Recombinant human superoxide dismutase can attenuate ischemic neuronal damage in gerbils

Masafumi Tagaya, Masayasu Matsumoto, Kazuo Kitagawa, Michio Niinobe, Toshiho Ohtsuki, Ryuji Hata, Satoshi Ogawa, Nobuo Handa, Katsuhiko Mikoshiba, Takenobu Kamada

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32 Citations (Scopus)

Abstract

The effects of recombinant human superoxide dismutase (r-hSOD) on ischemic neuronal injury were examined. Cerebral ischemia was produced in Mongolian gerbils by occluding bilateral common carotid arteries for 5 min. Preischemic treatment with r-hSOD clearly reduced hippocampal neuronal damages while postischemic treatment did not. This result suggests that oxygen free radicals play an important role in selective vulnerability to ischemia and r-hSOD has a potential clinical usefulness against cerebral ischemia.

Original languageEnglish
Pages (from-to)253-259
Number of pages7
JournalLife Sciences
Volume51
Issue number4
DOIs
Publication statusPublished - 1992
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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  • Cite this

    Tagaya, M., Matsumoto, M., Kitagawa, K., Niinobe, M., Ohtsuki, T., Hata, R., Ogawa, S., Handa, N., Mikoshiba, K., & Kamada, T. (1992). Recombinant human superoxide dismutase can attenuate ischemic neuronal damage in gerbils. Life Sciences, 51(4), 253-259. https://doi.org/10.1016/0024-3205(92)90083-2