TY - JOUR
T1 - Regulation and functions of Rho-associated kinase
AU - Amano, Mutsuki
AU - Fukata, Yuko
AU - Kaibuchi, Kozo
N1 - Funding Information:
Preparation of this review was supported by grants-in-aid for scientific research from the Ministry of Education, Science, and Culture of Japan; by the Research for the Future Program from the Japan Society for the Promotion of Science; and by a grant from the Human Frontier Science Program Organization. We thank Drs. M. Ito (Mie University), H. Shimokawa (Kyusyu University), and K. Fujiwara (University of Rochester) for preparing this review. We are grateful to M. Maeda for secretarial assistance.
PY - 2000/11/25
Y1 - 2000/11/25
N2 - Remarkable progress has been made in understanding effector molecules of small GTPase Rho, especially Rho-associated kinase (Rho-kinase/ROK/ROCK), in the past 5 years. Rho-associated kinase appears to mediate a large proportion of the signals from Rho and regulate dynamic reorganization of cytoskeletal proteins, such as stress fiber and focal adhesion formation. Several substrates of Rho-associated kinase have been reported and their cellular functions unraveled. In this review, we focus on the regulation and cellular functions of Rho-associated kinase. (C) 2000 Academic Press.
AB - Remarkable progress has been made in understanding effector molecules of small GTPase Rho, especially Rho-associated kinase (Rho-kinase/ROK/ROCK), in the past 5 years. Rho-associated kinase appears to mediate a large proportion of the signals from Rho and regulate dynamic reorganization of cytoskeletal proteins, such as stress fiber and focal adhesion formation. Several substrates of Rho-associated kinase have been reported and their cellular functions unraveled. In this review, we focus on the regulation and cellular functions of Rho-associated kinase. (C) 2000 Academic Press.
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U2 - 10.1006/excr.2000.5046
DO - 10.1006/excr.2000.5046
M3 - Article
C2 - 11082274
AN - SCOPUS:0034715885
VL - 261
SP - 44
EP - 51
JO - Experimental Cell Research
JF - Experimental Cell Research
SN - 0014-4827
IS - 1
ER -