Receptor signaling integration by TRP channelsomes

Yasuo Mori; Taketoshi Kajimoto; Akito Nakao; Nobuaki Takahashi; Shigeki Kiyonaka

doi:10.1007/978-94-007-0265-3_21

Receptor signaling integration by TRP channelsomes

Yasuo Mori, Taketoshi Kajimoto, Akito Nakao, Nobuaki Takahashi, Shigeki Kiyonaka

Division of Systems Medical Science

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

8 Citations (Scopus)

Abstract

Homologues of transient receptor potential (TRP) genes encode a variety of cation channels, most of which conduct Ca ²⁺ across the plasma membrane. TRP proteins interact with a variety of proteins and other biologically important factors, such as second messengers, and thereby form "channelsomes", most of which function as Ca ²⁺ signalsomes. Activation mechanisms and final outputs are exquisitely incorporated in the signaling system of TRP channelsomes. In this study, we discuss the channelsomes of TRPC3, TRPC5, and TRPM2, which show unique molecular interactions and modulations of activation. Comparative studies of these specific TRP channelsomes should aid the determination of general rules that govern the formation and regulation of channelsomes and signalsomes.

Original language	English
Title of host publication	Transient Receptor Potential Channels
Editors	Shahidul Islam, Shahidul Islam
Pages	373-389
Number of pages	17
DOIs	https://doi.org/10.1007/978-94-007-0265-3_21
Publication status	Published - 15-12-2011

Publication series

Name	Advances in Experimental Medicine and Biology
Volume	704
ISSN (Print)	0065-2598

All Science Journal Classification (ASJC) codes

Biochemistry, Genetics and Molecular Biology(all)

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title = "Receptor signaling integration by TRP channelsomes",

abstract = "Homologues of transient receptor potential (TRP) genes encode a variety of cation channels, most of which conduct Ca 2+ across the plasma membrane. TRP proteins interact with a variety of proteins and other biologically important factors, such as second messengers, and thereby form {"}channelsomes{"}, most of which function as Ca 2+ signalsomes. Activation mechanisms and final outputs are exquisitely incorporated in the signaling system of TRP channelsomes. In this study, we discuss the channelsomes of TRPC3, TRPC5, and TRPM2, which show unique molecular interactions and modulations of activation. Comparative studies of these specific TRP channelsomes should aid the determination of general rules that govern the formation and regulation of channelsomes and signalsomes.",

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Receptor signaling integration by TRP channelsomes. / Mori, Yasuo; Kajimoto, Taketoshi; Nakao, Akito; Takahashi, Nobuaki; Kiyonaka, Shigeki.

Transient Receptor Potential Channels. ed. / Shahidul Islam; Shahidul Islam. 2011. p. 373-389 (Advances in Experimental Medicine and Biology; Vol. 704).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

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