Recurrent autoimmune hemolytic anemia induced by XELOX chemotherapy for colon cancer

Takeshi Ogura; Masahiro Tajika; Yasumasa Niwa; Hiroki Kawai; Shinya Kondo; Akira Sawaki; Nobumasa Mizuno; Kazuo Hara; Susumu Hijioka; Masamichi Nakamura; Kazuhide Higuchi; Hidemi Goto; Kenji Yamao

Recurrent autoimmune hemolytic anemia induced by XELOX chemotherapy for colon cancer

Takeshi Ogura, Masahiro Tajika, Yasumasa Niwa, Hiroki Kawai, Shinya Kondo, Akira Sawaki, Nobumasa Mizuno, Kazuo Hara, Susumu Hijioka, Masamichi Nakamura, Kazuhide Higuchi, Hidemi Goto, Kenji Yamao

Gastroenterology

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

We describe a 54-year old woman with oxaliplatin-induced autoimmune hemolytic anemia and review the clinical features of similar published cases. The present patient had metastatic colon cancer and was admitted to our hospital with a floating sensation and general malaise on day 4 after undergoing the last of 4 cycles of a 7 ^th round of chemotherapy with XELOX. Laboratory data revealed 4.6g/d/ hemoglobin and 8.77 mg/d/ creatinine. Direct and indirect Coombs tests of a blood sample for blood transfusion were both positive. We diagnosed immune hemolysis with acute renal failure based on the clinical course and blood samples showing haptoglobin <10mg/d/. We treated her with hemodialysis, plasmapheresis and immune suppression with prednisolone, which improved the anemia and renal failure.

Original language	English
Pages (from-to)	1712-1719
Number of pages	8
Journal	Journal of Japanese Society of Gastroenterology
Volume	108
Issue number	10
Publication status	Published - 10-2011

All Science Journal Classification (ASJC) codes

Gastroenterology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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title = "Recurrent autoimmune hemolytic anemia induced by XELOX chemotherapy for colon cancer",

abstract = "We describe a 54-year old woman with oxaliplatin-induced autoimmune hemolytic anemia and review the clinical features of similar published cases. The present patient had metastatic colon cancer and was admitted to our hospital with a floating sensation and general malaise on day 4 after undergoing the last of 4 cycles of a 7 th round of chemotherapy with XELOX. Laboratory data revealed 4.6g/d/ hemoglobin and 8.77 mg/d/ creatinine. Direct and indirect Coombs tests of a blood sample for blood transfusion were both positive. We diagnosed immune hemolysis with acute renal failure based on the clinical course and blood samples showing haptoglobin <10mg/d/. We treated her with hemodialysis, plasmapheresis and immune suppression with prednisolone, which improved the anemia and renal failure.",

author = "Takeshi Ogura and Masahiro Tajika and Yasumasa Niwa and Hiroki Kawai and Shinya Kondo and Akira Sawaki and Nobumasa Mizuno and Kazuo Hara and Susumu Hijioka and Masamichi Nakamura and Kazuhide Higuchi and Hidemi Goto and Kenji Yamao",

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language = "English",

volume = "108",

pages = "1712--1719",

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TY - JOUR

T1 - Recurrent autoimmune hemolytic anemia induced by XELOX chemotherapy for colon cancer

AU - Ogura, Takeshi

AU - Tajika, Masahiro

AU - Niwa, Yasumasa

AU - Kawai, Hiroki

AU - Kondo, Shinya

AU - Sawaki, Akira

AU - Mizuno, Nobumasa

AU - Hara, Kazuo

AU - Hijioka, Susumu

AU - Nakamura, Masamichi

AU - Higuchi, Kazuhide

AU - Goto, Hidemi

AU - Yamao, Kenji

PY - 2011/10

Y1 - 2011/10

N2 - We describe a 54-year old woman with oxaliplatin-induced autoimmune hemolytic anemia and review the clinical features of similar published cases. The present patient had metastatic colon cancer and was admitted to our hospital with a floating sensation and general malaise on day 4 after undergoing the last of 4 cycles of a 7 th round of chemotherapy with XELOX. Laboratory data revealed 4.6g/d/ hemoglobin and 8.77 mg/d/ creatinine. Direct and indirect Coombs tests of a blood sample for blood transfusion were both positive. We diagnosed immune hemolysis with acute renal failure based on the clinical course and blood samples showing haptoglobin <10mg/d/. We treated her with hemodialysis, plasmapheresis and immune suppression with prednisolone, which improved the anemia and renal failure.

AB - We describe a 54-year old woman with oxaliplatin-induced autoimmune hemolytic anemia and review the clinical features of similar published cases. The present patient had metastatic colon cancer and was admitted to our hospital with a floating sensation and general malaise on day 4 after undergoing the last of 4 cycles of a 7 th round of chemotherapy with XELOX. Laboratory data revealed 4.6g/d/ hemoglobin and 8.77 mg/d/ creatinine. Direct and indirect Coombs tests of a blood sample for blood transfusion were both positive. We diagnosed immune hemolysis with acute renal failure based on the clinical course and blood samples showing haptoglobin <10mg/d/. We treated her with hemodialysis, plasmapheresis and immune suppression with prednisolone, which improved the anemia and renal failure.

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AN - SCOPUS:80955164967

SN - 0446-6586

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JO - Journal of Japanese Society of Gastroenterology

JF - Journal of Japanese Society of Gastroenterology

IS - 10

ER -

Recurrent autoimmune hemolytic anemia induced by XELOX chemotherapy for colon cancer

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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