, and heart failure appeared subsequently. Clinical symptoms in both patients showed improvement after initiation of thiamine administration, although some residual deficit remained. Conclusion: Thiamine deficiency must be actively considered as a possible cause of polyneuropathy, and variability in its clinical features should be taken into consideration.",
author = "Haruki Koike and Shinji Ito and Saori Morozumi and Yuichi Kawagashira and Masahiro Iijima and Naoki Hattori and Fumiaki Tanaka and Gen Sobue",
year = "2008",
month = "7",
day = "1",
doi = "10.1016/j.nut.2008.02.022",
language = "English",
volume = "24",
pages = "776--780",
journal = "Nutrition",
issn = "0899-9007",
publisher = "Elsevier Inc.",
number = "7-8",

}

Koike, H, Ito, S, Morozumi, S, Kawagashira, Y, Iijima, M, Hattori, N, Tanaka, F & Sobue, G 2008, 'Rapidly developing weakness mimicking Guillain-Barré syndrome in beriberi neuropathy: Two case reports', Nutrition, vol. 24, no. 7-8, pp. 776-780. https://doi.org/10.1016/j.nut.2008.02.022

Rapidly developing weakness mimicking Guillain-Barré syndrome in beriberi neuropathy : Two case reports. / Koike, Haruki; Ito, Shinji; Morozumi, Saori; Kawagashira, Yuichi; Iijima, Masahiro; Hattori, Naoki; Tanaka, Fumiaki; Sobue, Gen.

In: Nutrition, Vol. 24, No. 7-8, 01.07.2008, p. 776-780.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Rapidly developing weakness mimicking Guillain-Barré syndrome in beriberi neuropathy

T2 - Two case reports

AU - Koike, Haruki

AU - Ito, Shinji

AU - Morozumi, Saori

AU - Kawagashira, Yuichi

AU - Iijima, Masahiro

AU - Hattori, Naoki

AU - Tanaka, Fumiaki

AU - Sobue, Gen

PY - 2008/7/1

Y1 - 2008/7/1

N2 - Objective: We examined the diagnostic difficulty in thiamine deficiency. Methods: We report on two patients with polyneuropathy associated with thiamine deficiency (i.e., beriberi neuropathy) that presented with acute motor symptoms mimicking Guillain-Barré syndrome. Results: The cause of the thiamine deficiency was associated with gastrectomy to treat cancer in a 46-y-old man and with dietary imbalance in a 33-y-old man. The thiamine deficiency was not related to alcohol intake in either patient. In both patients, the upper and lower extremities showed a rapidly progressive weakness over the course of 1 mo. Muscle weakness in the first patient progressed even after admission to the hospital, and urinary retention, Wernicke's encephalopathy, lactic acidosis, paralytic ileus, and heart failure appeared subsequently. Clinical symptoms in both patients showed improvement after initiation of thiamine administration, although some residual deficit remained. Conclusion: Thiamine deficiency must be actively considered as a possible cause of polyneuropathy, and variability in its clinical features should be taken into consideration.

AB - Objective: We examined the diagnostic difficulty in thiamine deficiency. Methods: We report on two patients with polyneuropathy associated with thiamine deficiency (i.e., beriberi neuropathy) that presented with acute motor symptoms mimicking Guillain-Barré syndrome. Results: The cause of the thiamine deficiency was associated with gastrectomy to treat cancer in a 46-y-old man and with dietary imbalance in a 33-y-old man. The thiamine deficiency was not related to alcohol intake in either patient. In both patients, the upper and lower extremities showed a rapidly progressive weakness over the course of 1 mo. Muscle weakness in the first patient progressed even after admission to the hospital, and urinary retention, Wernicke's encephalopathy, lactic acidosis, paralytic ileus, and heart failure appeared subsequently. Clinical symptoms in both patients showed improvement after initiation of thiamine administration, although some residual deficit remained. Conclusion: Thiamine deficiency must be actively considered as a possible cause of polyneuropathy, and variability in its clinical features should be taken into consideration.

UR - http://www.scopus.com/inward/record.url?scp=44749086502&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=44749086502&partnerID=8YFLogxK

U2 - 10.1016/j.nut.2008.02.022

DO - 10.1016/j.nut.2008.02.022

M3 - Article

C2 - 18440777

AN - SCOPUS:44749086502

VL - 24

SP - 776

EP - 780

JO - Nutrition

JF - Nutrition

SN - 0899-9007

IS - 7-8

ER -