Recurrent hepatocellular carcinoma with rapid growth after cardiac surgery

Hideyuki Shimizu, Yoshiaki Katano, Kenichi Nagano, Shoichi Yokozaki, Fukiko Shimizu, Takehito Naito, Kazuhiko Hayashi, Yuko Shimizu, Takashi Honda, Tetsuya Kaneko, Shinji Akita, Isao Nakano, Yoshihide Fukuda

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


A 65-year-old man diagnosed with hepatitis C virus-positive hepatitis and severe valvular heart disease was scheduled to undergo cardiac valve replacement. We then found hepatocellular carcinoma in the liver. Because of his severe cardiac dysfunction, we treated him surgically with radiofrequency ablation for the hepatocellular carcinoma only. We continued medical treatment of the heart disease. He hoped to undergo with cardiac surgery one year later for the cardiac dysfunction. There was no evidence of tumor recurrence. We informed him that cardiac surgery requiring extracorporeal circulation might lead to tumor recurrence. He agreed to cardiac valve replacement, and the surgery was successful. Recurrent hepatocellular carcinoma was found in the liver 1 month after the surgery. Over the next month, the tumor progressed rapidly, showing portal vein thrombi. We believe the use of extracorporeal circulation in particular triggered the rapid growth of the recurrent hepatocellular carcinoma. This is the first report of a recurrent hepatocellular carcinoma associated with hepatitis C virus that progressed extensively after cardiac surgery.

Original languageEnglish
Pages (from-to)1863-1866
Number of pages4
Issue number66
Publication statusPublished - 11-2005
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology


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