Relation of a common variant of the adiponectin gene to serum adiponectin concentration and metabolic traits in an aged Japanese population

Daisuke Tanimura, Rei Shibata, Hideo Izawa, Akihiro Hirashiki, Hiroyuki Asano, Yosuke Murase, Seiko Miyata, Masahiro Nakatochi, Noriyuki Ouchi, Sahoko Ichihara, Kenji Yasui, Tsutomu Yoshida, Keiko Naruse, Tatsuaki Matsubara, Mitsuhiro Yokota

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Abstract

Adiponectin is an adipocyte-derived protein that is down-regulated in obesity-linked disorders. Variants of the adiponectin gene (ADIPOQ) have been shown to affect adiponectin level. We have now examined the relation of polymorphisms of ADIPOQ to adiponectin concentration and to metabolic disorders in the Kita-Nagoya Genomic Epidemiology study, a population-based study of elderly Japanese. The genomic region including ADIPOQ was genotyped for 30 single nucleotide polymorphisms in 500 subjects of a screening population with the use of a fluorescence- or colorimetry-based allele-specific DNA primer-probe assay system. Four polymorphisms were then selected for genotyping in an additional 2797 subjects. Serum adiponectin level was negatively associated with metabolic abnormalities after adjustment for age and sex. The minor alleles of the rs1656930, Ile164Thr, and rs9882205 polymorphisms were associated with a low serum adiponectin level. Whereas the minor alleles of rs1656930 and rs9882205 were common (minor allele frequency of 6.2 and 38.5%, respectively), that of Ile164Thr was rare (0.9%). The minor allele of rs1656930 was positively associated with systolic blood pressure and the prevalence of hypertension. The association of rs1656930 with adiponectin level was replicated in an independent population. A subject with the 164Thr/Thr genotype had an extremely low serum adiponectin level (0.6 g/ml) and the phenotype of metabolic syndrome. Our results suggest that a common variant of ADIPOQ, the minor allele of rs1656930, is associated with hypoadiponectinemia and hypertension. Screening for a common genetic background underlying low adiponectin levels might provide important information for assessment and management of metabolic disorders.

Original languageEnglish
Pages (from-to)262-269
Number of pages8
JournalEuropean Journal of Human Genetics
Volume19
Issue number3
DOIs
Publication statusPublished - 01-03-2011

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Adiponectin
Serum
Population
Genes
Alleles
Blood Pressure
Hypertension
Colorimetry
Information Management
DNA Primers
DNA Probes
Adipocytes
Gene Frequency
Single Nucleotide Polymorphism
Epidemiology
Obesity
Fluorescence
Genotype
Phenotype

All Science Journal Classification (ASJC) codes

  • Genetics
  • Genetics(clinical)

Cite this

Tanimura, Daisuke ; Shibata, Rei ; Izawa, Hideo ; Hirashiki, Akihiro ; Asano, Hiroyuki ; Murase, Yosuke ; Miyata, Seiko ; Nakatochi, Masahiro ; Ouchi, Noriyuki ; Ichihara, Sahoko ; Yasui, Kenji ; Yoshida, Tsutomu ; Naruse, Keiko ; Matsubara, Tatsuaki ; Yokota, Mitsuhiro. / Relation of a common variant of the adiponectin gene to serum adiponectin concentration and metabolic traits in an aged Japanese population. In: European Journal of Human Genetics. 2011 ; Vol. 19, No. 3. pp. 262-269.
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abstract = "Adiponectin is an adipocyte-derived protein that is down-regulated in obesity-linked disorders. Variants of the adiponectin gene (ADIPOQ) have been shown to affect adiponectin level. We have now examined the relation of polymorphisms of ADIPOQ to adiponectin concentration and to metabolic disorders in the Kita-Nagoya Genomic Epidemiology study, a population-based study of elderly Japanese. The genomic region including ADIPOQ was genotyped for 30 single nucleotide polymorphisms in 500 subjects of a screening population with the use of a fluorescence- or colorimetry-based allele-specific DNA primer-probe assay system. Four polymorphisms were then selected for genotyping in an additional 2797 subjects. Serum adiponectin level was negatively associated with metabolic abnormalities after adjustment for age and sex. The minor alleles of the rs1656930, Ile164Thr, and rs9882205 polymorphisms were associated with a low serum adiponectin level. Whereas the minor alleles of rs1656930 and rs9882205 were common (minor allele frequency of 6.2 and 38.5{\%}, respectively), that of Ile164Thr was rare (0.9{\%}). The minor allele of rs1656930 was positively associated with systolic blood pressure and the prevalence of hypertension. The association of rs1656930 with adiponectin level was replicated in an independent population. A subject with the 164Thr/Thr genotype had an extremely low serum adiponectin level (0.6 g/ml) and the phenotype of metabolic syndrome. Our results suggest that a common variant of ADIPOQ, the minor allele of rs1656930, is associated with hypoadiponectinemia and hypertension. Screening for a common genetic background underlying low adiponectin levels might provide important information for assessment and management of metabolic disorders.",
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Tanimura, D, Shibata, R, Izawa, H, Hirashiki, A, Asano, H, Murase, Y, Miyata, S, Nakatochi, M, Ouchi, N, Ichihara, S, Yasui, K, Yoshida, T, Naruse, K, Matsubara, T & Yokota, M 2011, 'Relation of a common variant of the adiponectin gene to serum adiponectin concentration and metabolic traits in an aged Japanese population', European Journal of Human Genetics, vol. 19, no. 3, pp. 262-269. https://doi.org/10.1038/ejhg.2010.201

Relation of a common variant of the adiponectin gene to serum adiponectin concentration and metabolic traits in an aged Japanese population. / Tanimura, Daisuke; Shibata, Rei; Izawa, Hideo; Hirashiki, Akihiro; Asano, Hiroyuki; Murase, Yosuke; Miyata, Seiko; Nakatochi, Masahiro; Ouchi, Noriyuki; Ichihara, Sahoko; Yasui, Kenji; Yoshida, Tsutomu; Naruse, Keiko; Matsubara, Tatsuaki; Yokota, Mitsuhiro.

In: European Journal of Human Genetics, Vol. 19, No. 3, 01.03.2011, p. 262-269.

Research output: Contribution to journalArticle

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T1 - Relation of a common variant of the adiponectin gene to serum adiponectin concentration and metabolic traits in an aged Japanese population

AU - Tanimura, Daisuke

AU - Shibata, Rei

AU - Izawa, Hideo

AU - Hirashiki, Akihiro

AU - Asano, Hiroyuki

AU - Murase, Yosuke

AU - Miyata, Seiko

AU - Nakatochi, Masahiro

AU - Ouchi, Noriyuki

AU - Ichihara, Sahoko

AU - Yasui, Kenji

AU - Yoshida, Tsutomu

AU - Naruse, Keiko

AU - Matsubara, Tatsuaki

AU - Yokota, Mitsuhiro

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N2 - Adiponectin is an adipocyte-derived protein that is down-regulated in obesity-linked disorders. Variants of the adiponectin gene (ADIPOQ) have been shown to affect adiponectin level. We have now examined the relation of polymorphisms of ADIPOQ to adiponectin concentration and to metabolic disorders in the Kita-Nagoya Genomic Epidemiology study, a population-based study of elderly Japanese. The genomic region including ADIPOQ was genotyped for 30 single nucleotide polymorphisms in 500 subjects of a screening population with the use of a fluorescence- or colorimetry-based allele-specific DNA primer-probe assay system. Four polymorphisms were then selected for genotyping in an additional 2797 subjects. Serum adiponectin level was negatively associated with metabolic abnormalities after adjustment for age and sex. The minor alleles of the rs1656930, Ile164Thr, and rs9882205 polymorphisms were associated with a low serum adiponectin level. Whereas the minor alleles of rs1656930 and rs9882205 were common (minor allele frequency of 6.2 and 38.5%, respectively), that of Ile164Thr was rare (0.9%). The minor allele of rs1656930 was positively associated with systolic blood pressure and the prevalence of hypertension. The association of rs1656930 with adiponectin level was replicated in an independent population. A subject with the 164Thr/Thr genotype had an extremely low serum adiponectin level (0.6 g/ml) and the phenotype of metabolic syndrome. Our results suggest that a common variant of ADIPOQ, the minor allele of rs1656930, is associated with hypoadiponectinemia and hypertension. Screening for a common genetic background underlying low adiponectin levels might provide important information for assessment and management of metabolic disorders.

AB - Adiponectin is an adipocyte-derived protein that is down-regulated in obesity-linked disorders. Variants of the adiponectin gene (ADIPOQ) have been shown to affect adiponectin level. We have now examined the relation of polymorphisms of ADIPOQ to adiponectin concentration and to metabolic disorders in the Kita-Nagoya Genomic Epidemiology study, a population-based study of elderly Japanese. The genomic region including ADIPOQ was genotyped for 30 single nucleotide polymorphisms in 500 subjects of a screening population with the use of a fluorescence- or colorimetry-based allele-specific DNA primer-probe assay system. Four polymorphisms were then selected for genotyping in an additional 2797 subjects. Serum adiponectin level was negatively associated with metabolic abnormalities after adjustment for age and sex. The minor alleles of the rs1656930, Ile164Thr, and rs9882205 polymorphisms were associated with a low serum adiponectin level. Whereas the minor alleles of rs1656930 and rs9882205 were common (minor allele frequency of 6.2 and 38.5%, respectively), that of Ile164Thr was rare (0.9%). The minor allele of rs1656930 was positively associated with systolic blood pressure and the prevalence of hypertension. The association of rs1656930 with adiponectin level was replicated in an independent population. A subject with the 164Thr/Thr genotype had an extremely low serum adiponectin level (0.6 g/ml) and the phenotype of metabolic syndrome. Our results suggest that a common variant of ADIPOQ, the minor allele of rs1656930, is associated with hypoadiponectinemia and hypertension. Screening for a common genetic background underlying low adiponectin levels might provide important information for assessment and management of metabolic disorders.

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