Receptor signaling integration by TRP channelsomes

Yasuo Mori, Taketoshi Kajimoto, Akito Nakao, Nobuaki Takahashi, Shigeki Kiyonaka

Research output: Chapter in Book/Report/Conference proceedingConference contribution

8 Citations (Scopus)

Abstract

Homologues of transient receptor potential (TRP) genes encode a variety of cation channels, most of which conduct Ca 2+ across the plasma membrane. TRP proteins interact with a variety of proteins and other biologically important factors, such as second messengers, and thereby form "channelsomes", most of which function as Ca 2+ signalsomes. Activation mechanisms and final outputs are exquisitely incorporated in the signaling system of TRP channelsomes. In this study, we discuss the channelsomes of TRPC3, TRPC5, and TRPM2, which show unique molecular interactions and modulations of activation. Comparative studies of these specific TRP channelsomes should aid the determination of general rules that govern the formation and regulation of channelsomes and signalsomes.

Original languageEnglish
Title of host publicationTransient Receptor Potential Channels
Pages373-389
Number of pages17
DOIs
Publication statusPublished - 15-12-2011
Externally publishedYes

Publication series

NameAdvances in Experimental Medicine and Biology
Volume704
ISSN (Print)0065-2598

Fingerprint

Second Messenger Systems
Cations
Proteins
Chemical activation
Cell Membrane
Molecular interactions
Cell membranes
Genes
Modulation

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Mori, Y., Kajimoto, T., Nakao, A., Takahashi, N., & Kiyonaka, S. (2011). Receptor signaling integration by TRP channelsomes. In Transient Receptor Potential Channels (pp. 373-389). (Advances in Experimental Medicine and Biology; Vol. 704). https://doi.org/10.1007/978-94-007-0265-3_21
Mori, Yasuo ; Kajimoto, Taketoshi ; Nakao, Akito ; Takahashi, Nobuaki ; Kiyonaka, Shigeki. / Receptor signaling integration by TRP channelsomes. Transient Receptor Potential Channels. 2011. pp. 373-389 (Advances in Experimental Medicine and Biology).
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Mori, Y, Kajimoto, T, Nakao, A, Takahashi, N & Kiyonaka, S 2011, Receptor signaling integration by TRP channelsomes. in Transient Receptor Potential Channels. Advances in Experimental Medicine and Biology, vol. 704, pp. 373-389. https://doi.org/10.1007/978-94-007-0265-3_21

Receptor signaling integration by TRP channelsomes. / Mori, Yasuo; Kajimoto, Taketoshi; Nakao, Akito; Takahashi, Nobuaki; Kiyonaka, Shigeki.

Transient Receptor Potential Channels. 2011. p. 373-389 (Advances in Experimental Medicine and Biology; Vol. 704).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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Mori Y, Kajimoto T, Nakao A, Takahashi N, Kiyonaka S. Receptor signaling integration by TRP channelsomes. In Transient Receptor Potential Channels. 2011. p. 373-389. (Advances in Experimental Medicine and Biology). https://doi.org/10.1007/978-94-007-0265-3_21