Regulation and functions of Rho-associated kinase

Mutsuki Amano, Yuko Fukata, Kozo Kaibuchi

Research output: Contribution to journalArticlepeer-review

450 Citations (Scopus)


Remarkable progress has been made in understanding effector molecules of small GTPase Rho, especially Rho-associated kinase (Rho-kinase/ROK/ROCK), in the past 5 years. Rho-associated kinase appears to mediate a large proportion of the signals from Rho and regulate dynamic reorganization of cytoskeletal proteins, such as stress fiber and focal adhesion formation. Several substrates of Rho-associated kinase have been reported and their cellular functions unraveled. In this review, we focus on the regulation and cellular functions of Rho-associated kinase. (C) 2000 Academic Press.

Original languageEnglish
Pages (from-to)44-51
Number of pages8
JournalExperimental Cell Research
Issue number1
Publication statusPublished - 25-11-2000
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Cell Biology


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