Rate of the “burnt-out diabetes” phenomenon in patients on peritoneal dialysis

Masanori Abe, Takayuki Hamano, Junichi Hoshino, Atsushi Wada, Shigeru Nakai, Ikuto Masakane

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Aims: In some diabetes patients on dialysis, glycemic control improves spontaneously, leading to normal HbA1c levels; this phenomenon is known as “burnt-out diabetes.” Glycated albumin (GA) might be a better indicator of glycemic control than HbA1c in hemodialysis patients, but it has not been assessed in peritoneal dialysis (PD) patients. Methods: This study involved diabetes patients on PD, with HbA1c level and antidiabetes therapy records. First, the “burnt-out diabetes” phenomenon was investigated in patients with HbA1c measurements alone (HbA1c cohort). Then, it was investigated in patients with both HbA1c and GA measurements (GA cohort). Results: A total of 1296 patients were included in the HbA1c cohort. When “burnt-out diabetes” was defined as HbA1c < 6.0% without treatment, it was noted in 269 patients (20.8%). A total of 413 patients were subsequently included in the GA cohort. “Burnt-out diabetes,” using the same definition, was found in 73 patients (17.7%). However, when defined as HbA1c < 6.0% and GA < 16.0% without treatment, “burnt-out diabetes” was found in 45 patients (10.9%). Conclusions: Although the “burnt-out diabetes” phenomenon was present in 17.7% of patients with diabetes on PD based on HbA1c, the rate was significantly decreased to 10.9% when taking GA into account.

Original languageEnglish
Pages (from-to)254-262
Number of pages9
JournalDiabetes Research and Clinical Practice
Volume143
DOIs
Publication statusPublished - 09-2018

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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