Reference ranges for serum cystatin C measurements in Japanese children by using 4 automated assays

Nahoko Yata, Osamu Uemura, Masataka Honda, Takeshi Matsuyama, Kenji Ishikura, Hiroshi Hataya, Takuhito Nagai, Yohei Ikezumi, Naoya Fujita, Shuichi Ito, Kazumoto Iijima, Mari Saito, Tetsuji Keneko, Teruo Kitagawa

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10 Citations (Scopus)

Abstract

Objective: The data available on reference ranges for cystatin C in children are limited, and there are discrepancies among the available data. The aim of this study was to describe the reference ranges for cystatin C in Japanese children by using 4 automated assays. Methods: Serum cystatin C levels were measured in 1128 Japanese children aged 3 month to 16 years without kidney disease. We calculated age-, gender-, race- and assay-specific cystatin C ranges. Results: For all 4 assays, the median serum cystatin C levels were raised in term infants compared with older children and decreased by the first 2 years. The median serum cystatin C levels remained constant throughout up to the age of 14 years and decreased in children aged 15-16 years. The median serum cystatin C levels in children aged 12-16 years were slightly higher in males than in females. Assay-specific differences were also observed in the levels of serum cystatin C measured. Conclusion: Age-, gender-, race- and assay-specific ranges for serum cystatin C should be used as another tool to assess kidney function in children.

Original languageEnglish
Pages (from-to)872-876
Number of pages5
JournalClinical and Experimental Nephrology
Volume17
Issue number6
DOIs
Publication statusPublished - 01-12-2013
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Physiology
  • Nephrology
  • Physiology (medical)

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    Yata, N., Uemura, O., Honda, M., Matsuyama, T., Ishikura, K., Hataya, H., Nagai, T., Ikezumi, Y., Fujita, N., Ito, S., Iijima, K., Saito, M., Keneko, T., & Kitagawa, T. (2013). Reference ranges for serum cystatin C measurements in Japanese children by using 4 automated assays. Clinical and Experimental Nephrology, 17(6), 872-876. https://doi.org/10.1007/s10157-013-0784-x