Relationship between a BDNF gene polymorphism and the brain volume in treatment-naive patients with major depressive disorder: A VBM analysis of brain MRI

Satoru Ide, Shingo Kakeda, Keita Watanabe, Reiji Yoshimura, Osamu Abe, Kenji Hayashi, Issei Ueda, Taro Kishi, Asuka Katsuki, Wakako Umene-Nakano, Nakao Iwata, Jun Nakamura, Yukunori Korogi

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The brain-derived neurotrophic factor (BDNF) relates to basic neuronal functions, such as cell survival, axonal outgrowth, and dendritic growth. The Val66Met polymorphism of the BDNF gene may affect genetic susceptibility to major depressive disorder (MDD). We prospectively investigated the relationship between the Val66Met BDNF genotype and voxel-based morphometry (VBM) findings for first episode and drug-naïve MDD patients and healthy subjects (HS). Participants comprised 38 MDD patients and 42 age- and sex-matched HS were divided into groups based on their BDNF genotype. The effects of diagnosis and genotype, as well as the genotype-diagnosis interaction, in relation to brain morphology were evaluated using a voxel-by-voxel statistical analysis of high-resolution magnetic resonance imaging (MRI) findings. Among the Met-carriers, the volume of the left middle frontal gyrus (composition of the prefrontal cortex [PFC]) was significantly smaller for MDD patients than for the HS, i.e., there was a significant genotype-diagnosis interaction effect on brain morphology noted in the left PFC. The BDNF polymorphism was associated with atrophy of the PFC in MDD patients, which suggests that the BDNF Val66Met polymorphism may play an important role in the pathogenesis of early stages of MDD.

Original languageEnglish
Pages (from-to)120-124
Number of pages5
JournalPsychiatry Research - Neuroimaging
Volume233
Issue number2
DOIs
Publication statusPublished - 30-08-2015

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Brain-Derived Neurotrophic Factor
Major Depressive Disorder
Magnetic Resonance Imaging
Genotype
Brain
Prefrontal Cortex
Genes
Healthy Volunteers
Therapeutics
Genetic Predisposition to Disease
Atrophy
Cell Survival
Growth
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Neuroscience (miscellaneous)
  • Radiology Nuclear Medicine and imaging
  • Psychiatry and Mental health

Cite this

Ide, Satoru ; Kakeda, Shingo ; Watanabe, Keita ; Yoshimura, Reiji ; Abe, Osamu ; Hayashi, Kenji ; Ueda, Issei ; Kishi, Taro ; Katsuki, Asuka ; Umene-Nakano, Wakako ; Iwata, Nakao ; Nakamura, Jun ; Korogi, Yukunori. / Relationship between a BDNF gene polymorphism and the brain volume in treatment-naive patients with major depressive disorder : A VBM analysis of brain MRI. In: Psychiatry Research - Neuroimaging. 2015 ; Vol. 233, No. 2. pp. 120-124.
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abstract = "The brain-derived neurotrophic factor (BDNF) relates to basic neuronal functions, such as cell survival, axonal outgrowth, and dendritic growth. The Val66Met polymorphism of the BDNF gene may affect genetic susceptibility to major depressive disorder (MDD). We prospectively investigated the relationship between the Val66Met BDNF genotype and voxel-based morphometry (VBM) findings for first episode and drug-na{\"i}ve MDD patients and healthy subjects (HS). Participants comprised 38 MDD patients and 42 age- and sex-matched HS were divided into groups based on their BDNF genotype. The effects of diagnosis and genotype, as well as the genotype-diagnosis interaction, in relation to brain morphology were evaluated using a voxel-by-voxel statistical analysis of high-resolution magnetic resonance imaging (MRI) findings. Among the Met-carriers, the volume of the left middle frontal gyrus (composition of the prefrontal cortex [PFC]) was significantly smaller for MDD patients than for the HS, i.e., there was a significant genotype-diagnosis interaction effect on brain morphology noted in the left PFC. The BDNF polymorphism was associated with atrophy of the PFC in MDD patients, which suggests that the BDNF Val66Met polymorphism may play an important role in the pathogenesis of early stages of MDD.",
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Ide, S, Kakeda, S, Watanabe, K, Yoshimura, R, Abe, O, Hayashi, K, Ueda, I, Kishi, T, Katsuki, A, Umene-Nakano, W, Iwata, N, Nakamura, J & Korogi, Y 2015, 'Relationship between a BDNF gene polymorphism and the brain volume in treatment-naive patients with major depressive disorder: A VBM analysis of brain MRI', Psychiatry Research - Neuroimaging, vol. 233, no. 2, pp. 120-124. https://doi.org/10.1016/j.pscychresns.2015.05.016

Relationship between a BDNF gene polymorphism and the brain volume in treatment-naive patients with major depressive disorder : A VBM analysis of brain MRI. / Ide, Satoru; Kakeda, Shingo; Watanabe, Keita; Yoshimura, Reiji; Abe, Osamu; Hayashi, Kenji; Ueda, Issei; Kishi, Taro; Katsuki, Asuka; Umene-Nakano, Wakako; Iwata, Nakao; Nakamura, Jun; Korogi, Yukunori.

In: Psychiatry Research - Neuroimaging, Vol. 233, No. 2, 30.08.2015, p. 120-124.

Research output: Contribution to journalArticle

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T1 - Relationship between a BDNF gene polymorphism and the brain volume in treatment-naive patients with major depressive disorder

T2 - A VBM analysis of brain MRI

AU - Ide, Satoru

AU - Kakeda, Shingo

AU - Watanabe, Keita

AU - Yoshimura, Reiji

AU - Abe, Osamu

AU - Hayashi, Kenji

AU - Ueda, Issei

AU - Kishi, Taro

AU - Katsuki, Asuka

AU - Umene-Nakano, Wakako

AU - Iwata, Nakao

AU - Nakamura, Jun

AU - Korogi, Yukunori

PY - 2015/8/30

Y1 - 2015/8/30

N2 - The brain-derived neurotrophic factor (BDNF) relates to basic neuronal functions, such as cell survival, axonal outgrowth, and dendritic growth. The Val66Met polymorphism of the BDNF gene may affect genetic susceptibility to major depressive disorder (MDD). We prospectively investigated the relationship between the Val66Met BDNF genotype and voxel-based morphometry (VBM) findings for first episode and drug-naïve MDD patients and healthy subjects (HS). Participants comprised 38 MDD patients and 42 age- and sex-matched HS were divided into groups based on their BDNF genotype. The effects of diagnosis and genotype, as well as the genotype-diagnosis interaction, in relation to brain morphology were evaluated using a voxel-by-voxel statistical analysis of high-resolution magnetic resonance imaging (MRI) findings. Among the Met-carriers, the volume of the left middle frontal gyrus (composition of the prefrontal cortex [PFC]) was significantly smaller for MDD patients than for the HS, i.e., there was a significant genotype-diagnosis interaction effect on brain morphology noted in the left PFC. The BDNF polymorphism was associated with atrophy of the PFC in MDD patients, which suggests that the BDNF Val66Met polymorphism may play an important role in the pathogenesis of early stages of MDD.

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