Relationship between body mass index and the risk of ovarian cancer in the Japanese population: Findings from the Japanese Collaborate Cohort (JACC) study

Yoshimitsu Niwa, Hiroshi Yatsuya, Koji Tamakoshi, Kazuko Nishio, Takaaki Kondo, Yingsong Lin, Sadao Suzuki, Kenji Wakai, Shinkan Tokudome, Akio Yamamoto, Nobuyuki Hamajima, Hideaki Toyoshima, Akiko Tamakoshi

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Aim: The incidence of ovarian cancer in Japan has increased since the 1970s. The many studies that have assessed the relationship between body mass index (BMI) and the risk of ovarian cancer have produced contradictory results. Here we investigated this relation using data from the Japan Collaborative Cohort Study for the Evaluation of Cancer Risk, which was initiated in 1988. Methods: A self-administered questionnaire on dietary habits and other risk factors for cancer was completed by 36 456 Japanese women. After 7.6 years of follow up, 38 cases of ovarian cancer were available for analysis. Cox proportional-hazards models were used to compute relative risks and to adjust for confounders. Results: Compared to women with BMI of 18.5-24.9 kg/m 2, the relative risk of ovarian cancer was 2.24 (95% CI = 1.10-4.21) for BMI of 25.0-29.9 and 1.78 (95% CI = 0.24-13.34) for BMI of ≥30 kg/m 2. A test for trend revealed that this finding was statistically significant (P = 0.014). Conclusion: The results of this study suggest that being overweight is independently associated with a higher risk of developing ovarian cancer in the Japanese population.

Original languageEnglish
Pages (from-to)452-458
Number of pages7
JournalJournal of Obstetrics and Gynaecology Research
Volume31
Issue number5
DOIs
Publication statusPublished - 01-10-2005
Externally publishedYes

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Ovarian Neoplasms
Body Mass Index
Cohort Studies
Population
Japan
Feeding Behavior
Proportional Hazards Models
Neoplasms
Incidence

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynaecology

Cite this

Niwa, Yoshimitsu ; Yatsuya, Hiroshi ; Tamakoshi, Koji ; Nishio, Kazuko ; Kondo, Takaaki ; Lin, Yingsong ; Suzuki, Sadao ; Wakai, Kenji ; Tokudome, Shinkan ; Yamamoto, Akio ; Hamajima, Nobuyuki ; Toyoshima, Hideaki ; Tamakoshi, Akiko. / Relationship between body mass index and the risk of ovarian cancer in the Japanese population : Findings from the Japanese Collaborate Cohort (JACC) study. In: Journal of Obstetrics and Gynaecology Research. 2005 ; Vol. 31, No. 5. pp. 452-458.
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abstract = "Aim: The incidence of ovarian cancer in Japan has increased since the 1970s. The many studies that have assessed the relationship between body mass index (BMI) and the risk of ovarian cancer have produced contradictory results. Here we investigated this relation using data from the Japan Collaborative Cohort Study for the Evaluation of Cancer Risk, which was initiated in 1988. Methods: A self-administered questionnaire on dietary habits and other risk factors for cancer was completed by 36 456 Japanese women. After 7.6 years of follow up, 38 cases of ovarian cancer were available for analysis. Cox proportional-hazards models were used to compute relative risks and to adjust for confounders. Results: Compared to women with BMI of 18.5-24.9 kg/m 2, the relative risk of ovarian cancer was 2.24 (95{\%} CI = 1.10-4.21) for BMI of 25.0-29.9 and 1.78 (95{\%} CI = 0.24-13.34) for BMI of ≥30 kg/m 2. A test for trend revealed that this finding was statistically significant (P = 0.014). Conclusion: The results of this study suggest that being overweight is independently associated with a higher risk of developing ovarian cancer in the Japanese population.",
author = "Yoshimitsu Niwa and Hiroshi Yatsuya and Koji Tamakoshi and Kazuko Nishio and Takaaki Kondo and Yingsong Lin and Sadao Suzuki and Kenji Wakai and Shinkan Tokudome and Akio Yamamoto and Nobuyuki Hamajima and Hideaki Toyoshima and Akiko Tamakoshi",
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Niwa, Y, Yatsuya, H, Tamakoshi, K, Nishio, K, Kondo, T, Lin, Y, Suzuki, S, Wakai, K, Tokudome, S, Yamamoto, A, Hamajima, N, Toyoshima, H & Tamakoshi, A 2005, 'Relationship between body mass index and the risk of ovarian cancer in the Japanese population: Findings from the Japanese Collaborate Cohort (JACC) study', Journal of Obstetrics and Gynaecology Research, vol. 31, no. 5, pp. 452-458. https://doi.org/10.1111/j.1447-0756.2005.00319.x

Relationship between body mass index and the risk of ovarian cancer in the Japanese population : Findings from the Japanese Collaborate Cohort (JACC) study. / Niwa, Yoshimitsu; Yatsuya, Hiroshi; Tamakoshi, Koji; Nishio, Kazuko; Kondo, Takaaki; Lin, Yingsong; Suzuki, Sadao; Wakai, Kenji; Tokudome, Shinkan; Yamamoto, Akio; Hamajima, Nobuyuki; Toyoshima, Hideaki; Tamakoshi, Akiko.

In: Journal of Obstetrics and Gynaecology Research, Vol. 31, No. 5, 01.10.2005, p. 452-458.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Relationship between body mass index and the risk of ovarian cancer in the Japanese population

T2 - Findings from the Japanese Collaborate Cohort (JACC) study

AU - Niwa, Yoshimitsu

AU - Yatsuya, Hiroshi

AU - Tamakoshi, Koji

AU - Nishio, Kazuko

AU - Kondo, Takaaki

AU - Lin, Yingsong

AU - Suzuki, Sadao

AU - Wakai, Kenji

AU - Tokudome, Shinkan

AU - Yamamoto, Akio

AU - Hamajima, Nobuyuki

AU - Toyoshima, Hideaki

AU - Tamakoshi, Akiko

PY - 2005/10/1

Y1 - 2005/10/1

N2 - Aim: The incidence of ovarian cancer in Japan has increased since the 1970s. The many studies that have assessed the relationship between body mass index (BMI) and the risk of ovarian cancer have produced contradictory results. Here we investigated this relation using data from the Japan Collaborative Cohort Study for the Evaluation of Cancer Risk, which was initiated in 1988. Methods: A self-administered questionnaire on dietary habits and other risk factors for cancer was completed by 36 456 Japanese women. After 7.6 years of follow up, 38 cases of ovarian cancer were available for analysis. Cox proportional-hazards models were used to compute relative risks and to adjust for confounders. Results: Compared to women with BMI of 18.5-24.9 kg/m 2, the relative risk of ovarian cancer was 2.24 (95% CI = 1.10-4.21) for BMI of 25.0-29.9 and 1.78 (95% CI = 0.24-13.34) for BMI of ≥30 kg/m 2. A test for trend revealed that this finding was statistically significant (P = 0.014). Conclusion: The results of this study suggest that being overweight is independently associated with a higher risk of developing ovarian cancer in the Japanese population.

AB - Aim: The incidence of ovarian cancer in Japan has increased since the 1970s. The many studies that have assessed the relationship between body mass index (BMI) and the risk of ovarian cancer have produced contradictory results. Here we investigated this relation using data from the Japan Collaborative Cohort Study for the Evaluation of Cancer Risk, which was initiated in 1988. Methods: A self-administered questionnaire on dietary habits and other risk factors for cancer was completed by 36 456 Japanese women. After 7.6 years of follow up, 38 cases of ovarian cancer were available for analysis. Cox proportional-hazards models were used to compute relative risks and to adjust for confounders. Results: Compared to women with BMI of 18.5-24.9 kg/m 2, the relative risk of ovarian cancer was 2.24 (95% CI = 1.10-4.21) for BMI of 25.0-29.9 and 1.78 (95% CI = 0.24-13.34) for BMI of ≥30 kg/m 2. A test for trend revealed that this finding was statistically significant (P = 0.014). Conclusion: The results of this study suggest that being overweight is independently associated with a higher risk of developing ovarian cancer in the Japanese population.

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