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Reduced susceptibility to cefepime among Escherichia coli clinical isolates producing novel variants of CMY-2 β-lactamase

  • Yohei Doi
  • , David L. Paterson
  • , Jennifer M. Adams-Haduch
  • , Hanna E. Sidjabat
  • , Alexandra O'Keefe
  • , Andrea Endimiani
  • , Robert A. Bonomo

Research output: Contribution to journal › Article › peer-review

Abstract

Here we describe three Escherichia coli clinical isolates with reduced susceptibility to cefepime. Sequencing of the blaCMY genes revealed two novel variants (CMY-33 and -44) with two- to four-amino-acid deletions in the H-10 helix. The deletions were responsible for 12- to 24-fold increases in the MICs of cefepime.

Original languageEnglish
Pages (from-to)3159-3161
Number of pages3
JournalAntimicrobial agents and chemotherapy
Volume53
Issue number7
DOIs
Publication statusPublished - 07-2009
Externally publishedYes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

  1. SDG 3 - Good Health and Well-being
    SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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