Receptor protein tyrosine kinase DDR is up-regulated by p53 protein

Shirou Sakuma; Hideyuki Saya; Mitsuhiro Tada; Mitsuyoshi Nakao; Toshiyoshi Fujiwara; Jack A. Roth; Yutaka Sawamura; Yumiko Shinohe; Abe Hiroshi

doi:10.1016/S0014-5793(96)01234-3

Receptor protein tyrosine kinase DDR is up-regulated by p53 protein

Shirou Sakuma, Hideyuki Saya, Mitsuhiro Tada, Mitsuyoshi Nakao, Toshiyoshi Fujiwara, Jack A. Roth, Yutaka Sawamura, Yumiko Shinohe, Abe Hiroshi

Cancer Center

Research output: Contribution to journal › Article

27 Citations (Scopus)

Abstract

We have previously reported on radiation-induction of ptk-3 in rat astr ocyte culture [Sakuma et al. (1995) Radiat. Res. 143, 1-7]. Ptk-3 was considered to be a rat version of human DDR (discoidin domain receptor). We cloned and analyzed genomic DNA of the DDR and its promoter region. We discovered that the promoter region contained a consensus sequence of the p53 tumor suppressor binding site. Adenovirus-mediated p53 transfection induced a high level of DDR mRNA in SAOS2 human osteosarcoma cells. These results indicate that DDR is up-regulated by the p53 protein.

Original language	English
Pages (from-to)	165-169
Number of pages	5
Journal	FEBS Letters
Volume	398
Issue number	2-3
DOIs	https://doi.org/10.1016/S0014-5793(96)01234-3
Publication status	Published - 02-12-1996

All Science Journal Classification (ASJC) codes

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

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Sakuma, S., Saya, H., Tada, M., Nakao, M., Fujiwara, T., Roth, J. A., Sawamura, Y., Shinohe, Y., & Hiroshi, A. (1996). Receptor protein tyrosine kinase DDR is up-regulated by p53 protein. FEBS Letters, 398(2-3), 165-169. https://doi.org/10.1016/S0014-5793(96)01234-3

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AU - Fujiwara, Toshiyoshi

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AU - Hiroshi, Abe

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