Reactivation of human herpesvirus 6 and 7 in pregnant women

Masahiro Ohashi, Tetsushi Yoshikawa, Masaru Ihira, Kyoko Suzuki, Sadao Suga, Shin Tada, Yasuhiro Udagawa, Hisataka Sakui, Keiji Iida, Yumiko Saito, Yukihiro Nisiyama, Yoshizo Asano

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

To elucidate the roles of human herpesvirus (HHV)-6 and -7 in pregnant women, peripheral blood samples and genital tract secretions were collected serially from pregnant women, and both serological testing and polymerase chain reaction (PCR) were carried out to detect viral DNA in the secretions. HHV-6 or HHV-7 Immunoglobulin(Ig)M antibodies were not detected in 432 plasma samples collected from pregnant women and cord blood, but IgG antibodies against both viruses were detected in all plasma samples. Significant increases in HHV-6 and HHV-7 IgG antibodies were observed in two (1.6%) and three (2.4%) pregnant women respectively of a total of 123 cases. HHV-6 DNA was detected in the genital tract in three (3.7%) of 82 pregnant women at the first trimester, and in 10 (12.2%) of the same women in the third trimester. The detection rate in the third trimester was significantly higher than that in the first trimester (P=0.043). Although HHV-7 DNA was detected in the genital tract of two (2.7%) and seven (9.6%) pregnant women of a total of 73 during the first and third trimesters respectively, there was no statistical difference in the detection rate of the viral DNA between the trimesters. Because a significant increase in HHV-6 IgG antibodies was detected in only two pregnant women, it was not possible to carry out statistical analysis to determine the relationship between HHV-6 infection and associated clinical features. Although there was a significant increase in HHV-7 antibody titers in three pregnant women, a positive correlation between the virus infection and the clinical features was not demonstrated. There was no statistical association between virus shedding in the genital tract and the clinical features examined in this study.

Original languageEnglish
Pages (from-to)354-358
Number of pages5
JournalJournal of Medical Virology
Volume67
Issue number3
DOIs
Publication statusPublished - 08-06-2002

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Human Herpesvirus 7
Human Herpesvirus 6
Pregnant Women
Third Pregnancy Trimester
First Pregnancy Trimester
Antibodies
Immunoglobulin G
Viral DNA
Virus Shedding
Herpesviridae Infections
DNA
Virus Diseases
Fetal Blood
Immunoglobulin M
Viruses
Polymerase Chain Reaction

All Science Journal Classification (ASJC) codes

  • Virology
  • Infectious Diseases

Cite this

Ohashi, Masahiro ; Yoshikawa, Tetsushi ; Ihira, Masaru ; Suzuki, Kyoko ; Suga, Sadao ; Tada, Shin ; Udagawa, Yasuhiro ; Sakui, Hisataka ; Iida, Keiji ; Saito, Yumiko ; Nisiyama, Yukihiro ; Asano, Yoshizo. / Reactivation of human herpesvirus 6 and 7 in pregnant women. In: Journal of Medical Virology. 2002 ; Vol. 67, No. 3. pp. 354-358.
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abstract = "To elucidate the roles of human herpesvirus (HHV)-6 and -7 in pregnant women, peripheral blood samples and genital tract secretions were collected serially from pregnant women, and both serological testing and polymerase chain reaction (PCR) were carried out to detect viral DNA in the secretions. HHV-6 or HHV-7 Immunoglobulin(Ig)M antibodies were not detected in 432 plasma samples collected from pregnant women and cord blood, but IgG antibodies against both viruses were detected in all plasma samples. Significant increases in HHV-6 and HHV-7 IgG antibodies were observed in two (1.6{\%}) and three (2.4{\%}) pregnant women respectively of a total of 123 cases. HHV-6 DNA was detected in the genital tract in three (3.7{\%}) of 82 pregnant women at the first trimester, and in 10 (12.2{\%}) of the same women in the third trimester. The detection rate in the third trimester was significantly higher than that in the first trimester (P=0.043). Although HHV-7 DNA was detected in the genital tract of two (2.7{\%}) and seven (9.6{\%}) pregnant women of a total of 73 during the first and third trimesters respectively, there was no statistical difference in the detection rate of the viral DNA between the trimesters. Because a significant increase in HHV-6 IgG antibodies was detected in only two pregnant women, it was not possible to carry out statistical analysis to determine the relationship between HHV-6 infection and associated clinical features. Although there was a significant increase in HHV-7 antibody titers in three pregnant women, a positive correlation between the virus infection and the clinical features was not demonstrated. There was no statistical association between virus shedding in the genital tract and the clinical features examined in this study.",
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Ohashi, M, Yoshikawa, T, Ihira, M, Suzuki, K, Suga, S, Tada, S, Udagawa, Y, Sakui, H, Iida, K, Saito, Y, Nisiyama, Y & Asano, Y 2002, 'Reactivation of human herpesvirus 6 and 7 in pregnant women', Journal of Medical Virology, vol. 67, no. 3, pp. 354-358. https://doi.org/10.1002/jmv.10083

Reactivation of human herpesvirus 6 and 7 in pregnant women. / Ohashi, Masahiro; Yoshikawa, Tetsushi; Ihira, Masaru; Suzuki, Kyoko; Suga, Sadao; Tada, Shin; Udagawa, Yasuhiro; Sakui, Hisataka; Iida, Keiji; Saito, Yumiko; Nisiyama, Yukihiro; Asano, Yoshizo.

In: Journal of Medical Virology, Vol. 67, No. 3, 08.06.2002, p. 354-358.

Research output: Contribution to journalArticle

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T1 - Reactivation of human herpesvirus 6 and 7 in pregnant women

AU - Ohashi, Masahiro

AU - Yoshikawa, Tetsushi

AU - Ihira, Masaru

AU - Suzuki, Kyoko

AU - Suga, Sadao

AU - Tada, Shin

AU - Udagawa, Yasuhiro

AU - Sakui, Hisataka

AU - Iida, Keiji

AU - Saito, Yumiko

AU - Nisiyama, Yukihiro

AU - Asano, Yoshizo

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