Refined mapping of eight cosmid markers on human chromosome 22

Hiroki Kurahashi, Kenzo Akagi, Ikuo Yana, Thomas Melot, Olivier Delattre, Gilles Thomas, Shintaro Okada, Shin ichiro Takai, Isamu Nishisho

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Eight cosmid clones were regionally assigned to small subregions of chromosome 22 by hybridization with a total of 22 somatic cell hybrids. One cosmid was localized to the proximal part of 22q which contained the region commonly deleted in the DiGeorge syndrome. Seven cosmids showing restriction fragment length polymorphisms were localized to the telomeric region distal to the MB locus, which was reported to be frequently deleted in sporadic meningioma. These cosmids, when finely mapped and ordered, are considered useful for the identification of genetic alterations on this chromosome arm.

Original languageEnglish
Pages (from-to)243-248
Number of pages6
JournalThe Japanese Journal of Human Genetics
Volume39
Issue number2
DOIs
Publication statusPublished - 06-1994

All Science Journal Classification (ASJC) codes

  • Genetics(clinical)

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  • Cite this

    Kurahashi, H., Akagi, K., Yana, I., Melot, T., Delattre, O., Thomas, G., Okada, S., Takai, S. I., & Nishisho, I. (1994). Refined mapping of eight cosmid markers on human chromosome 22. The Japanese Journal of Human Genetics, 39(2), 243-248. https://doi.org/10.1007/BF01876844