Recombinant human superoxide dismutase can attenuate ischemic neuronal damage in gerbils

Masafumi Tagaya; Masayasu Matsumoto; Kazuo Kitagawa; Michio Niinobe; Toshiho Ohtsuki; Ryuji Hata; Satoshi Ogawa; Nobuo Handa; Katsuhiko Mikoshiba; Takenobu Kamada

doi:10.1016/0024-3205(92)90083-2

Recombinant human superoxide dismutase can attenuate ischemic neuronal damage in gerbils

Masafumi Tagaya, Masayasu Matsumoto, Kazuo Kitagawa, Michio Niinobe, Toshiho Ohtsuki, Ryuji Hata, Satoshi Ogawa, Nobuo Handa, Katsuhiko Mikoshiba, Takenobu Kamada

Research output: Contribution to journal › Article › peer-review

34 Citations (Scopus)

Abstract

The effects of recombinant human superoxide dismutase (r-hSOD) on ischemic neuronal injury were examined. Cerebral ischemia was produced in Mongolian gerbils by occluding bilateral common carotid arteries for 5 min. Preischemic treatment with r-hSOD clearly reduced hippocampal neuronal damages while postischemic treatment did not. This result suggests that oxygen free radicals play an important role in selective vulnerability to ischemia and r-hSOD has a potential clinical usefulness against cerebral ischemia.

Original language	English
Pages (from-to)	253-259
Number of pages	7
Journal	Life Sciences
Volume	51
Issue number	4
DOIs	https://doi.org/10.1016/0024-3205(92)90083-2
Publication status	Published - 1992
Externally published	Yes

All Science Journal Classification (ASJC) codes

General Pharmacology, Toxicology and Pharmaceutics
General Biochemistry,Genetics and Molecular Biology

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10.1016/0024-3205(92)90083-2

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title = "Recombinant human superoxide dismutase can attenuate ischemic neuronal damage in gerbils",

abstract = "The effects of recombinant human superoxide dismutase (r-hSOD) on ischemic neuronal injury were examined. Cerebral ischemia was produced in Mongolian gerbils by occluding bilateral common carotid arteries for 5 min. Preischemic treatment with r-hSOD clearly reduced hippocampal neuronal damages while postischemic treatment did not. This result suggests that oxygen free radicals play an important role in selective vulnerability to ischemia and r-hSOD has a potential clinical usefulness against cerebral ischemia.",

author = "Masafumi Tagaya and Masayasu Matsumoto and Kazuo Kitagawa and Michio Niinobe and Toshiho Ohtsuki and Ryuji Hata and Satoshi Ogawa and Nobuo Handa and Katsuhiko Mikoshiba and Takenobu Kamada",

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T1 - Recombinant human superoxide dismutase can attenuate ischemic neuronal damage in gerbils

AU - Tagaya, Masafumi

AU - Matsumoto, Masayasu

AU - Kitagawa, Kazuo

AU - Niinobe, Michio

AU - Ohtsuki, Toshiho

AU - Hata, Ryuji

AU - Ogawa, Satoshi

AU - Handa, Nobuo

AU - Mikoshiba, Katsuhiko

AU - Kamada, Takenobu

PY - 1992

Y1 - 1992

N2 - The effects of recombinant human superoxide dismutase (r-hSOD) on ischemic neuronal injury were examined. Cerebral ischemia was produced in Mongolian gerbils by occluding bilateral common carotid arteries for 5 min. Preischemic treatment with r-hSOD clearly reduced hippocampal neuronal damages while postischemic treatment did not. This result suggests that oxygen free radicals play an important role in selective vulnerability to ischemia and r-hSOD has a potential clinical usefulness against cerebral ischemia.

AB - The effects of recombinant human superoxide dismutase (r-hSOD) on ischemic neuronal injury were examined. Cerebral ischemia was produced in Mongolian gerbils by occluding bilateral common carotid arteries for 5 min. Preischemic treatment with r-hSOD clearly reduced hippocampal neuronal damages while postischemic treatment did not. This result suggests that oxygen free radicals play an important role in selective vulnerability to ischemia and r-hSOD has a potential clinical usefulness against cerebral ischemia.

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SN - 0024-3205

VL - 51

SP - 253

EP - 259

JO - Life Sciences

JF - Life Sciences

IS - 4

ER -

Recombinant human superoxide dismutase can attenuate ischemic neuronal damage in gerbils

Abstract

All Science Journal Classification (ASJC) codes

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