Relationship between expression of onco-related miRNAs and the endoscopic appearance of colorectal tumors

Yoshihito Nakagawa, Yukihiro Akao, Kohei Taniguchi, Akemi Kamatani, Tomomitsu Tahara, Toshiaki Kamano, Naoko Nakano, Naruomi Komura, Hirokazu Ikuno, Takafumi Ohmori, Yasutaka Jodai, Masahiro Miyata, Mistuo Nagasaka, Tomoyuki Shibata, Naoki Omiya, Ichiro Hirata

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Accumulating data indicates that certain microRNAs (miRNAs or miRs) are differently expressed in samples of tumors and paired non-tumorous samples taken from the same patients with colorectal tumors. We examined the expression of onco-related miRNAs in 131 sporadic exophytic adenomas or early cancers and in 52 sporadic flat elevated adenomas or early cancers to clarify the relationship between the expression of the miRNAs and the endoscopic morphological appearance of the colorectal tumors. The expression levels of miR-143, -145, and -34a were significantly reduced in most of the exophytic tumors compared with those in the flat elevated ones. In type 2 cancers, the miRNA expression profile was very similar to that of the exophytic tumors. The expression levels of miR-7 and -21 were significantly up-regulated in some flat elevated adenomas compared with those in exophytic adenomas. In contrast, in most of the miR-143 and -145 down-regulated cases of the adenoma-carcinoma sequence and in some of the de novo types of carcinoma, the up-regulation of oncogenic miR-7 and/or -21 contributed to the triggering mechanism leading to the carcinogenetic process. These findings indicated that the expression of onco-related miRNA was associated with the morphological appearance of colorectal tumors.

Original languageEnglish
Pages (from-to)1526-1543
Number of pages18
JournalInternational journal of molecular sciences
Volume16
Issue number1
DOIs
Publication statusPublished - 09-01-2015

Fingerprint

MicroRNAs
Tumors
Colorectal Neoplasms
Adenoma
tumors
cancer
Neoplasms
Carcinoma
Up-Regulation
profiles

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

Cite this

Nakagawa, Yoshihito ; Akao, Yukihiro ; Taniguchi, Kohei ; Kamatani, Akemi ; Tahara, Tomomitsu ; Kamano, Toshiaki ; Nakano, Naoko ; Komura, Naruomi ; Ikuno, Hirokazu ; Ohmori, Takafumi ; Jodai, Yasutaka ; Miyata, Masahiro ; Nagasaka, Mistuo ; Shibata, Tomoyuki ; Omiya, Naoki ; Hirata, Ichiro. / Relationship between expression of onco-related miRNAs and the endoscopic appearance of colorectal tumors. In: International journal of molecular sciences. 2015 ; Vol. 16, No. 1. pp. 1526-1543.
@article{4bddaba852db48928b744f893ab3a588,
title = "Relationship between expression of onco-related miRNAs and the endoscopic appearance of colorectal tumors",
abstract = "Accumulating data indicates that certain microRNAs (miRNAs or miRs) are differently expressed in samples of tumors and paired non-tumorous samples taken from the same patients with colorectal tumors. We examined the expression of onco-related miRNAs in 131 sporadic exophytic adenomas or early cancers and in 52 sporadic flat elevated adenomas or early cancers to clarify the relationship between the expression of the miRNAs and the endoscopic morphological appearance of the colorectal tumors. The expression levels of miR-143, -145, and -34a were significantly reduced in most of the exophytic tumors compared with those in the flat elevated ones. In type 2 cancers, the miRNA expression profile was very similar to that of the exophytic tumors. The expression levels of miR-7 and -21 were significantly up-regulated in some flat elevated adenomas compared with those in exophytic adenomas. In contrast, in most of the miR-143 and -145 down-regulated cases of the adenoma-carcinoma sequence and in some of the de novo types of carcinoma, the up-regulation of oncogenic miR-7 and/or -21 contributed to the triggering mechanism leading to the carcinogenetic process. These findings indicated that the expression of onco-related miRNA was associated with the morphological appearance of colorectal tumors.",
author = "Yoshihito Nakagawa and Yukihiro Akao and Kohei Taniguchi and Akemi Kamatani and Tomomitsu Tahara and Toshiaki Kamano and Naoko Nakano and Naruomi Komura and Hirokazu Ikuno and Takafumi Ohmori and Yasutaka Jodai and Masahiro Miyata and Mistuo Nagasaka and Tomoyuki Shibata and Naoki Omiya and Ichiro Hirata",
year = "2015",
month = "1",
day = "9",
doi = "10.3390/ijms16011526",
language = "English",
volume = "16",
pages = "1526--1543",
journal = "International Journal of Molecular Sciences",
issn = "1661-6596",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "1",

}

Nakagawa, Y, Akao, Y, Taniguchi, K, Kamatani, A, Tahara, T, Kamano, T, Nakano, N, Komura, N, Ikuno, H, Ohmori, T, Jodai, Y, Miyata, M, Nagasaka, M, Shibata, T, Omiya, N & Hirata, I 2015, 'Relationship between expression of onco-related miRNAs and the endoscopic appearance of colorectal tumors', International journal of molecular sciences, vol. 16, no. 1, pp. 1526-1543. https://doi.org/10.3390/ijms16011526

Relationship between expression of onco-related miRNAs and the endoscopic appearance of colorectal tumors. / Nakagawa, Yoshihito; Akao, Yukihiro; Taniguchi, Kohei; Kamatani, Akemi; Tahara, Tomomitsu; Kamano, Toshiaki; Nakano, Naoko; Komura, Naruomi; Ikuno, Hirokazu; Ohmori, Takafumi; Jodai, Yasutaka; Miyata, Masahiro; Nagasaka, Mistuo; Shibata, Tomoyuki; Omiya, Naoki; Hirata, Ichiro.

In: International journal of molecular sciences, Vol. 16, No. 1, 09.01.2015, p. 1526-1543.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Relationship between expression of onco-related miRNAs and the endoscopic appearance of colorectal tumors

AU - Nakagawa, Yoshihito

AU - Akao, Yukihiro

AU - Taniguchi, Kohei

AU - Kamatani, Akemi

AU - Tahara, Tomomitsu

AU - Kamano, Toshiaki

AU - Nakano, Naoko

AU - Komura, Naruomi

AU - Ikuno, Hirokazu

AU - Ohmori, Takafumi

AU - Jodai, Yasutaka

AU - Miyata, Masahiro

AU - Nagasaka, Mistuo

AU - Shibata, Tomoyuki

AU - Omiya, Naoki

AU - Hirata, Ichiro

PY - 2015/1/9

Y1 - 2015/1/9

N2 - Accumulating data indicates that certain microRNAs (miRNAs or miRs) are differently expressed in samples of tumors and paired non-tumorous samples taken from the same patients with colorectal tumors. We examined the expression of onco-related miRNAs in 131 sporadic exophytic adenomas or early cancers and in 52 sporadic flat elevated adenomas or early cancers to clarify the relationship between the expression of the miRNAs and the endoscopic morphological appearance of the colorectal tumors. The expression levels of miR-143, -145, and -34a were significantly reduced in most of the exophytic tumors compared with those in the flat elevated ones. In type 2 cancers, the miRNA expression profile was very similar to that of the exophytic tumors. The expression levels of miR-7 and -21 were significantly up-regulated in some flat elevated adenomas compared with those in exophytic adenomas. In contrast, in most of the miR-143 and -145 down-regulated cases of the adenoma-carcinoma sequence and in some of the de novo types of carcinoma, the up-regulation of oncogenic miR-7 and/or -21 contributed to the triggering mechanism leading to the carcinogenetic process. These findings indicated that the expression of onco-related miRNA was associated with the morphological appearance of colorectal tumors.

AB - Accumulating data indicates that certain microRNAs (miRNAs or miRs) are differently expressed in samples of tumors and paired non-tumorous samples taken from the same patients with colorectal tumors. We examined the expression of onco-related miRNAs in 131 sporadic exophytic adenomas or early cancers and in 52 sporadic flat elevated adenomas or early cancers to clarify the relationship between the expression of the miRNAs and the endoscopic morphological appearance of the colorectal tumors. The expression levels of miR-143, -145, and -34a were significantly reduced in most of the exophytic tumors compared with those in the flat elevated ones. In type 2 cancers, the miRNA expression profile was very similar to that of the exophytic tumors. The expression levels of miR-7 and -21 were significantly up-regulated in some flat elevated adenomas compared with those in exophytic adenomas. In contrast, in most of the miR-143 and -145 down-regulated cases of the adenoma-carcinoma sequence and in some of the de novo types of carcinoma, the up-regulation of oncogenic miR-7 and/or -21 contributed to the triggering mechanism leading to the carcinogenetic process. These findings indicated that the expression of onco-related miRNA was associated with the morphological appearance of colorectal tumors.

UR - http://www.scopus.com/inward/record.url?scp=84920973477&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84920973477&partnerID=8YFLogxK

U2 - 10.3390/ijms16011526

DO - 10.3390/ijms16011526

M3 - Article

C2 - 25584614

AN - SCOPUS:84920973477

VL - 16

SP - 1526

EP - 1543

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

SN - 1661-6596

IS - 1

ER -