Reduced intensity conditioning in allogeneic stem cell transplantation for AML with Down syndrome

Hideki Muramatsu; Hirotoshi Sakaguchi; Takashi Taga; Ken Tabuchi; Souichi Adachi; Masami Inoue; Toshiyuki Kitoh; Aiko Suminoe; Hiromasa Yabe; Eichi Azuma; Yoko Shioda; Atsushi Ogawa; Akitoshi Kinoshita; Hisato Kigasawa; Yuko Osugi; Kazutoshi Koike; Keisei Kawa; Koji Kato; Yoshiko Atsuta; Kazuko Kudo

doi:10.1002/pbc.24883

Reduced intensity conditioning in allogeneic stem cell transplantation for AML with Down syndrome

Hideki Muramatsu
, Hirotoshi Sakaguchi
, Takashi Taga
, Ken Tabuchi
, Souichi Adachi
, Masami Inoue
, Toshiyuki Kitoh
, Aiko Suminoe
, Hiromasa Yabe
, Eichi Azuma
, Yoko Shioda
, Atsushi Ogawa
, Akitoshi Kinoshita
, Hisato Kigasawa
, Yuko Osugi
, Kazutoshi Koike
, Keisei Kawa
, Koji Kato
, Yoshiko Atsuta
, Kazuko Kudo

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

Allogeneic hematopoietic stem cell transplantation (HSCT) has not been widely used in patients with acute myeloid leukemia (AML) and Down syndrome (DS) due to fear of transplantation-related toxicity. A retrospective analysis of the outcome of allogeneic HSCT was conducted in 15 patients with AML and DS. The five patients transplanted with the reduced intensity conditioning (4 in complete remission (CR) and 1 in non-CR) had a significantly better survival rate than 10 patients transplanted with a conventional conditioning (4 in CR and 6 in non-CR) (3-year EFS (95% confidence interval): 80.0% (20.4-96.9%) vs. 10.0% (0.6%-35.8%), P=0.039). Pediatr Blood Cancer 2014;61:925-927.

Original language	English
Pages (from-to)	925-927
Number of pages	3
Journal	Pediatric Blood and Cancer
Volume	61
Issue number	5
DOIs	https://doi.org/10.1002/pbc.24883
Publication status	Published - 05-2014
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Pediatrics, Perinatology, and Child Health
Hematology
Oncology

Access to Document

10.1002/pbc.24883

Cite this

Muramatsu, H., Sakaguchi, H., Taga, T., Tabuchi, K., Adachi, S., Inoue, M., Kitoh, T., Suminoe, A., Yabe, H., Azuma, E., Shioda, Y., Ogawa, A., Kinoshita, A., Kigasawa, H., Osugi, Y., Koike, K., Kawa, K., Kato, K., Atsuta, Y., & Kudo, K. (2014). Reduced intensity conditioning in allogeneic stem cell transplantation for AML with Down syndrome. Pediatric Blood and Cancer, 61(5), 925-927. https://doi.org/10.1002/pbc.24883

@article{ce51630c2d054a089374fb270c6dc7c9,

title = "Reduced intensity conditioning in allogeneic stem cell transplantation for AML with Down syndrome",

abstract = "Allogeneic hematopoietic stem cell transplantation (HSCT) has not been widely used in patients with acute myeloid leukemia (AML) and Down syndrome (DS) due to fear of transplantation-related toxicity. A retrospective analysis of the outcome of allogeneic HSCT was conducted in 15 patients with AML and DS. The five patients transplanted with the reduced intensity conditioning (4 in complete remission (CR) and 1 in non-CR) had a significantly better survival rate than 10 patients transplanted with a conventional conditioning (4 in CR and 6 in non-CR) (3-year EFS (95\% confidence interval): 80.0\% (20.4-96.9\%) vs. 10.0\% (0.6\%-35.8\%), P=0.039). Pediatr Blood Cancer 2014;61:925-927.",

author = "Hideki Muramatsu and Hirotoshi Sakaguchi and Takashi Taga and Ken Tabuchi and Souichi Adachi and Masami Inoue and Toshiyuki Kitoh and Aiko Suminoe and Hiromasa Yabe and Eichi Azuma and Yoko Shioda and Atsushi Ogawa and Akitoshi Kinoshita and Hisato Kigasawa and Yuko Osugi and Kazutoshi Koike and Keisei Kawa and Koji Kato and Yoshiko Atsuta and Kazuko Kudo",

year = "2014",

month = may,

doi = "10.1002/pbc.24883",

language = "English",

volume = "61",

pages = "925--927",

journal = "Pediatric Blood and Cancer",

issn = "1545-5009",

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}

Muramatsu, H, Sakaguchi, H, Taga, T, Tabuchi, K, Adachi, S, Inoue, M, Kitoh, T, Suminoe, A, Yabe, H, Azuma, E, Shioda, Y, Ogawa, A, Kinoshita, A, Kigasawa, H, Osugi, Y, Koike, K, Kawa, K, Kato, K, Atsuta, Y & Kudo, K 2014, 'Reduced intensity conditioning in allogeneic stem cell transplantation for AML with Down syndrome', Pediatric Blood and Cancer, vol. 61, no. 5, pp. 925-927. https://doi.org/10.1002/pbc.24883

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T1 - Reduced intensity conditioning in allogeneic stem cell transplantation for AML with Down syndrome

AU - Muramatsu, Hideki

AU - Sakaguchi, Hirotoshi

AU - Taga, Takashi

AU - Tabuchi, Ken

AU - Adachi, Souichi

AU - Inoue, Masami

AU - Kitoh, Toshiyuki

AU - Suminoe, Aiko

AU - Yabe, Hiromasa

AU - Azuma, Eichi

AU - Shioda, Yoko

AU - Ogawa, Atsushi

AU - Kinoshita, Akitoshi

AU - Kigasawa, Hisato

AU - Osugi, Yuko

AU - Koike, Kazutoshi

AU - Kawa, Keisei

AU - Kato, Koji

AU - Atsuta, Yoshiko

AU - Kudo, Kazuko

PY - 2014/5

Y1 - 2014/5

N2 - Allogeneic hematopoietic stem cell transplantation (HSCT) has not been widely used in patients with acute myeloid leukemia (AML) and Down syndrome (DS) due to fear of transplantation-related toxicity. A retrospective analysis of the outcome of allogeneic HSCT was conducted in 15 patients with AML and DS. The five patients transplanted with the reduced intensity conditioning (4 in complete remission (CR) and 1 in non-CR) had a significantly better survival rate than 10 patients transplanted with a conventional conditioning (4 in CR and 6 in non-CR) (3-year EFS (95% confidence interval): 80.0% (20.4-96.9%) vs. 10.0% (0.6%-35.8%), P=0.039). Pediatr Blood Cancer 2014;61:925-927.

AB - Allogeneic hematopoietic stem cell transplantation (HSCT) has not been widely used in patients with acute myeloid leukemia (AML) and Down syndrome (DS) due to fear of transplantation-related toxicity. A retrospective analysis of the outcome of allogeneic HSCT was conducted in 15 patients with AML and DS. The five patients transplanted with the reduced intensity conditioning (4 in complete remission (CR) and 1 in non-CR) had a significantly better survival rate than 10 patients transplanted with a conventional conditioning (4 in CR and 6 in non-CR) (3-year EFS (95% confidence interval): 80.0% (20.4-96.9%) vs. 10.0% (0.6%-35.8%), P=0.039). Pediatr Blood Cancer 2014;61:925-927.

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U2 - 10.1002/pbc.24883

DO - 10.1002/pbc.24883

M3 - Article

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AN - SCOPUS:84895745117

SN - 1545-5009

VL - 61

SP - 925

EP - 927

JO - Pediatric Blood and Cancer

JF - Pediatric Blood and Cancer

IS - 5

ER -

Reduced intensity conditioning in allogeneic stem cell transplantation for AML with Down syndrome

Abstract

UN SDGs

All Science Journal Classification (ASJC) codes

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