Regulation of cadherin-mediated cell-cell adhesion by the rho family GTPases

Kozo Kaibuchi, Shinya Kuroda, Masaki Fukata, Masato Nakagawa

Research output: Contribution to journalReview articlepeer-review

169 Citations (Scopus)


Reports in the past two years have shown that Cdc42, Rac1, and Rho - belonging to the Rho small GTPase family - participate in the regulation of cadherin-mediated cell-cell adhesion, IQGAP1, an effector of Cdc42 and Rac1, interacts with cadherin and β-catenin and induces the dissociation of α-catenin from the cadherin-catenins complex leading to disruption of cell-cell adhesion: activated Cdc42 and Rac1 counteract the effect of IQGAP1. Thus, Cdc42 and Rac1 appear to regulate cadherin-mediated cell-cell adhesion acting through IQGAP1.

Original languageEnglish
Pages (from-to)591-596
Number of pages6
JournalCurrent Opinion in Cell Biology
Issue number5
Publication statusPublished - 01-10-1999
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Cell Biology


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