Reduction of Alzheimer's disease amyloid-β in plasma by hemodialysis and its relation to cognitive functions

Nobuya Kitaguchi, K. Kawaguchi, S. Nakai, K. Murakami, S. Ito, H. Hoshino, H. Hori, A. Ohashi, Y. Shimano, N. Suzuki, Y. Yuzawa, T. Mutoh, S. Sugiyama

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19 Citations (Scopus)

Abstract

Background/Aims: Rapid removal of plasma amyloid-β (Aβ) by blood purification may serve as a peripheral Aβ sink from the brain for Alzheimer's disease therapy. We investigated the reduction of plasma Aβ during hemodialysis and cognitive states. Methods: Aβ concentrations and Mini-Mental State Examinations (MMSE) were investigated in 37 hemodialysis patients (68.9 ± 4.1 years). Results: The dialyzers effectively removed Aβ1-40 and Aβ1-42, 63.9 ± 14.4 and 51.6 ± 17.0% at 4 h dialysis, resulting in the reduction of Aβs in whole-body circulation by 51.1 ± 8.9 and 32.7 ± 12.0%, respectively. Although the plasma Aβs before dialysis (750.8 ± 171.3 pg/ml for Aβ1-40) were higher than those reported for Alzheimer's disease patients, the cognitive states of hemodialysis patients were relatively normal, especially of longer dialysis vintages. Conclusions: Dialyzers effectively reduced Aβs in whole-body circulation. Repeated rapid decrease of plasma Aβs might maintain cognitive state.

Original languageEnglish
Pages (from-to)57-62
Number of pages6
JournalBlood Purification
Volume32
Issue number1
DOIs
Publication statusPublished - 01-07-2011

All Science Journal Classification (ASJC) codes

  • Hematology
  • Nephrology

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