Reduced susceptibility to cefepime among Escherichia coli clinical isolates producing novel variants of CMY-2 β-lactamase

Yohei Doi; David L. Paterson; Jennifer M. Adams-Haduch; Hanna E. Sidjabat; Alexandra O'Keefe; Andrea Endimiani; Robert A. Bonomo

doi:10.1128/AAC.00133-09

Reduced susceptibility to cefepime among Escherichia coli clinical isolates producing novel variants of CMY-2 β-lactamase

Yohei Doi, David L. Paterson, Jennifer M. Adams-Haduch, Hanna E. Sidjabat, Alexandra O'Keefe, Andrea Endimiani, Robert A. Bonomo

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Abstract

Here we describe three Escherichia coli clinical isolates with reduced susceptibility to cefepime. Sequencing of the bla_CMY genes revealed two novel variants (CMY-33 and -44) with two- to four-amino-acid deletions in the H-10 helix. The deletions were responsible for 12- to 24-fold increases in the MICs of cefepime.

Original language	English
Pages (from-to)	3159-3161
Number of pages	3
Journal	Antimicrobial agents and chemotherapy
Volume	53
Issue number	7
DOIs	https://doi.org/10.1128/AAC.00133-09
Publication status	Published - 07-2009
Externally published	Yes

All Science Journal Classification (ASJC) codes

Pharmacology
Pharmacology (medical)
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1128/AAC.00133-09

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title = "Reduced susceptibility to cefepime among Escherichia coli clinical isolates producing novel variants of CMY-2 β-lactamase",

abstract = "Here we describe three Escherichia coli clinical isolates with reduced susceptibility to cefepime. Sequencing of the blaCMY genes revealed two novel variants (CMY-33 and -44) with two- to four-amino-acid deletions in the H-10 helix. The deletions were responsible for 12- to 24-fold increases in the MICs of cefepime.",

author = "Yohei Doi and Paterson, {David L.} and Adams-Haduch, {Jennifer M.} and Sidjabat, {Hanna E.} and Alexandra O'Keefe and Andrea Endimiani and Bonomo, {Robert A.}",

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language = "English",

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AU - Doi, Yohei

AU - Paterson, David L.

AU - Adams-Haduch, Jennifer M.

AU - Sidjabat, Hanna E.

AU - O'Keefe, Alexandra

AU - Endimiani, Andrea

AU - Bonomo, Robert A.

PY - 2009/7

Y1 - 2009/7

N2 - Here we describe three Escherichia coli clinical isolates with reduced susceptibility to cefepime. Sequencing of the blaCMY genes revealed two novel variants (CMY-33 and -44) with two- to four-amino-acid deletions in the H-10 helix. The deletions were responsible for 12- to 24-fold increases in the MICs of cefepime.

AB - Here we describe three Escherichia coli clinical isolates with reduced susceptibility to cefepime. Sequencing of the blaCMY genes revealed two novel variants (CMY-33 and -44) with two- to four-amino-acid deletions in the H-10 helix. The deletions were responsible for 12- to 24-fold increases in the MICs of cefepime.

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IS - 7

ER -

Reduced susceptibility to cefepime among Escherichia coli clinical isolates producing novel variants of CMY-2 β-lactamase

Abstract

All Science Journal Classification (ASJC) codes

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