Reduction of Alzheimer's disease amyloid-β in plasma by hemodialysis and its relation to cognitive functions

N. Kitaguchi; K. Kawaguchi; S. Nakai; K. Murakami; S. Ito; H. Hoshino; H. Hori; A. Ohashi; Y. Shimano; N. Suzuki; Y. Yuzawa; T. Mutoh; S. Sugiyama

doi:10.1159/000322624

Reduction of Alzheimer's disease amyloid-β in plasma by hemodialysis and its relation to cognitive functions

N. Kitaguchi, K. Kawaguchi, S. Nakai, K. Murakami, S. Ito, H. Hoshino, H. Hori, A. Ohashi, Y. Shimano, N. Suzuki, Y. Yuzawa, T. Mutoh, S. Sugiyama

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

Background/Aims: Rapid removal of plasma amyloid-β (Aβ) by blood purification may serve as a peripheral Aβ sink from the brain for Alzheimer's disease therapy. We investigated the reduction of plasma Aβ during hemodialysis and cognitive states. Methods: Aβ concentrations and Mini-Mental State Examinations (MMSE) were investigated in 37 hemodialysis patients (68.9 ± 4.1 years). Results: The dialyzers effectively removed Aβ_1-40 and Aβ_1-42, 63.9 ± 14.4 and 51.6 ± 17.0% at 4 h dialysis, resulting in the reduction of Aβs in whole-body circulation by 51.1 ± 8.9 and 32.7 ± 12.0%, respectively. Although the plasma Aβs before dialysis (750.8 ± 171.3 pg/ml for Aβ_1-40) were higher than those reported for Alzheimer's disease patients, the cognitive states of hemodialysis patients were relatively normal, especially of longer dialysis vintages. Conclusions: Dialyzers effectively reduced Aβs in whole-body circulation. Repeated rapid decrease of plasma Aβs might maintain cognitive state.

Original language	English
Pages (from-to)	57-62
Number of pages	6
Journal	Blood Purification
Volume	32
Issue number	1
DOIs	https://doi.org/10.1159/000322624
Publication status	Published - 07-2011

All Science Journal Classification (ASJC) codes

Hematology
Nephrology

Access to Document

10.1159/000322624

Cite this

@article{cadb6677e4074cbcb31a48d00c4c0f95,

title = "Reduction of Alzheimer's disease amyloid-β in plasma by hemodialysis and its relation to cognitive functions",

abstract = "Background/Aims: Rapid removal of plasma amyloid-β (Aβ) by blood purification may serve as a peripheral Aβ sink from the brain for Alzheimer's disease therapy. We investigated the reduction of plasma Aβ during hemodialysis and cognitive states. Methods: Aβ concentrations and Mini-Mental State Examinations (MMSE) were investigated in 37 hemodialysis patients (68.9 ± 4.1 years). Results: The dialyzers effectively removed Aβ1-40 and Aβ1-42, 63.9 ± 14.4 and 51.6 ± 17.0% at 4 h dialysis, resulting in the reduction of Aβs in whole-body circulation by 51.1 ± 8.9 and 32.7 ± 12.0%, respectively. Although the plasma Aβs before dialysis (750.8 ± 171.3 pg/ml for Aβ1-40) were higher than those reported for Alzheimer's disease patients, the cognitive states of hemodialysis patients were relatively normal, especially of longer dialysis vintages. Conclusions: Dialyzers effectively reduced Aβs in whole-body circulation. Repeated rapid decrease of plasma Aβs might maintain cognitive state.",

author = "N. Kitaguchi and K. Kawaguchi and S. Nakai and K. Murakami and S. Ito and H. Hoshino and H. Hori and A. Ohashi and Y. Shimano and N. Suzuki and Y. Yuzawa and T. Mutoh and S. Sugiyama",

year = "2011",

month = jul,

doi = "10.1159/000322624",

language = "English",

volume = "32",

pages = "57--62",

journal = "Blood Purification",

issn = "0253-5068",

publisher = "S. Karger AG",

number = "1",

}

TY - JOUR

T1 - Reduction of Alzheimer's disease amyloid-β in plasma by hemodialysis and its relation to cognitive functions

AU - Kitaguchi, N.

AU - Kawaguchi, K.

AU - Nakai, S.

AU - Murakami, K.

AU - Ito, S.

AU - Hoshino, H.

AU - Hori, H.

AU - Ohashi, A.

AU - Shimano, Y.

AU - Suzuki, N.

AU - Yuzawa, Y.

AU - Mutoh, T.

AU - Sugiyama, S.

PY - 2011/7

Y1 - 2011/7

N2 - Background/Aims: Rapid removal of plasma amyloid-β (Aβ) by blood purification may serve as a peripheral Aβ sink from the brain for Alzheimer's disease therapy. We investigated the reduction of plasma Aβ during hemodialysis and cognitive states. Methods: Aβ concentrations and Mini-Mental State Examinations (MMSE) were investigated in 37 hemodialysis patients (68.9 ± 4.1 years). Results: The dialyzers effectively removed Aβ1-40 and Aβ1-42, 63.9 ± 14.4 and 51.6 ± 17.0% at 4 h dialysis, resulting in the reduction of Aβs in whole-body circulation by 51.1 ± 8.9 and 32.7 ± 12.0%, respectively. Although the plasma Aβs before dialysis (750.8 ± 171.3 pg/ml for Aβ1-40) were higher than those reported for Alzheimer's disease patients, the cognitive states of hemodialysis patients were relatively normal, especially of longer dialysis vintages. Conclusions: Dialyzers effectively reduced Aβs in whole-body circulation. Repeated rapid decrease of plasma Aβs might maintain cognitive state.

AB - Background/Aims: Rapid removal of plasma amyloid-β (Aβ) by blood purification may serve as a peripheral Aβ sink from the brain for Alzheimer's disease therapy. We investigated the reduction of plasma Aβ during hemodialysis and cognitive states. Methods: Aβ concentrations and Mini-Mental State Examinations (MMSE) were investigated in 37 hemodialysis patients (68.9 ± 4.1 years). Results: The dialyzers effectively removed Aβ1-40 and Aβ1-42, 63.9 ± 14.4 and 51.6 ± 17.0% at 4 h dialysis, resulting in the reduction of Aβs in whole-body circulation by 51.1 ± 8.9 and 32.7 ± 12.0%, respectively. Although the plasma Aβs before dialysis (750.8 ± 171.3 pg/ml for Aβ1-40) were higher than those reported for Alzheimer's disease patients, the cognitive states of hemodialysis patients were relatively normal, especially of longer dialysis vintages. Conclusions: Dialyzers effectively reduced Aβs in whole-body circulation. Repeated rapid decrease of plasma Aβs might maintain cognitive state.

UR - http://www.scopus.com/inward/record.url?scp=79951854134&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79951854134&partnerID=8YFLogxK

U2 - 10.1159/000322624

DO - 10.1159/000322624

M3 - Article

C2 - 21346337

AN - SCOPUS:79951854134

SN - 0253-5068

VL - 32

SP - 57

EP - 62

JO - Blood Purification

JF - Blood Purification

IS - 1

ER -

Reduction of Alzheimer's disease amyloid-β in plasma by hemodialysis and its relation to cognitive functions

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this