Recurrent autoimmune hemolytic anemia induced by XELOX chemotherapy for colon cancer

Takeshi Ogura, Masahiro Tajika, Yasumasa Niwa, Hiroki Kawai, Shinya Kondo, Akira Sawaki, Nobumasa Mizuno, Kazuo Hara, Susumu Hijioka, Masamichi Nakamura, Kazuhide Higuchi, Hidemi Goto, Kenji Yamao

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


We describe a 54-year old woman with oxaliplatin-induced autoimmune hemolytic anemia and review the clinical features of similar published cases. The present patient had metastatic colon cancer and was admitted to our hospital with a floating sensation and general malaise on day 4 after undergoing the last of 4 cycles of a 7 th round of chemotherapy with XELOX. Laboratory data revealed 4.6g/d/ hemoglobin and 8.77 mg/d/ creatinine. Direct and indirect Coombs tests of a blood sample for blood transfusion were both positive. We diagnosed immune hemolysis with acute renal failure based on the clinical course and blood samples showing haptoglobin <10mg/d/. We treated her with hemodialysis, plasmapheresis and immune suppression with prednisolone, which improved the anemia and renal failure.

Original languageEnglish
Pages (from-to)1712-1719
Number of pages8
JournalJournal of Japanese Society of Gastroenterology
Issue number10
Publication statusPublished - 10-2011

All Science Journal Classification (ASJC) codes

  • Gastroenterology


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