TY - JOUR
T1 - Reference ranges for serum cystatin C measurements in Japanese children by using 4 automated assays
AU - Yata, Nahoko
AU - Uemura, Osamu
AU - Honda, Masataka
AU - Matsuyama, Takeshi
AU - Ishikura, Kenji
AU - Hataya, Hiroshi
AU - Nagai, Takuhito
AU - Ikezumi, Yohei
AU - Fujita, Naoya
AU - Ito, Shuichi
AU - Iijima, Kazumoto
AU - Saito, Mari
AU - Keneko, Tetsuji
AU - Kitagawa, Teruo
N1 - Funding Information:
This study was financially supported by the Kidney Foundation, Japan. We thank Midori Awazu, MD; Takashi Sekine, MD; Mayumi Sako, MD; Takuji Yamada, MD; and Yuko Akioka, MD of the Committee of Measures for Pediatric CKD, for their contributions to the conception and design of this study. None of the funding sources had any role in the design or conduct of the study; in the collection, management, analysis, or interpretation of the data, or in the preparation, review, or approval of this manuscript. The authors declare that no conflict of interest exists.
PY - 2013/12
Y1 - 2013/12
N2 - Objective: The data available on reference ranges for cystatin C in children are limited, and there are discrepancies among the available data. The aim of this study was to describe the reference ranges for cystatin C in Japanese children by using 4 automated assays. Methods: Serum cystatin C levels were measured in 1128 Japanese children aged 3 month to 16 years without kidney disease. We calculated age-, gender-, race- and assay-specific cystatin C ranges. Results: For all 4 assays, the median serum cystatin C levels were raised in term infants compared with older children and decreased by the first 2 years. The median serum cystatin C levels remained constant throughout up to the age of 14 years and decreased in children aged 15-16 years. The median serum cystatin C levels in children aged 12-16 years were slightly higher in males than in females. Assay-specific differences were also observed in the levels of serum cystatin C measured. Conclusion: Age-, gender-, race- and assay-specific ranges for serum cystatin C should be used as another tool to assess kidney function in children.
AB - Objective: The data available on reference ranges for cystatin C in children are limited, and there are discrepancies among the available data. The aim of this study was to describe the reference ranges for cystatin C in Japanese children by using 4 automated assays. Methods: Serum cystatin C levels were measured in 1128 Japanese children aged 3 month to 16 years without kidney disease. We calculated age-, gender-, race- and assay-specific cystatin C ranges. Results: For all 4 assays, the median serum cystatin C levels were raised in term infants compared with older children and decreased by the first 2 years. The median serum cystatin C levels remained constant throughout up to the age of 14 years and decreased in children aged 15-16 years. The median serum cystatin C levels in children aged 12-16 years were slightly higher in males than in females. Assay-specific differences were also observed in the levels of serum cystatin C measured. Conclusion: Age-, gender-, race- and assay-specific ranges for serum cystatin C should be used as another tool to assess kidney function in children.
UR - https://www.scopus.com/pages/publications/84891489311
UR - https://www.scopus.com/pages/publications/84891489311#tab=citedBy
U2 - 10.1007/s10157-013-0784-x
DO - 10.1007/s10157-013-0784-x
M3 - Article
C2 - 23446519
AN - SCOPUS:84891489311
SN - 1342-1751
VL - 17
SP - 872
EP - 876
JO - Clinical and Experimental Nephrology
JF - Clinical and Experimental Nephrology
IS - 6
ER -