Relationship between electrocardiographic abnormalities and periodontal disease: The Hisayama study

Yoshihiro Shimazaki, Toshiyuki Saito, Yutaka Kiyohara, Isao Kato, Michiaki Kubo, Mitsuo Iida, Toshihiko Koga

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30 Citations (Scopus)

Abstract

Background: Recent studies have suggested a relationship between periodontitis and cardiovascular disease (CVD). This study investigated the relationship between periodontitis and electrocardiographic (ECG) abnormalities, which are known predictors of CVD. Methods: We examined the periodontal status of 1,111 residents of Hisayama Town, Fukuoka, Japan. Nine hundred fifty-seven (957) subjects (374 males, 583 females) with ≥10 teeth and without a medical history of CVD were included in the analysis. Probing depth (PD) and clinical attachment level (CAL) were measured on two randomly selected quadrants, one maxillary and one mandibular. A 12-lead ECG was recorded using a standard electrocardiograph. ECG abnormalities included left ventricular hypertrophy (Minnesota code 3-1) and ST depression (4-1, 2, 3). The relation of periodontal condition and ECG abnormalities was assessed with logistic regression analysis. Results: Univariate analysis revealed that mean probing depth, mean attachment loss, number of teeth, and plaque index were significantly associated with ECG abnormalities, as well as with known risk factors of CVD. In multivariate analysis, the subjects with deep pockets (mean probing depth ≥2 mm) had an increased risk for ECG abnormalities (odds ratio [OR] = 1.6; 95% confidence interval [CI] = 1.01 to 2.50) compared to the subjects with mean PD <2 mm. Subjects with severe attachment loss (mean CAL ≥2.5 mm) had also significant risk for ECG abnormalities (OR = 1.7; 95% CI = 1.07 to 2.67) compared to those whose mean CAL was <2.5 mm. Conclusion: This study clearly shows the relationship between periodontitis and ECG abnormalities, which are important predictors of CVD.

Original languageEnglish
Pages (from-to)791-797
Number of pages7
JournalJournal of Periodontology
Volume75
Issue number6
DOIs
Publication statusPublished - 01-06-2004

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Periodontal Diseases
Cardiovascular Diseases
Periodontitis
Odds Ratio
Confidence Intervals
Tooth Loss
Left Ventricular Hypertrophy
Tooth
Japan
Electrocardiography
Multivariate Analysis
Logistic Models
Regression Analysis

All Science Journal Classification (ASJC) codes

  • Periodontics

Cite this

Shimazaki, Yoshihiro ; Saito, Toshiyuki ; Kiyohara, Yutaka ; Kato, Isao ; Kubo, Michiaki ; Iida, Mitsuo ; Koga, Toshihiko. / Relationship between electrocardiographic abnormalities and periodontal disease : The Hisayama study. In: Journal of Periodontology. 2004 ; Vol. 75, No. 6. pp. 791-797.
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abstract = "Background: Recent studies have suggested a relationship between periodontitis and cardiovascular disease (CVD). This study investigated the relationship between periodontitis and electrocardiographic (ECG) abnormalities, which are known predictors of CVD. Methods: We examined the periodontal status of 1,111 residents of Hisayama Town, Fukuoka, Japan. Nine hundred fifty-seven (957) subjects (374 males, 583 females) with ≥10 teeth and without a medical history of CVD were included in the analysis. Probing depth (PD) and clinical attachment level (CAL) were measured on two randomly selected quadrants, one maxillary and one mandibular. A 12-lead ECG was recorded using a standard electrocardiograph. ECG abnormalities included left ventricular hypertrophy (Minnesota code 3-1) and ST depression (4-1, 2, 3). The relation of periodontal condition and ECG abnormalities was assessed with logistic regression analysis. Results: Univariate analysis revealed that mean probing depth, mean attachment loss, number of teeth, and plaque index were significantly associated with ECG abnormalities, as well as with known risk factors of CVD. In multivariate analysis, the subjects with deep pockets (mean probing depth ≥2 mm) had an increased risk for ECG abnormalities (odds ratio [OR] = 1.6; 95{\%} confidence interval [CI] = 1.01 to 2.50) compared to the subjects with mean PD <2 mm. Subjects with severe attachment loss (mean CAL ≥2.5 mm) had also significant risk for ECG abnormalities (OR = 1.7; 95{\%} CI = 1.07 to 2.67) compared to those whose mean CAL was <2.5 mm. Conclusion: This study clearly shows the relationship between periodontitis and ECG abnormalities, which are important predictors of CVD.",
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Relationship between electrocardiographic abnormalities and periodontal disease : The Hisayama study. / Shimazaki, Yoshihiro; Saito, Toshiyuki; Kiyohara, Yutaka; Kato, Isao; Kubo, Michiaki; Iida, Mitsuo; Koga, Toshihiko.

In: Journal of Periodontology, Vol. 75, No. 6, 01.06.2004, p. 791-797.

Research output: Contribution to journalArticle

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T1 - Relationship between electrocardiographic abnormalities and periodontal disease

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AU - Shimazaki, Yoshihiro

AU - Saito, Toshiyuki

AU - Kiyohara, Yutaka

AU - Kato, Isao

AU - Kubo, Michiaki

AU - Iida, Mitsuo

AU - Koga, Toshihiko

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N2 - Background: Recent studies have suggested a relationship between periodontitis and cardiovascular disease (CVD). This study investigated the relationship between periodontitis and electrocardiographic (ECG) abnormalities, which are known predictors of CVD. Methods: We examined the periodontal status of 1,111 residents of Hisayama Town, Fukuoka, Japan. Nine hundred fifty-seven (957) subjects (374 males, 583 females) with ≥10 teeth and without a medical history of CVD were included in the analysis. Probing depth (PD) and clinical attachment level (CAL) were measured on two randomly selected quadrants, one maxillary and one mandibular. A 12-lead ECG was recorded using a standard electrocardiograph. ECG abnormalities included left ventricular hypertrophy (Minnesota code 3-1) and ST depression (4-1, 2, 3). The relation of periodontal condition and ECG abnormalities was assessed with logistic regression analysis. Results: Univariate analysis revealed that mean probing depth, mean attachment loss, number of teeth, and plaque index were significantly associated with ECG abnormalities, as well as with known risk factors of CVD. In multivariate analysis, the subjects with deep pockets (mean probing depth ≥2 mm) had an increased risk for ECG abnormalities (odds ratio [OR] = 1.6; 95% confidence interval [CI] = 1.01 to 2.50) compared to the subjects with mean PD <2 mm. Subjects with severe attachment loss (mean CAL ≥2.5 mm) had also significant risk for ECG abnormalities (OR = 1.7; 95% CI = 1.07 to 2.67) compared to those whose mean CAL was <2.5 mm. Conclusion: This study clearly shows the relationship between periodontitis and ECG abnormalities, which are important predictors of CVD.

AB - Background: Recent studies have suggested a relationship between periodontitis and cardiovascular disease (CVD). This study investigated the relationship between periodontitis and electrocardiographic (ECG) abnormalities, which are known predictors of CVD. Methods: We examined the periodontal status of 1,111 residents of Hisayama Town, Fukuoka, Japan. Nine hundred fifty-seven (957) subjects (374 males, 583 females) with ≥10 teeth and without a medical history of CVD were included in the analysis. Probing depth (PD) and clinical attachment level (CAL) were measured on two randomly selected quadrants, one maxillary and one mandibular. A 12-lead ECG was recorded using a standard electrocardiograph. ECG abnormalities included left ventricular hypertrophy (Minnesota code 3-1) and ST depression (4-1, 2, 3). The relation of periodontal condition and ECG abnormalities was assessed with logistic regression analysis. Results: Univariate analysis revealed that mean probing depth, mean attachment loss, number of teeth, and plaque index were significantly associated with ECG abnormalities, as well as with known risk factors of CVD. In multivariate analysis, the subjects with deep pockets (mean probing depth ≥2 mm) had an increased risk for ECG abnormalities (odds ratio [OR] = 1.6; 95% confidence interval [CI] = 1.01 to 2.50) compared to the subjects with mean PD <2 mm. Subjects with severe attachment loss (mean CAL ≥2.5 mm) had also significant risk for ECG abnormalities (OR = 1.7; 95% CI = 1.07 to 2.67) compared to those whose mean CAL was <2.5 mm. Conclusion: This study clearly shows the relationship between periodontitis and ECG abnormalities, which are important predictors of CVD.

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