Regulation of HNK-1 (Human Natural Killer-1) Carbohydrate Expression: Multiple Control Mechanisms of Biosynthetic Enzyme Activity

Yasuhiko Kizuka, Shogo Oka

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

HNK-1 carbohydrate is highly expressed in the nervous system and is involved in higher-order brain functions such as learning and memory. HNK-1 has a unique structure with sulfated glucuronic acid attached to the non-reducing end of N-acetyllactosamine (HSO3-3GlcA β1-3Gal β1-4GlcNAc-). Two glucuronyltransferases and a sulfotransferase play key roles in its biosynthesis. We focused on how these enzyme activities are regulated in terms of HNK-1 expression. We revealed that the transferases form a hetero-complex for the efficient biosynthesis and that the activity is regulated by well-controlled intracellular localization. These facts indicate that HNK-1 expression is strictly regulated through multiple control mechanisms of the biosynthetic enzyme activity.

Original languageEnglish
Pages (from-to)194-199
Number of pages6
JournalTrends in Glycoscience and Glycotechnology
Volume22
Issue number126
DOIs
Publication statusPublished - 2010
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Organic Chemistry

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