Receptor signaling integration by TRP channelsomes

Yasuo Mori, Taketoshi Kajimoto, Akito Nakao, Nobuaki Takahashi, Shigeki Kiyonaka

Research output: Chapter in Book/Report/Conference proceedingConference contribution

9 Citations (Scopus)


Homologues of transient receptor potential (TRP) genes encode a variety of cation channels, most of which conduct Ca 2+ across the plasma membrane. TRP proteins interact with a variety of proteins and other biologically important factors, such as second messengers, and thereby form "channelsomes", most of which function as Ca 2+ signalsomes. Activation mechanisms and final outputs are exquisitely incorporated in the signaling system of TRP channelsomes. In this study, we discuss the channelsomes of TRPC3, TRPC5, and TRPM2, which show unique molecular interactions and modulations of activation. Comparative studies of these specific TRP channelsomes should aid the determination of general rules that govern the formation and regulation of channelsomes and signalsomes.

Original languageEnglish
Title of host publicationTransient Receptor Potential Channels
EditorsShahidul Islam, Shahidul Islam
Number of pages17
Publication statusPublished - 15-12-2011

Publication series

NameAdvances in Experimental Medicine and Biology
ISSN (Print)0065-2598

All Science Journal Classification (ASJC) codes

  • General Biochemistry,Genetics and Molecular Biology


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