Relation of plasma catecholamine levels with pulse wave velocity in hypertensive patients compared with normotensive subjects

Kiyoyasu Yamada, Shigeo Iino, Satoshi Isobe, Takahisa Kondo, Hideo Izawa, Yasuya Inden, Mari Yoshikane, Nobuo Ikeda, Makoto Hirai, Ken Sawada, Toyoaki Murohara

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Although the circadian variation of catecholamine has been reported, that of the pulse wave velocity (PWV) has not. Brachial ankle (ba) PWV is associated with well-established indices of central stiffness. It is not known whether arterial stiffness is associated with catecholamine. The aim of the present study was to evaluate the changes in baPWV and those on the plasma epinephrine and norepinephrine levels in the morning and evening in hypertensive patients (HPs) and normotensive subjects (NSs). The baPWV and blood pressure (BP) were measured in 14 NSs (14 males, 39 ± 5 years) and 10 HPs (9 males and 1 female, 55 ± 13 years) at 06:00 h, noon, 18:00 h, and midnight, respectively. The plasma epinephrine and norepinephrine levels were measured in 14 NSs and 5 HPs at 06:00 h and 18:00 h, respectively. There was no significant difference in BPs at 06:00 h, noon, 18:00 h, and midnight in either NSs or HPs. The baPWV at 06:00 h was significantly lower than that at noon, 18:00 h, and midnight in NSs (P = 0.01, 0.04, and 0.0008, respectively). The plasma epinephrine and norepinephrine levels at 06:00 h were markedly lower than those at 18:00 h in NSs (P = 0.002 and 0.003, respectively). There were no significant changes in the baPWV of HPs at 06:00 h, noon, 18:00 h, or midnight. The plasma epinephrine and norepinephrine levels at 06:00 h were notably lower than those at 18:00 h in HPs (P = 0.004 and 0.01, respectively). Only NSs showed a significant reduction in the baPWV with a decrease in the plasma catecholamine levels in the morning, suggesting that the baPWV of NSs may be correlated with the variation of the plasma catecholamine levels.

Original languageEnglish
Pages (from-to)493-498
Number of pages6
JournalHeart and Vessels
Volume27
Issue number5
DOIs
Publication statusPublished - 01-09-2012
Externally publishedYes

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Pulse Wave Analysis
Catecholamines
Epinephrine
Norepinephrine
Vascular Stiffness
Ankle
Arm
Blood Pressure

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Yamada, Kiyoyasu ; Iino, Shigeo ; Isobe, Satoshi ; Kondo, Takahisa ; Izawa, Hideo ; Inden, Yasuya ; Yoshikane, Mari ; Ikeda, Nobuo ; Hirai, Makoto ; Sawada, Ken ; Murohara, Toyoaki. / Relation of plasma catecholamine levels with pulse wave velocity in hypertensive patients compared with normotensive subjects. In: Heart and Vessels. 2012 ; Vol. 27, No. 5. pp. 493-498.
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abstract = "Although the circadian variation of catecholamine has been reported, that of the pulse wave velocity (PWV) has not. Brachial ankle (ba) PWV is associated with well-established indices of central stiffness. It is not known whether arterial stiffness is associated with catecholamine. The aim of the present study was to evaluate the changes in baPWV and those on the plasma epinephrine and norepinephrine levels in the morning and evening in hypertensive patients (HPs) and normotensive subjects (NSs). The baPWV and blood pressure (BP) were measured in 14 NSs (14 males, 39 ± 5 years) and 10 HPs (9 males and 1 female, 55 ± 13 years) at 06:00 h, noon, 18:00 h, and midnight, respectively. The plasma epinephrine and norepinephrine levels were measured in 14 NSs and 5 HPs at 06:00 h and 18:00 h, respectively. There was no significant difference in BPs at 06:00 h, noon, 18:00 h, and midnight in either NSs or HPs. The baPWV at 06:00 h was significantly lower than that at noon, 18:00 h, and midnight in NSs (P = 0.01, 0.04, and 0.0008, respectively). The plasma epinephrine and norepinephrine levels at 06:00 h were markedly lower than those at 18:00 h in NSs (P = 0.002 and 0.003, respectively). There were no significant changes in the baPWV of HPs at 06:00 h, noon, 18:00 h, or midnight. The plasma epinephrine and norepinephrine levels at 06:00 h were notably lower than those at 18:00 h in HPs (P = 0.004 and 0.01, respectively). Only NSs showed a significant reduction in the baPWV with a decrease in the plasma catecholamine levels in the morning, suggesting that the baPWV of NSs may be correlated with the variation of the plasma catecholamine levels.",
author = "Kiyoyasu Yamada and Shigeo Iino and Satoshi Isobe and Takahisa Kondo and Hideo Izawa and Yasuya Inden and Mari Yoshikane and Nobuo Ikeda and Makoto Hirai and Ken Sawada and Toyoaki Murohara",
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Yamada, K, Iino, S, Isobe, S, Kondo, T, Izawa, H, Inden, Y, Yoshikane, M, Ikeda, N, Hirai, M, Sawada, K & Murohara, T 2012, 'Relation of plasma catecholamine levels with pulse wave velocity in hypertensive patients compared with normotensive subjects', Heart and Vessels, vol. 27, no. 5, pp. 493-498. https://doi.org/10.1007/s00380-011-0174-9

Relation of plasma catecholamine levels with pulse wave velocity in hypertensive patients compared with normotensive subjects. / Yamada, Kiyoyasu; Iino, Shigeo; Isobe, Satoshi; Kondo, Takahisa; Izawa, Hideo; Inden, Yasuya; Yoshikane, Mari; Ikeda, Nobuo; Hirai, Makoto; Sawada, Ken; Murohara, Toyoaki.

In: Heart and Vessels, Vol. 27, No. 5, 01.09.2012, p. 493-498.

Research output: Contribution to journalArticle

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T1 - Relation of plasma catecholamine levels with pulse wave velocity in hypertensive patients compared with normotensive subjects

AU - Yamada, Kiyoyasu

AU - Iino, Shigeo

AU - Isobe, Satoshi

AU - Kondo, Takahisa

AU - Izawa, Hideo

AU - Inden, Yasuya

AU - Yoshikane, Mari

AU - Ikeda, Nobuo

AU - Hirai, Makoto

AU - Sawada, Ken

AU - Murohara, Toyoaki

PY - 2012/9/1

Y1 - 2012/9/1

N2 - Although the circadian variation of catecholamine has been reported, that of the pulse wave velocity (PWV) has not. Brachial ankle (ba) PWV is associated with well-established indices of central stiffness. It is not known whether arterial stiffness is associated with catecholamine. The aim of the present study was to evaluate the changes in baPWV and those on the plasma epinephrine and norepinephrine levels in the morning and evening in hypertensive patients (HPs) and normotensive subjects (NSs). The baPWV and blood pressure (BP) were measured in 14 NSs (14 males, 39 ± 5 years) and 10 HPs (9 males and 1 female, 55 ± 13 years) at 06:00 h, noon, 18:00 h, and midnight, respectively. The plasma epinephrine and norepinephrine levels were measured in 14 NSs and 5 HPs at 06:00 h and 18:00 h, respectively. There was no significant difference in BPs at 06:00 h, noon, 18:00 h, and midnight in either NSs or HPs. The baPWV at 06:00 h was significantly lower than that at noon, 18:00 h, and midnight in NSs (P = 0.01, 0.04, and 0.0008, respectively). The plasma epinephrine and norepinephrine levels at 06:00 h were markedly lower than those at 18:00 h in NSs (P = 0.002 and 0.003, respectively). There were no significant changes in the baPWV of HPs at 06:00 h, noon, 18:00 h, or midnight. The plasma epinephrine and norepinephrine levels at 06:00 h were notably lower than those at 18:00 h in HPs (P = 0.004 and 0.01, respectively). Only NSs showed a significant reduction in the baPWV with a decrease in the plasma catecholamine levels in the morning, suggesting that the baPWV of NSs may be correlated with the variation of the plasma catecholamine levels.

AB - Although the circadian variation of catecholamine has been reported, that of the pulse wave velocity (PWV) has not. Brachial ankle (ba) PWV is associated with well-established indices of central stiffness. It is not known whether arterial stiffness is associated with catecholamine. The aim of the present study was to evaluate the changes in baPWV and those on the plasma epinephrine and norepinephrine levels in the morning and evening in hypertensive patients (HPs) and normotensive subjects (NSs). The baPWV and blood pressure (BP) were measured in 14 NSs (14 males, 39 ± 5 years) and 10 HPs (9 males and 1 female, 55 ± 13 years) at 06:00 h, noon, 18:00 h, and midnight, respectively. The plasma epinephrine and norepinephrine levels were measured in 14 NSs and 5 HPs at 06:00 h and 18:00 h, respectively. There was no significant difference in BPs at 06:00 h, noon, 18:00 h, and midnight in either NSs or HPs. The baPWV at 06:00 h was significantly lower than that at noon, 18:00 h, and midnight in NSs (P = 0.01, 0.04, and 0.0008, respectively). The plasma epinephrine and norepinephrine levels at 06:00 h were markedly lower than those at 18:00 h in NSs (P = 0.002 and 0.003, respectively). There were no significant changes in the baPWV of HPs at 06:00 h, noon, 18:00 h, or midnight. The plasma epinephrine and norepinephrine levels at 06:00 h were notably lower than those at 18:00 h in HPs (P = 0.004 and 0.01, respectively). Only NSs showed a significant reduction in the baPWV with a decrease in the plasma catecholamine levels in the morning, suggesting that the baPWV of NSs may be correlated with the variation of the plasma catecholamine levels.

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