TY - GEN
T1 - Receptor signaling integration by TRP channelsomes
AU - Mori, Yasuo
AU - Kajimoto, Taketoshi
AU - Nakao, Akito
AU - Takahashi, Nobuaki
AU - Kiyonaka, Shigeki
PY - 2011/12/15
Y1 - 2011/12/15
N2 - Homologues of transient receptor potential (TRP) genes encode a variety of cation channels, most of which conduct Ca 2+ across the plasma membrane. TRP proteins interact with a variety of proteins and other biologically important factors, such as second messengers, and thereby form "channelsomes", most of which function as Ca 2+ signalsomes. Activation mechanisms and final outputs are exquisitely incorporated in the signaling system of TRP channelsomes. In this study, we discuss the channelsomes of TRPC3, TRPC5, and TRPM2, which show unique molecular interactions and modulations of activation. Comparative studies of these specific TRP channelsomes should aid the determination of general rules that govern the formation and regulation of channelsomes and signalsomes.
AB - Homologues of transient receptor potential (TRP) genes encode a variety of cation channels, most of which conduct Ca 2+ across the plasma membrane. TRP proteins interact with a variety of proteins and other biologically important factors, such as second messengers, and thereby form "channelsomes", most of which function as Ca 2+ signalsomes. Activation mechanisms and final outputs are exquisitely incorporated in the signaling system of TRP channelsomes. In this study, we discuss the channelsomes of TRPC3, TRPC5, and TRPM2, which show unique molecular interactions and modulations of activation. Comparative studies of these specific TRP channelsomes should aid the determination of general rules that govern the formation and regulation of channelsomes and signalsomes.
UR - http://www.scopus.com/inward/record.url?scp=79959777289&partnerID=8YFLogxK
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U2 - 10.1007/978-94-007-0265-3_21
DO - 10.1007/978-94-007-0265-3_21
M3 - Conference contribution
C2 - 21290307
AN - SCOPUS:79959777289
SN - 9789400702646
T3 - Advances in Experimental Medicine and Biology
SP - 373
EP - 389
BT - Transient Receptor Potential Channels
A2 - Islam, Shahidul
A2 - Islam, Shahidul
ER -