Regulation of Epstein-Barr virus reactivation from latency

Research output: Contribution to journalReview article

45 Citations (Scopus)

Abstract

The Epstein-Barr virus (EBV) is a human gamma-herpesvirus that is implicated in various types of proliferative diseases. Upon infection, it predominantly establishes latency in B cells and cannot ever be eradicated; it persists for the host's lifetime. Reactivation of the virus from latency depends on expression of the viral immediate-early gene, BamHI Z fragment leftward open reading frame 1 (BZLF1). The BZLF1 promoter normally exhibits only low basal activity but is activated in response to chemical or biological inducers, such as 12-O-tetradecanoylphorbol-13-acetate, calcium ionophore, histone deacetylase inhibitor, or anti-Ig. Transcription from the BZLF1 promoter is activated by myocyte enhancer factor 2, specificity protein 1, b-Zip type transcription factors and mediating epigenetic modifications of the promoter, such as histone acetylation and H3K4me3. In contrast, repression of the promoter is mediated by transcriptional suppressors, such as ZEB, ZIIR-BP, and jun dimerization protein 2, causing suppressive histone modifications like histone H3K27me3, H3K9me2/3 and H4K20me3. Interestingly, there is little CpG DNA methylation of the promoter, indicating that DNA methylation is not crucial for suppression of BZLF1. This review will focus on the molecular mechanisms by which the EBV lytic switch is controlled and discuss the physiological significance of this switching for its survival and oncogenesis.

Original languageEnglish
Pages (from-to)307-317
Number of pages11
JournalMICROBIOLOGY and IMMUNOLOGY
Volume58
Issue number6
DOIs
Publication statusPublished - 06-2014

Fingerprint

Virus Latency
Human Herpesvirus 4
Open Reading Frames
DNA Methylation
Histones
Histone Code
MEF2 Transcription Factors
Protein Multimerization
Histone Deacetylase Inhibitors
Immediate-Early Genes
Viral Genes
Calcium Ionophores
Herpesviridae
Tetradecanoylphorbol Acetate
Acetylation
Epigenomics
Carcinogenesis
B-Lymphocytes
Transcription Factors
Survival

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Immunology
  • Virology

Cite this

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Regulation of Epstein-Barr virus reactivation from latency. / Murata, Takayuki.

In: MICROBIOLOGY and IMMUNOLOGY, Vol. 58, No. 6, 06.2014, p. 307-317.

Research output: Contribution to journalReview article

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