Recombinant human superoxide dismutase can attenuate ischemic neuronal damage in gerbils

Masafumi Tagaya; Masayasu Matsumoto; Kazuo Kitagawa; Michio Niinobe; Toshiho Ohtsuki; Ryuji Hata; Satoshi Ogawa; Nobuo Handa; Katsuhiko Mikoshiba; Takenobu Kamada

doi:10.1016/0024-3205(92)90083-2

Recombinant human superoxide dismutase can attenuate ischemic neuronal damage in gerbils

Masafumi Tagaya
, Masayasu Matsumoto
, Kazuo Kitagawa
, Michio Niinobe
, Toshiho Ohtsuki
, Ryuji Hata
, Satoshi Ogawa
, Nobuo Handa
, Katsuhiko Mikoshiba
, Takenobu Kamada

Research output: Contribution to journal › Article › peer-review

34 Citations (Scopus)

Abstract

The effects of recombinant human superoxide dismutase (r-hSOD) on ischemic neuronal injury were examined. Cerebral ischemia was produced in Mongolian gerbils by occluding bilateral common carotid arteries for 5 min. Preischemic treatment with r-hSOD clearly reduced hippocampal neuronal damages while postischemic treatment did not. This result suggests that oxygen free radicals play an important role in selective vulnerability to ischemia and r-hSOD has a potential clinical usefulness against cerebral ischemia.

Original language	English
Pages (from-to)	253-259
Number of pages	7
Journal	Life Sciences
Volume	51
Issue number	4
DOIs	https://doi.org/10.1016/0024-3205(92)90083-2
Publication status	Published - 1992
Externally published	Yes

All Science Journal Classification (ASJC) codes

General Pharmacology, Toxicology and Pharmaceutics
General Biochemistry,Genetics and Molecular Biology

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10.1016/0024-3205(92)90083-2

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title = "Recombinant human superoxide dismutase can attenuate ischemic neuronal damage in gerbils",

abstract = "The effects of recombinant human superoxide dismutase (r-hSOD) on ischemic neuronal injury were examined. Cerebral ischemia was produced in Mongolian gerbils by occluding bilateral common carotid arteries for 5 min. Preischemic treatment with r-hSOD clearly reduced hippocampal neuronal damages while postischemic treatment did not. This result suggests that oxygen free radicals play an important role in selective vulnerability to ischemia and r-hSOD has a potential clinical usefulness against cerebral ischemia.",

author = "Masafumi Tagaya and Masayasu Matsumoto and Kazuo Kitagawa and Michio Niinobe and Toshiho Ohtsuki and Ryuji Hata and Satoshi Ogawa and Nobuo Handa and Katsuhiko Mikoshiba and Takenobu Kamada",

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doi = "10.1016/0024-3205(92)90083-2",

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T1 - Recombinant human superoxide dismutase can attenuate ischemic neuronal damage in gerbils

AU - Tagaya, Masafumi

AU - Matsumoto, Masayasu

AU - Kitagawa, Kazuo

AU - Niinobe, Michio

AU - Ohtsuki, Toshiho

AU - Hata, Ryuji

AU - Ogawa, Satoshi

AU - Handa, Nobuo

AU - Mikoshiba, Katsuhiko

AU - Kamada, Takenobu

PY - 1992

Y1 - 1992

N2 - The effects of recombinant human superoxide dismutase (r-hSOD) on ischemic neuronal injury were examined. Cerebral ischemia was produced in Mongolian gerbils by occluding bilateral common carotid arteries for 5 min. Preischemic treatment with r-hSOD clearly reduced hippocampal neuronal damages while postischemic treatment did not. This result suggests that oxygen free radicals play an important role in selective vulnerability to ischemia and r-hSOD has a potential clinical usefulness against cerebral ischemia.

AB - The effects of recombinant human superoxide dismutase (r-hSOD) on ischemic neuronal injury were examined. Cerebral ischemia was produced in Mongolian gerbils by occluding bilateral common carotid arteries for 5 min. Preischemic treatment with r-hSOD clearly reduced hippocampal neuronal damages while postischemic treatment did not. This result suggests that oxygen free radicals play an important role in selective vulnerability to ischemia and r-hSOD has a potential clinical usefulness against cerebral ischemia.

UR - https://www.scopus.com/pages/publications/0026635946

UR - https://www.scopus.com/pages/publications/0026635946#tab=citedBy

U2 - 10.1016/0024-3205(92)90083-2

DO - 10.1016/0024-3205(92)90083-2

M3 - Article

C2 - 1625516

AN - SCOPUS:0026635946

SN - 0024-3205

VL - 51

SP - 253

EP - 259

JO - Life Sciences

JF - Life Sciences

IS - 4

ER -

Recombinant human superoxide dismutase can attenuate ischemic neuronal damage in gerbils

Abstract

All Science Journal Classification (ASJC) codes

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