Relationship between anti-aversive effects of salmon calcitonin and plasma levels of ACTH, beta-endorphin and prostaglandin E 2 in mice

Y. Maeda, K. Yamada, T. Hasegawa, Y. Kawamata, K. Uchida, M. Iyo, S. Fukui, Toshitaka Nabeshima

Research output: Contribution to journalArticle

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Abstract

We investigated whether the anti-aversive effects of salmon calcitonin (SCT) was induced by increasing ACTH and beta-endorphin and/or by decreasing of prostaglandin E 2 (PGE 2 ) levels in plasma of mice to elucidate the mechanisms responsible for the analgesic effects of SCT. Intracerebroventricular (i.c.v.) injections of SCT inhibited acetic acid- induced aversive behavior (writhing) in a U-shaped dose response curve, the most effective dose being 0.1 IU/mouse. Intraperitoneal (i.p.) injections of acetic acid increased, but not significantly, the levels of plasma ACTH and PGE 2 , but not beta-endorphin, which are considered to be psychoneuroendocrines correlated with pain. SCT (0.1 IU/mouse, i.c.v.) significantly increased plasma ACTH levels (p<0.05) and tended to increase beta-endorphin levels (p=0.052) in acetic acid-treated mice, whereas no change in PGE 2 level was observed (p>0.1). These results suggest that the anti-aversive effects of SCT may be mediated, at least in part, by the activation of ACTH.

Original languageEnglish
Pages (from-to)15-24
Number of pages10
JournalResearch Communications in Chemical Pathology and Pharmacology
Volume83
Issue number1
Publication statusPublished - 01-01-1994
Externally publishedYes

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salmon calcitonin
beta-Endorphin
Prostaglandins E
Adrenocorticotropic Hormone
Plasmas
Acetic Acid
Intraperitoneal Injections
Analgesics
Chemical activation
Pain
Injections

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Toxicology
  • Pharmacology
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

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title = "Relationship between anti-aversive effects of salmon calcitonin and plasma levels of ACTH, beta-endorphin and prostaglandin E 2 in mice",
abstract = "We investigated whether the anti-aversive effects of salmon calcitonin (SCT) was induced by increasing ACTH and beta-endorphin and/or by decreasing of prostaglandin E 2 (PGE 2 ) levels in plasma of mice to elucidate the mechanisms responsible for the analgesic effects of SCT. Intracerebroventricular (i.c.v.) injections of SCT inhibited acetic acid- induced aversive behavior (writhing) in a U-shaped dose response curve, the most effective dose being 0.1 IU/mouse. Intraperitoneal (i.p.) injections of acetic acid increased, but not significantly, the levels of plasma ACTH and PGE 2 , but not beta-endorphin, which are considered to be psychoneuroendocrines correlated with pain. SCT (0.1 IU/mouse, i.c.v.) significantly increased plasma ACTH levels (p<0.05) and tended to increase beta-endorphin levels (p=0.052) in acetic acid-treated mice, whereas no change in PGE 2 level was observed (p>0.1). These results suggest that the anti-aversive effects of SCT may be mediated, at least in part, by the activation of ACTH.",
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Relationship between anti-aversive effects of salmon calcitonin and plasma levels of ACTH, beta-endorphin and prostaglandin E 2 in mice . / Maeda, Y.; Yamada, K.; Hasegawa, T.; Kawamata, Y.; Uchida, K.; Iyo, M.; Fukui, S.; Nabeshima, Toshitaka.

In: Research Communications in Chemical Pathology and Pharmacology, Vol. 83, No. 1, 01.01.1994, p. 15-24.

Research output: Contribution to journalArticle

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AU - Maeda, Y.

AU - Yamada, K.

AU - Hasegawa, T.

AU - Kawamata, Y.

AU - Uchida, K.

AU - Iyo, M.

AU - Fukui, S.

AU - Nabeshima, Toshitaka

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N2 - We investigated whether the anti-aversive effects of salmon calcitonin (SCT) was induced by increasing ACTH and beta-endorphin and/or by decreasing of prostaglandin E 2 (PGE 2 ) levels in plasma of mice to elucidate the mechanisms responsible for the analgesic effects of SCT. Intracerebroventricular (i.c.v.) injections of SCT inhibited acetic acid- induced aversive behavior (writhing) in a U-shaped dose response curve, the most effective dose being 0.1 IU/mouse. Intraperitoneal (i.p.) injections of acetic acid increased, but not significantly, the levels of plasma ACTH and PGE 2 , but not beta-endorphin, which are considered to be psychoneuroendocrines correlated with pain. SCT (0.1 IU/mouse, i.c.v.) significantly increased plasma ACTH levels (p<0.05) and tended to increase beta-endorphin levels (p=0.052) in acetic acid-treated mice, whereas no change in PGE 2 level was observed (p>0.1). These results suggest that the anti-aversive effects of SCT may be mediated, at least in part, by the activation of ACTH.

AB - We investigated whether the anti-aversive effects of salmon calcitonin (SCT) was induced by increasing ACTH and beta-endorphin and/or by decreasing of prostaglandin E 2 (PGE 2 ) levels in plasma of mice to elucidate the mechanisms responsible for the analgesic effects of SCT. Intracerebroventricular (i.c.v.) injections of SCT inhibited acetic acid- induced aversive behavior (writhing) in a U-shaped dose response curve, the most effective dose being 0.1 IU/mouse. Intraperitoneal (i.p.) injections of acetic acid increased, but not significantly, the levels of plasma ACTH and PGE 2 , but not beta-endorphin, which are considered to be psychoneuroendocrines correlated with pain. SCT (0.1 IU/mouse, i.c.v.) significantly increased plasma ACTH levels (p<0.05) and tended to increase beta-endorphin levels (p=0.052) in acetic acid-treated mice, whereas no change in PGE 2 level was observed (p>0.1). These results suggest that the anti-aversive effects of SCT may be mediated, at least in part, by the activation of ACTH.

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