Relationship between nutritional therapy and surgery in Crohn's disease

Hironao Takahashi, Takafumi Ando, Osamu Watanabe, Osamu Maeda, Kazuhiro Ishiguro, Daisuke Ishikawa, Motofusa Hasegawa, Masaaki Minami, Yasuyuki Goto, Kazuo Kusugami, Kenji Ina, Naoki Ohmiya, Yasumasa Niwa, Hidemi Goto

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background/Aims: Crohn's disease is often refractory and some patients require repeated surgical treatment. Nutritional therapy with an elemental diet has been reported effective in improving nutritional state and suppressing inflammation, and might be expected to assist in minimizing the need for surgery. We evaluated the relationship between an elemental diet and the period that patients spent without intestinal resection. Methodology: A total of 153 patients with Crohn's disease who visited our hospital from July, 1999 to July, 2005 were enrolled. The relationship between the caloric content of an elemental diet and surgery as an endpoint was examined using Cox regression analysis. Cumulative non-operation rates were calculated by the Kaplan-Meier method. Statistical significance was determined using the log-rank test. Results: Among patients with jejunoileal involvement, patients receiving an elemental diet providing 900 kcal or more per day showed a statistically significant improvement in cumulative non-operation rate. Among those without jejunoileal involvement, in contrast, the cumulative non-operation rate did not differ among those receiving an elemental diet of less or more than 900 kcal per day. Conclusions: The use of an elemental diet of 900 kcal per day may be effective in avoiding surgery in patients with jejunoileal lesions. This diet may be useful in improving long-term convalescence in these patients.

Original languageEnglish
Pages (from-to)1044-1048
Number of pages5
JournalHepato-Gastroenterology
Volume56
Issue number93
Publication statusPublished - 01-07-2009
Externally publishedYes

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Formulated Food
Crohn Disease
Therapeutics
Regression Analysis
Diet
Inflammation

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

Cite this

Takahashi, H., Ando, T., Watanabe, O., Maeda, O., Ishiguro, K., Ishikawa, D., ... Goto, H. (2009). Relationship between nutritional therapy and surgery in Crohn's disease. Hepato-Gastroenterology, 56(93), 1044-1048.
Takahashi, Hironao ; Ando, Takafumi ; Watanabe, Osamu ; Maeda, Osamu ; Ishiguro, Kazuhiro ; Ishikawa, Daisuke ; Hasegawa, Motofusa ; Minami, Masaaki ; Goto, Yasuyuki ; Kusugami, Kazuo ; Ina, Kenji ; Ohmiya, Naoki ; Niwa, Yasumasa ; Goto, Hidemi. / Relationship between nutritional therapy and surgery in Crohn's disease. In: Hepato-Gastroenterology. 2009 ; Vol. 56, No. 93. pp. 1044-1048.
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abstract = "Background/Aims: Crohn's disease is often refractory and some patients require repeated surgical treatment. Nutritional therapy with an elemental diet has been reported effective in improving nutritional state and suppressing inflammation, and might be expected to assist in minimizing the need for surgery. We evaluated the relationship between an elemental diet and the period that patients spent without intestinal resection. Methodology: A total of 153 patients with Crohn's disease who visited our hospital from July, 1999 to July, 2005 were enrolled. The relationship between the caloric content of an elemental diet and surgery as an endpoint was examined using Cox regression analysis. Cumulative non-operation rates were calculated by the Kaplan-Meier method. Statistical significance was determined using the log-rank test. Results: Among patients with jejunoileal involvement, patients receiving an elemental diet providing 900 kcal or more per day showed a statistically significant improvement in cumulative non-operation rate. Among those without jejunoileal involvement, in contrast, the cumulative non-operation rate did not differ among those receiving an elemental diet of less or more than 900 kcal per day. Conclusions: The use of an elemental diet of 900 kcal per day may be effective in avoiding surgery in patients with jejunoileal lesions. This diet may be useful in improving long-term convalescence in these patients.",
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Takahashi, H, Ando, T, Watanabe, O, Maeda, O, Ishiguro, K, Ishikawa, D, Hasegawa, M, Minami, M, Goto, Y, Kusugami, K, Ina, K, Ohmiya, N, Niwa, Y & Goto, H 2009, 'Relationship between nutritional therapy and surgery in Crohn's disease', Hepato-Gastroenterology, vol. 56, no. 93, pp. 1044-1048.

Relationship between nutritional therapy and surgery in Crohn's disease. / Takahashi, Hironao; Ando, Takafumi; Watanabe, Osamu; Maeda, Osamu; Ishiguro, Kazuhiro; Ishikawa, Daisuke; Hasegawa, Motofusa; Minami, Masaaki; Goto, Yasuyuki; Kusugami, Kazuo; Ina, Kenji; Ohmiya, Naoki; Niwa, Yasumasa; Goto, Hidemi.

In: Hepato-Gastroenterology, Vol. 56, No. 93, 01.07.2009, p. 1044-1048.

Research output: Contribution to journalArticle

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T1 - Relationship between nutritional therapy and surgery in Crohn's disease

AU - Takahashi, Hironao

AU - Ando, Takafumi

AU - Watanabe, Osamu

AU - Maeda, Osamu

AU - Ishiguro, Kazuhiro

AU - Ishikawa, Daisuke

AU - Hasegawa, Motofusa

AU - Minami, Masaaki

AU - Goto, Yasuyuki

AU - Kusugami, Kazuo

AU - Ina, Kenji

AU - Ohmiya, Naoki

AU - Niwa, Yasumasa

AU - Goto, Hidemi

PY - 2009/7/1

Y1 - 2009/7/1

N2 - Background/Aims: Crohn's disease is often refractory and some patients require repeated surgical treatment. Nutritional therapy with an elemental diet has been reported effective in improving nutritional state and suppressing inflammation, and might be expected to assist in minimizing the need for surgery. We evaluated the relationship between an elemental diet and the period that patients spent without intestinal resection. Methodology: A total of 153 patients with Crohn's disease who visited our hospital from July, 1999 to July, 2005 were enrolled. The relationship between the caloric content of an elemental diet and surgery as an endpoint was examined using Cox regression analysis. Cumulative non-operation rates were calculated by the Kaplan-Meier method. Statistical significance was determined using the log-rank test. Results: Among patients with jejunoileal involvement, patients receiving an elemental diet providing 900 kcal or more per day showed a statistically significant improvement in cumulative non-operation rate. Among those without jejunoileal involvement, in contrast, the cumulative non-operation rate did not differ among those receiving an elemental diet of less or more than 900 kcal per day. Conclusions: The use of an elemental diet of 900 kcal per day may be effective in avoiding surgery in patients with jejunoileal lesions. This diet may be useful in improving long-term convalescence in these patients.

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Takahashi H, Ando T, Watanabe O, Maeda O, Ishiguro K, Ishikawa D et al. Relationship between nutritional therapy and surgery in Crohn's disease. Hepato-Gastroenterology. 2009 Jul 1;56(93):1044-1048.