Regulation of cadherin-mediated cell-cell adhesion by the rho family GTPases

Reports in the past two years have shown that Cdc42, Rac1, and Rho - belonging to the Rho small GTPase family - participate in the regulation of cadherin-mediated cell-cell adhesion, IQGAP1, an effector of Cdc42 and Rac1, interacts with cadherin and β-catenin and induces the dissociation of α-catenin from the cadherin-catenins complex leading to disruption of cell-cell adhesion: activated Cdc42 and Rac1 counteract the effect of IQGAP1. Thus, Cdc42 and Rac1 appear to regulate cadherin-mediated cell-cell adhesion acting through IQGAP1.