Abstract
Granulocyte and monocyte adsorptive apheresis (GMA) is occasionally introduced as an alternative combination therapy after loss of response to biologics in ulcerative colitis (UC) patients. However, there have been no reports of the concomitant use of vedolizumab (VDZ) and GMA for the initial induction of UC. A 20- year-old man with refractory UC was admitted for recrudescence. VDZ monotherapy had previously been introduced but was ineffective. Therefore, he received scheduled combination of VDZ and GMA and achieved clinical remission. The combination of two different approaches to inhibit the migration of leukocytes into the inflamed tissue led to satisfactory clinical outcomes.
Original language | English |
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Pages (from-to) | 3009-3014 |
Number of pages | 6 |
Journal | Internal Medicine |
Volume | 59 |
Issue number | 23 |
DOIs | |
Publication status | Published - 01-12-2020 |
Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Internal Medicine