TY - JOUR
T1 - Receptor protein tyrosine kinase DDR is up-regulated by p53 protein
AU - Sakuma, Shirou
AU - Saya, Hideyuki
AU - Tada, Mitsuhiro
AU - Nakao, Mitsuyoshi
AU - Fujiwara, Toshiyoshi
AU - Roth, Jack A.
AU - Sawamura, Yutaka
AU - Shinohe, Yumiko
AU - Hiroshi, Abe
N1 - Copyright:
Copyright 2007 Elsevier B.V., All rights reserved.
PY - 1996/12/2
Y1 - 1996/12/2
N2 - We have previously reported on radiation-induction of ptk-3 in rat astr ocyte culture [Sakuma et al. (1995) Radiat. Res. 143, 1-7]. Ptk-3 was considered to be a rat version of human DDR (discoidin domain receptor). We cloned and analyzed genomic DNA of the DDR and its promoter region. We discovered that the promoter region contained a consensus sequence of the p53 tumor suppressor binding site. Adenovirus-mediated p53 transfection induced a high level of DDR mRNA in SAOS2 human osteosarcoma cells. These results indicate that DDR is up-regulated by the p53 protein.
AB - We have previously reported on radiation-induction of ptk-3 in rat astr ocyte culture [Sakuma et al. (1995) Radiat. Res. 143, 1-7]. Ptk-3 was considered to be a rat version of human DDR (discoidin domain receptor). We cloned and analyzed genomic DNA of the DDR and its promoter region. We discovered that the promoter region contained a consensus sequence of the p53 tumor suppressor binding site. Adenovirus-mediated p53 transfection induced a high level of DDR mRNA in SAOS2 human osteosarcoma cells. These results indicate that DDR is up-regulated by the p53 protein.
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U2 - 10.1016/S0014-5793(96)01234-3
DO - 10.1016/S0014-5793(96)01234-3
M3 - Article
C2 - 8977099
AN - SCOPUS:0030566840
VL - 398
SP - 165
EP - 169
JO - FEBS Letters
JF - FEBS Letters
SN - 0014-5793
IS - 2-3
ER -