Relationship between BNP level and renal function in diabetic nephropathy with microalbuminuria

Naoto Seki, Motonobu Nishimura, Tsuyoshi Matsumoto, Motoharu Fukazawa, Takashi Kenmochi

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Aims: We examined the relationship between the brain natriuretic peptide (BNP) level and renal function in diabetic nephropathy with microalbuminuria. Methods: The subjects were 97 Japanese type 2 diabetes mellitus outpatients with microalbuminuria. Associations between the annual rate of decline in estimated glomerular filtration rate (eGFR) and various metabolic parameters at baseline (BMI, systolic blood pressure, HbA1c, LDL cholesterol, urine albumin-creatinine ratio, BNP and eGFR) were examined. Results: Among the baseline factors, eGFR and BNP had significant associations with the annual rate of decline in eGFR in Pearson correlation analysis (r = 0.295, p = 0.003; r = 0.223, p = 0.028, respectively). Multiple linear regression analysis also showed the significance of baseline eGFR and BNP as independent predictors of renal function (β = 0.340, p = 0.001; β = 0.278, p = 0.005, respectively). In multivariate logistic regression analysis, eGFR and BNP were independently associated with the risk of a decline in GFR (p = 0.003, p = 0.011, respectively). ROC curve analysis showed a cutoff value of BNP is 17.0 pg/mL for predicting a decline in GFR. Conclusions: The BNP level at baseline is an independent predictor of the annual rate of decline in eGFR. Therefore, monitoring of BNP can play an important role in management of diabetic nephropathy.

Original languageEnglish
Pages (from-to)92-97
Number of pages6
JournalJournal of Diabetes and its Complications
Volume27
Issue number1
DOIs
Publication statusPublished - 01-01-2013

Fingerprint

Brain Natriuretic Peptide
Diabetic Nephropathies
Glomerular Filtration Rate
Kidney
ROC Curve
Regression Analysis
Blood Pressure
LDL Cholesterol
Type 2 Diabetes Mellitus
Albumins
Linear Models
Creatinine
Outpatients
Logistic Models
Urine

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Seki, Naoto ; Nishimura, Motonobu ; Matsumoto, Tsuyoshi ; Fukazawa, Motoharu ; Kenmochi, Takashi. / Relationship between BNP level and renal function in diabetic nephropathy with microalbuminuria. In: Journal of Diabetes and its Complications. 2013 ; Vol. 27, No. 1. pp. 92-97.
@article{ccd6c2377c2d4c6aadb87455425dba81,
title = "Relationship between BNP level and renal function in diabetic nephropathy with microalbuminuria",
abstract = "Aims: We examined the relationship between the brain natriuretic peptide (BNP) level and renal function in diabetic nephropathy with microalbuminuria. Methods: The subjects were 97 Japanese type 2 diabetes mellitus outpatients with microalbuminuria. Associations between the annual rate of decline in estimated glomerular filtration rate (eGFR) and various metabolic parameters at baseline (BMI, systolic blood pressure, HbA1c, LDL cholesterol, urine albumin-creatinine ratio, BNP and eGFR) were examined. Results: Among the baseline factors, eGFR and BNP had significant associations with the annual rate of decline in eGFR in Pearson correlation analysis (r = 0.295, p = 0.003; r = 0.223, p = 0.028, respectively). Multiple linear regression analysis also showed the significance of baseline eGFR and BNP as independent predictors of renal function (β = 0.340, p = 0.001; β = 0.278, p = 0.005, respectively). In multivariate logistic regression analysis, eGFR and BNP were independently associated with the risk of a decline in GFR (p = 0.003, p = 0.011, respectively). ROC curve analysis showed a cutoff value of BNP is 17.0 pg/mL for predicting a decline in GFR. Conclusions: The BNP level at baseline is an independent predictor of the annual rate of decline in eGFR. Therefore, monitoring of BNP can play an important role in management of diabetic nephropathy.",
author = "Naoto Seki and Motonobu Nishimura and Tsuyoshi Matsumoto and Motoharu Fukazawa and Takashi Kenmochi",
year = "2013",
month = "1",
day = "1",
doi = "10.1016/j.jdiacomp.2012.06.013",
language = "English",
volume = "27",
pages = "92--97",
journal = "Journal of Diabetes and its Complications",
issn = "1056-8727",
publisher = "Elsevier Inc.",
number = "1",

}

Relationship between BNP level and renal function in diabetic nephropathy with microalbuminuria. / Seki, Naoto; Nishimura, Motonobu; Matsumoto, Tsuyoshi; Fukazawa, Motoharu; Kenmochi, Takashi.

In: Journal of Diabetes and its Complications, Vol. 27, No. 1, 01.01.2013, p. 92-97.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Relationship between BNP level and renal function in diabetic nephropathy with microalbuminuria

AU - Seki, Naoto

AU - Nishimura, Motonobu

AU - Matsumoto, Tsuyoshi

AU - Fukazawa, Motoharu

AU - Kenmochi, Takashi

PY - 2013/1/1

Y1 - 2013/1/1

N2 - Aims: We examined the relationship between the brain natriuretic peptide (BNP) level and renal function in diabetic nephropathy with microalbuminuria. Methods: The subjects were 97 Japanese type 2 diabetes mellitus outpatients with microalbuminuria. Associations between the annual rate of decline in estimated glomerular filtration rate (eGFR) and various metabolic parameters at baseline (BMI, systolic blood pressure, HbA1c, LDL cholesterol, urine albumin-creatinine ratio, BNP and eGFR) were examined. Results: Among the baseline factors, eGFR and BNP had significant associations with the annual rate of decline in eGFR in Pearson correlation analysis (r = 0.295, p = 0.003; r = 0.223, p = 0.028, respectively). Multiple linear regression analysis also showed the significance of baseline eGFR and BNP as independent predictors of renal function (β = 0.340, p = 0.001; β = 0.278, p = 0.005, respectively). In multivariate logistic regression analysis, eGFR and BNP were independently associated with the risk of a decline in GFR (p = 0.003, p = 0.011, respectively). ROC curve analysis showed a cutoff value of BNP is 17.0 pg/mL for predicting a decline in GFR. Conclusions: The BNP level at baseline is an independent predictor of the annual rate of decline in eGFR. Therefore, monitoring of BNP can play an important role in management of diabetic nephropathy.

AB - Aims: We examined the relationship between the brain natriuretic peptide (BNP) level and renal function in diabetic nephropathy with microalbuminuria. Methods: The subjects were 97 Japanese type 2 diabetes mellitus outpatients with microalbuminuria. Associations between the annual rate of decline in estimated glomerular filtration rate (eGFR) and various metabolic parameters at baseline (BMI, systolic blood pressure, HbA1c, LDL cholesterol, urine albumin-creatinine ratio, BNP and eGFR) were examined. Results: Among the baseline factors, eGFR and BNP had significant associations with the annual rate of decline in eGFR in Pearson correlation analysis (r = 0.295, p = 0.003; r = 0.223, p = 0.028, respectively). Multiple linear regression analysis also showed the significance of baseline eGFR and BNP as independent predictors of renal function (β = 0.340, p = 0.001; β = 0.278, p = 0.005, respectively). In multivariate logistic regression analysis, eGFR and BNP were independently associated with the risk of a decline in GFR (p = 0.003, p = 0.011, respectively). ROC curve analysis showed a cutoff value of BNP is 17.0 pg/mL for predicting a decline in GFR. Conclusions: The BNP level at baseline is an independent predictor of the annual rate of decline in eGFR. Therefore, monitoring of BNP can play an important role in management of diabetic nephropathy.

UR - http://www.scopus.com/inward/record.url?scp=84872490869&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84872490869&partnerID=8YFLogxK

U2 - 10.1016/j.jdiacomp.2012.06.013

DO - 10.1016/j.jdiacomp.2012.06.013

M3 - Article

VL - 27

SP - 92

EP - 97

JO - Journal of Diabetes and its Complications

JF - Journal of Diabetes and its Complications

SN - 1056-8727

IS - 1

ER -