Regulation of neuronal migration, an emerging topic in autism spectrum disorders

Orly Reiner, Eyal Karzbrun, Aditya Kshirsagar, Kozo Kaibuchi

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Autism spectrum disorders (ASD) encompass a group of neurodevelopmental diseases that demonstrate strong heritability, however, the inheritance is not simple and many genes have been associated with these disorders. ASD is regarded as a neurodevelopmental disorder, and abnormalities at different developmental stages are part of the disease etiology. This review provides a general background on neuronal migration during brain development and discusses recent advancements in the field connecting ASD and aberrant neuronal migration. We propose that neuronal migration impairment may be an important common pathophysiology in autism spectrum disorders (ASD). This review provides a general background on neuronal migration during brain development and discusses recent advancements in the field connecting ASD and aberrant neuronal migration. We propose that neuronal migration impairment may be an important common pathophysiology in autism spectrum disorders (ASD). This review provides a general background on neuronal migration during brain development and discusses recent advancements in the field connecting ASD and aberrant neuronal migration.

Original languageEnglish
Pages (from-to)440-456
Number of pages17
JournalJournal of neurochemistry
Volume136
Issue number3
DOIs
Publication statusPublished - 01-02-2016

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Cellular and Molecular Neuroscience

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