Relationship between G1287A of the net gene polymorphisms and brain volume in major depressive disorder

A voxel-based MRI study

Issei Ueda, Shingo Kakeda, Keita Watanabe, Reiji Yoshimura, Taro Kishi, Osamu Abe, Satoru Ide, Junji Moriya, Asuka Katsuki, Hikaru Hori, Nakao Iwata, Jun Nakamura, Yukunori Korogi

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background Earlier studies implicated norepinephrine transporter (NET) gene (SLC6A2) polymorphisms in the etiology of major depressive disorder (MDD). Recently, two single nucleotide SLC6A2 polymorphisms, G1287A in exon 9 and T-182C in the promoter region, were found to be associated with MDD in different populations. We investigated the relationship between the brain volume and these two polymorphisms of the SLC6A2 in MDD patients. Methods We obtained 3D high-resolution T1-weighted images of 30 first-episode MDD patients and 48 age- and sex-matched healthy subjects (HS). All were divided into 4 groups based on polymorphism of either the G1287A or the T-182C genotype. VBM analysis examined the effects of diagnosis, genotype, and genotype-diagnosis interactions. Results Diagnosis effects on the brain morphology were found in the left superior temporal cortex. No significant genotype effects were found in the T-182C and the G1287A. A significant genotype (G1287A)-diagnosis interaction was found in the left dorsolateral prefrontal cortex. No significant genotype (T-182C)-diagnosis interaction effects were observed in any brain region. Conclusions In MDD patients there seems to be a relationship between the volume of the dorsolateral prefrontal cortex and polymorphism of the SLC6A2 G1287A gene.

Original languageEnglish
Article numbere0150712
JournalPloS one
Volume11
Issue number3
DOIs
Publication statusPublished - 01-03-2016

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Major Depressive Disorder
Polymorphism
Magnetic resonance imaging
Brain
Genes
Genotype
genetic polymorphism
brain
genotype
genes
Prefrontal Cortex
Norepinephrine Plasma Membrane Transport Proteins
Genetic Promoter Regions
Temporal Lobe
norepinephrine
Exons
Nucleotides
single nucleotide polymorphism
exons
Single Nucleotide Polymorphism

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Ueda, Issei ; Kakeda, Shingo ; Watanabe, Keita ; Yoshimura, Reiji ; Kishi, Taro ; Abe, Osamu ; Ide, Satoru ; Moriya, Junji ; Katsuki, Asuka ; Hori, Hikaru ; Iwata, Nakao ; Nakamura, Jun ; Korogi, Yukunori. / Relationship between G1287A of the net gene polymorphisms and brain volume in major depressive disorder : A voxel-based MRI study. In: PloS one. 2016 ; Vol. 11, No. 3.
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title = "Relationship between G1287A of the net gene polymorphisms and brain volume in major depressive disorder: A voxel-based MRI study",
abstract = "Background Earlier studies implicated norepinephrine transporter (NET) gene (SLC6A2) polymorphisms in the etiology of major depressive disorder (MDD). Recently, two single nucleotide SLC6A2 polymorphisms, G1287A in exon 9 and T-182C in the promoter region, were found to be associated with MDD in different populations. We investigated the relationship between the brain volume and these two polymorphisms of the SLC6A2 in MDD patients. Methods We obtained 3D high-resolution T1-weighted images of 30 first-episode MDD patients and 48 age- and sex-matched healthy subjects (HS). All were divided into 4 groups based on polymorphism of either the G1287A or the T-182C genotype. VBM analysis examined the effects of diagnosis, genotype, and genotype-diagnosis interactions. Results Diagnosis effects on the brain morphology were found in the left superior temporal cortex. No significant genotype effects were found in the T-182C and the G1287A. A significant genotype (G1287A)-diagnosis interaction was found in the left dorsolateral prefrontal cortex. No significant genotype (T-182C)-diagnosis interaction effects were observed in any brain region. Conclusions In MDD patients there seems to be a relationship between the volume of the dorsolateral prefrontal cortex and polymorphism of the SLC6A2 G1287A gene.",
author = "Issei Ueda and Shingo Kakeda and Keita Watanabe and Reiji Yoshimura and Taro Kishi and Osamu Abe and Satoru Ide and Junji Moriya and Asuka Katsuki and Hikaru Hori and Nakao Iwata and Jun Nakamura and Yukunori Korogi",
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Ueda, I, Kakeda, S, Watanabe, K, Yoshimura, R, Kishi, T, Abe, O, Ide, S, Moriya, J, Katsuki, A, Hori, H, Iwata, N, Nakamura, J & Korogi, Y 2016, 'Relationship between G1287A of the net gene polymorphisms and brain volume in major depressive disorder: A voxel-based MRI study', PloS one, vol. 11, no. 3, e0150712. https://doi.org/10.1371/journal.pone.0150712

Relationship between G1287A of the net gene polymorphisms and brain volume in major depressive disorder : A voxel-based MRI study. / Ueda, Issei; Kakeda, Shingo; Watanabe, Keita; Yoshimura, Reiji; Kishi, Taro; Abe, Osamu; Ide, Satoru; Moriya, Junji; Katsuki, Asuka; Hori, Hikaru; Iwata, Nakao; Nakamura, Jun; Korogi, Yukunori.

In: PloS one, Vol. 11, No. 3, e0150712, 01.03.2016.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Relationship between G1287A of the net gene polymorphisms and brain volume in major depressive disorder

T2 - A voxel-based MRI study

AU - Ueda, Issei

AU - Kakeda, Shingo

AU - Watanabe, Keita

AU - Yoshimura, Reiji

AU - Kishi, Taro

AU - Abe, Osamu

AU - Ide, Satoru

AU - Moriya, Junji

AU - Katsuki, Asuka

AU - Hori, Hikaru

AU - Iwata, Nakao

AU - Nakamura, Jun

AU - Korogi, Yukunori

PY - 2016/3/1

Y1 - 2016/3/1

N2 - Background Earlier studies implicated norepinephrine transporter (NET) gene (SLC6A2) polymorphisms in the etiology of major depressive disorder (MDD). Recently, two single nucleotide SLC6A2 polymorphisms, G1287A in exon 9 and T-182C in the promoter region, were found to be associated with MDD in different populations. We investigated the relationship between the brain volume and these two polymorphisms of the SLC6A2 in MDD patients. Methods We obtained 3D high-resolution T1-weighted images of 30 first-episode MDD patients and 48 age- and sex-matched healthy subjects (HS). All were divided into 4 groups based on polymorphism of either the G1287A or the T-182C genotype. VBM analysis examined the effects of diagnosis, genotype, and genotype-diagnosis interactions. Results Diagnosis effects on the brain morphology were found in the left superior temporal cortex. No significant genotype effects were found in the T-182C and the G1287A. A significant genotype (G1287A)-diagnosis interaction was found in the left dorsolateral prefrontal cortex. No significant genotype (T-182C)-diagnosis interaction effects were observed in any brain region. Conclusions In MDD patients there seems to be a relationship between the volume of the dorsolateral prefrontal cortex and polymorphism of the SLC6A2 G1287A gene.

AB - Background Earlier studies implicated norepinephrine transporter (NET) gene (SLC6A2) polymorphisms in the etiology of major depressive disorder (MDD). Recently, two single nucleotide SLC6A2 polymorphisms, G1287A in exon 9 and T-182C in the promoter region, were found to be associated with MDD in different populations. We investigated the relationship between the brain volume and these two polymorphisms of the SLC6A2 in MDD patients. Methods We obtained 3D high-resolution T1-weighted images of 30 first-episode MDD patients and 48 age- and sex-matched healthy subjects (HS). All were divided into 4 groups based on polymorphism of either the G1287A or the T-182C genotype. VBM analysis examined the effects of diagnosis, genotype, and genotype-diagnosis interactions. Results Diagnosis effects on the brain morphology were found in the left superior temporal cortex. No significant genotype effects were found in the T-182C and the G1287A. A significant genotype (G1287A)-diagnosis interaction was found in the left dorsolateral prefrontal cortex. No significant genotype (T-182C)-diagnosis interaction effects were observed in any brain region. Conclusions In MDD patients there seems to be a relationship between the volume of the dorsolateral prefrontal cortex and polymorphism of the SLC6A2 G1287A gene.

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U2 - 10.1371/journal.pone.0150712

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