TY - JOUR
T1 - Relationship between handgrip strength and albuminuria in community-dwelling elderly Japanese subjects
T2 - the Shika Study
AU - Hara, Akinori
AU - Tsujiguchi, Hiromasa
AU - Suzuki, Keita
AU - Tao, Yuichi
AU - Nakamura, Haruki
AU - Kasahara, Tomoko
AU - Nguyen, Thao Thi Thu
AU - Miyagi, Sakae
AU - Shimizu, Yukari
AU - Kannon, Takayuki
AU - Tajima, Atsushi
AU - Wada, Takashi
AU - Takamura, Toshinari
AU - Nakamura, Hiroyuki
N1 - Publisher Copyright:
© 2020 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2020/10/2
Y1 - 2020/10/2
N2 - Purpose: This study aimed to investigate the association between handgrip strength (HGS) and albuminuria in the general population of Japan as per sex and age. Methods: This population-based, cross-sectional study enrolled 916 Japanese participants aged ≥40 years. Albuminuria was measured and expressed as the urinary albumin-to-creatinine ratio (UACR). Biochemical, nutritional, and anthropometric profiles as well as HGS were measured using standardised protocols. Results: Four hundred and thirty-two (47%) of the study participants were men, and 484 were women, with respective mean ages of 62 ± 11 years and 63 ± 11 years. HGS, older age, high body mass index, presence of hypertension or diabetes, and a decreased estimated glomerular filtration rate were correlated with the log-transformed UACR in subjects of both sexes. Multivariate linear regression analysis showed that HGS was independently associated with the log UACR in both, men [beta coefficient −0.43; 95% confidence interval (CI) −0.73, −0.13] and women (beta coefficient −0.50; 95% CI −0.90, −0.10) aged ≥65 years; however, a similar association was not observed in younger participants. Conclusion: Low HGS was associated with albuminuria in older men and women in Japan.
AB - Purpose: This study aimed to investigate the association between handgrip strength (HGS) and albuminuria in the general population of Japan as per sex and age. Methods: This population-based, cross-sectional study enrolled 916 Japanese participants aged ≥40 years. Albuminuria was measured and expressed as the urinary albumin-to-creatinine ratio (UACR). Biochemical, nutritional, and anthropometric profiles as well as HGS were measured using standardised protocols. Results: Four hundred and thirty-two (47%) of the study participants were men, and 484 were women, with respective mean ages of 62 ± 11 years and 63 ± 11 years. HGS, older age, high body mass index, presence of hypertension or diabetes, and a decreased estimated glomerular filtration rate were correlated with the log-transformed UACR in subjects of both sexes. Multivariate linear regression analysis showed that HGS was independently associated with the log UACR in both, men [beta coefficient −0.43; 95% confidence interval (CI) −0.73, −0.13] and women (beta coefficient −0.50; 95% CI −0.90, −0.10) aged ≥65 years; however, a similar association was not observed in younger participants. Conclusion: Low HGS was associated with albuminuria in older men and women in Japan.
KW - Handgrip strength
KW - albuminuria
KW - frailty
KW - lifestyle
KW - nutrition
KW - sarcopenia
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U2 - 10.1080/1354750X.2020.1819418
DO - 10.1080/1354750X.2020.1819418
M3 - Article
C2 - 32893687
AN - SCOPUS:85091150740
SN - 1354-750X
VL - 25
SP - 587
EP - 593
JO - Biomarkers
JF - Biomarkers
IS - 7
ER -