Abstract
Remarkable progress has been made in understanding effector molecules of small GTPase Rho, especially Rho-associated kinase (Rho-kinase/ROK/ROCK), in the past 5 years. Rho-associated kinase appears to mediate a large proportion of the signals from Rho and regulate dynamic reorganization of cytoskeletal proteins, such as stress fiber and focal adhesion formation. Several substrates of Rho-associated kinase have been reported and their cellular functions unraveled. In this review, we focus on the regulation and cellular functions of Rho-associated kinase. (C) 2000 Academic Press.
Original language | English |
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Pages (from-to) | 44-51 |
Number of pages | 8 |
Journal | Experimental Cell Research |
Volume | 261 |
Issue number | 1 |
DOIs | |
Publication status | Published - 25-11-2000 |
Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Cell Biology