TY - JOUR
T1 - Refractive error and biometrics of anterior segment of eyes of healthy young university students in Japan
AU - Kato, Kumiko
AU - Kondo, Mineo
AU - Takeuchi, Maki
AU - Hirano, Koji
N1 - Funding Information:
We thank Eriko Uchiyama, Miharu Kitamura, Daisuke Kurose, Ryunosuke Nagashima, Takumi Ohashi, Sayo Morita, Asako Sugawara for performing ophthalmologic examinations in our subjects. We thank Norio Sugimoto of the Sugimoto data analysis service for critical discussion on statistical analysis. We also thank Professor Emeritus Duco I. Hamasaki of the Bascom Palmer Eye Institute of the University of Miami (Miami, FL, USA) for critical discussion and final manuscript revisions. KK received honoraria from Alcon, Eizai, Otsuka, and Santen. MK is a consultant to Senjyu, and received financial research support from Alcon, Hoya, Nidek, Novartis, Otsuka, Pfizer, Santen, and Senjyu, and honoraria from Alcon, Bayer, Hoya, Nidek, Novarits, Otsuka, Pfizer, Sanofi, Santen, Sanwa, and Senjyu. KH and MT has no financial disclosures. Grant-in-Aid for Scientific Research C (KK, 16K11266; MK, 26462683) from Ministry of Education, Culture, Sports, Science and Technology. (http:// www.jsps.go.jp/).
PY - 2019/12/1
Y1 - 2019/12/1
N2 - To determine the parameters of the anterior segment of eyes that are significantly associated with the refractive error in healthy young Japanese university students. This was a cross-sectional observational study of 229 healthy Japanese university students (men: women,147:82) whose age ranged between 20 to 29 years. Univariate and multivariate linear regression analyses were performed to identify the factors that were significantly correlated with the refractive error. The independent variables included age, sex, axial length, anterior chamber depth, corneal diameter, curvature of anterior surface of cornea, and central corneal thickness. The mean refractive error (spherical equivalent) was −4.1 ± 2.7 diopters (D) with a range of −12.5 to +0.5 D, and the mean axial length was 25.4 ± 1.3 mm with a range of 22.4 to 29.0 mm. Pearson univariate correlation analysis found that the refractive error was significantly and negatively correlated with the axial length (R = −0.82, P < 0.001), deeper anterior chamber (R = −0.30, P < 0.001), and larger corneal diameter (R = −0.21, P = 0.001). Multiple regression analysis showed that the refractive error was significantly associated with a longer axial length (P < 0.001), a deeper anterior chamber (P < 0.001), and a flatter corneal curvature (P < 0.001).The biometric values of the anterior segment of the eyes should make the eye more hyperopic which would reduce the myopia-inducing lengthening of the axial length.
AB - To determine the parameters of the anterior segment of eyes that are significantly associated with the refractive error in healthy young Japanese university students. This was a cross-sectional observational study of 229 healthy Japanese university students (men: women,147:82) whose age ranged between 20 to 29 years. Univariate and multivariate linear regression analyses were performed to identify the factors that were significantly correlated with the refractive error. The independent variables included age, sex, axial length, anterior chamber depth, corneal diameter, curvature of anterior surface of cornea, and central corneal thickness. The mean refractive error (spherical equivalent) was −4.1 ± 2.7 diopters (D) with a range of −12.5 to +0.5 D, and the mean axial length was 25.4 ± 1.3 mm with a range of 22.4 to 29.0 mm. Pearson univariate correlation analysis found that the refractive error was significantly and negatively correlated with the axial length (R = −0.82, P < 0.001), deeper anterior chamber (R = −0.30, P < 0.001), and larger corneal diameter (R = −0.21, P = 0.001). Multiple regression analysis showed that the refractive error was significantly associated with a longer axial length (P < 0.001), a deeper anterior chamber (P < 0.001), and a flatter corneal curvature (P < 0.001).The biometric values of the anterior segment of the eyes should make the eye more hyperopic which would reduce the myopia-inducing lengthening of the axial length.
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U2 - 10.1038/s41598-019-51920-4
DO - 10.1038/s41598-019-51920-4
M3 - Article
C2 - 31653953
AN - SCOPUS:85074157569
VL - 9
JO - Scientific Reports
JF - Scientific Reports
SN - 2045-2322
IS - 1
M1 - 15337
ER -