Relationship between obesity and serum markers of oxidative stress and inflammation in japanese

Koji Suzuki, Yoshinori Ito, Junichi Ochiai, Yasuhiro Kusuhara, Shuji Hashimoto, Shinkan Tokudome, Masayo Kojima, Kenji Wakai, Hideaki Toyoshima, Koji Tamakoshi, Yoshiyuki Watanabe, Norihiko Hayakawa, Morito Maruta, Makoto Watanabe, Kazuo Kato, Yoshiji Ohta, Akiko Tamakoshi

Research output: Contribution to journalArticle

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Abstract

The present study was conducted to assess the relationship between obesity and serum levels of C-reactive protein (CRP), carotenoids, oxidized LDL (oxLDL), oxidized LDL antibodies (oLAB), and leptin in Japanese residents. The subjects were 158 males and 158 females aged 40-79 years, and living in Hokkaido, Japan, who attended a health examination screening. Serum levels of CRP, oxLDL, oLAB, and leptin were measured by enzyme-linked immunosorbent assay (ELISA) and serum carotenoid levels were measured by high-performance liquid chromatography (HPLC). Body mass index (BMI) was calculated as body weight (kg) divided by height (m) squared and obesity was defined as BMI of 25 or more (kg/m2). Serum levels of CRP and leptin were significantly higher in the obese group than in their non-obese counterparts in both genders. Serum levels of β-carotene and β-cryptoxanthin were lower in the obese individuals, especially in females. While values for oxLDL and oLAB did not significantly vary. BMI was positively correlated with logtransformed serum levels of CRP and leptin in both genders (males: r=0.231, p<0.05; females: r=0.305, p<0.001). In females, moreover, BMI was negatively correlated with log-transformed serum levels of β-carotene, zeaxanthin/ lutein, and β-cryptoxanthin (r=-0.244, p<0.01; r=-0.200, p<0.05; r=-0.207, p<0.01, respectively). Significantly higher odds ratios (ORs) for high serum levels of CRP (males: OR=2.12; females: OR=3.96) and leptin (males: OR=3.83; females: OR=9.07) were observed in obese versus non-obese men and women, after adjusting for various confounding factors. Significantly lower adjusted odds ratios for high serum levels of α- and β-carotenes (males: OR=0.23, 0.33; females: OR=0.35, 0.39, respectively) were also observed in the obese as compared to the non-obese group. In conclusion, obesity is highly associated with states of oxidative stress and low-grade inflammation in Japanese residents, suggesting that these latter might play an important role in the association between a high BMI and certain cancers as well as coronary heart disease (CHD).

Original languageEnglish
Pages (from-to)259-266
Number of pages8
JournalAsian Pacific Journal of Cancer Prevention
Volume4
Issue number3
Publication statusPublished - 01-01-2003

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Oxidative Stress
Obesity
Biomarkers
Inflammation
Odds Ratio
Carotenoids
Leptin
C-Reactive Protein
Serum
Body Mass Index
Antibodies
Lutein
Coronary Disease
oxidized low density lipoprotein
Japan
Enzyme-Linked Immunosorbent Assay
High Pressure Liquid Chromatography
Body Weight
Health
Neoplasms

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Oncology
  • Public Health, Environmental and Occupational Health
  • Cancer Research

Cite this

Suzuki, Koji ; Ito, Yoshinori ; Ochiai, Junichi ; Kusuhara, Yasuhiro ; Hashimoto, Shuji ; Tokudome, Shinkan ; Kojima, Masayo ; Wakai, Kenji ; Toyoshima, Hideaki ; Tamakoshi, Koji ; Watanabe, Yoshiyuki ; Hayakawa, Norihiko ; Maruta, Morito ; Watanabe, Makoto ; Kato, Kazuo ; Ohta, Yoshiji ; Tamakoshi, Akiko. / Relationship between obesity and serum markers of oxidative stress and inflammation in japanese. In: Asian Pacific Journal of Cancer Prevention. 2003 ; Vol. 4, No. 3. pp. 259-266.
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abstract = "The present study was conducted to assess the relationship between obesity and serum levels of C-reactive protein (CRP), carotenoids, oxidized LDL (oxLDL), oxidized LDL antibodies (oLAB), and leptin in Japanese residents. The subjects were 158 males and 158 females aged 40-79 years, and living in Hokkaido, Japan, who attended a health examination screening. Serum levels of CRP, oxLDL, oLAB, and leptin were measured by enzyme-linked immunosorbent assay (ELISA) and serum carotenoid levels were measured by high-performance liquid chromatography (HPLC). Body mass index (BMI) was calculated as body weight (kg) divided by height (m) squared and obesity was defined as BMI of 25 or more (kg/m2). Serum levels of CRP and leptin were significantly higher in the obese group than in their non-obese counterparts in both genders. Serum levels of β-carotene and β-cryptoxanthin were lower in the obese individuals, especially in females. While values for oxLDL and oLAB did not significantly vary. BMI was positively correlated with logtransformed serum levels of CRP and leptin in both genders (males: r=0.231, p<0.05; females: r=0.305, p<0.001). In females, moreover, BMI was negatively correlated with log-transformed serum levels of β-carotene, zeaxanthin/ lutein, and β-cryptoxanthin (r=-0.244, p<0.01; r=-0.200, p<0.05; r=-0.207, p<0.01, respectively). Significantly higher odds ratios (ORs) for high serum levels of CRP (males: OR=2.12; females: OR=3.96) and leptin (males: OR=3.83; females: OR=9.07) were observed in obese versus non-obese men and women, after adjusting for various confounding factors. Significantly lower adjusted odds ratios for high serum levels of α- and β-carotenes (males: OR=0.23, 0.33; females: OR=0.35, 0.39, respectively) were also observed in the obese as compared to the non-obese group. In conclusion, obesity is highly associated with states of oxidative stress and low-grade inflammation in Japanese residents, suggesting that these latter might play an important role in the association between a high BMI and certain cancers as well as coronary heart disease (CHD).",
author = "Koji Suzuki and Yoshinori Ito and Junichi Ochiai and Yasuhiro Kusuhara and Shuji Hashimoto and Shinkan Tokudome and Masayo Kojima and Kenji Wakai and Hideaki Toyoshima and Koji Tamakoshi and Yoshiyuki Watanabe and Norihiko Hayakawa and Morito Maruta and Makoto Watanabe and Kazuo Kato and Yoshiji Ohta and Akiko Tamakoshi",
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Suzuki, K, Ito, Y, Ochiai, J, Kusuhara, Y, Hashimoto, S, Tokudome, S, Kojima, M, Wakai, K, Toyoshima, H, Tamakoshi, K, Watanabe, Y, Hayakawa, N, Maruta, M, Watanabe, M, Kato, K, Ohta, Y & Tamakoshi, A 2003, 'Relationship between obesity and serum markers of oxidative stress and inflammation in japanese', Asian Pacific Journal of Cancer Prevention, vol. 4, no. 3, pp. 259-266.

Relationship between obesity and serum markers of oxidative stress and inflammation in japanese. / Suzuki, Koji; Ito, Yoshinori; Ochiai, Junichi; Kusuhara, Yasuhiro; Hashimoto, Shuji; Tokudome, Shinkan; Kojima, Masayo; Wakai, Kenji; Toyoshima, Hideaki; Tamakoshi, Koji; Watanabe, Yoshiyuki; Hayakawa, Norihiko; Maruta, Morito; Watanabe, Makoto; Kato, Kazuo; Ohta, Yoshiji; Tamakoshi, Akiko.

In: Asian Pacific Journal of Cancer Prevention, Vol. 4, No. 3, 01.01.2003, p. 259-266.

Research output: Contribution to journalArticle

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T1 - Relationship between obesity and serum markers of oxidative stress and inflammation in japanese

AU - Suzuki, Koji

AU - Ito, Yoshinori

AU - Ochiai, Junichi

AU - Kusuhara, Yasuhiro

AU - Hashimoto, Shuji

AU - Tokudome, Shinkan

AU - Kojima, Masayo

AU - Wakai, Kenji

AU - Toyoshima, Hideaki

AU - Tamakoshi, Koji

AU - Watanabe, Yoshiyuki

AU - Hayakawa, Norihiko

AU - Maruta, Morito

AU - Watanabe, Makoto

AU - Kato, Kazuo

AU - Ohta, Yoshiji

AU - Tamakoshi, Akiko

PY - 2003/1/1

Y1 - 2003/1/1

N2 - The present study was conducted to assess the relationship between obesity and serum levels of C-reactive protein (CRP), carotenoids, oxidized LDL (oxLDL), oxidized LDL antibodies (oLAB), and leptin in Japanese residents. The subjects were 158 males and 158 females aged 40-79 years, and living in Hokkaido, Japan, who attended a health examination screening. Serum levels of CRP, oxLDL, oLAB, and leptin were measured by enzyme-linked immunosorbent assay (ELISA) and serum carotenoid levels were measured by high-performance liquid chromatography (HPLC). Body mass index (BMI) was calculated as body weight (kg) divided by height (m) squared and obesity was defined as BMI of 25 or more (kg/m2). Serum levels of CRP and leptin were significantly higher in the obese group than in their non-obese counterparts in both genders. Serum levels of β-carotene and β-cryptoxanthin were lower in the obese individuals, especially in females. While values for oxLDL and oLAB did not significantly vary. BMI was positively correlated with logtransformed serum levels of CRP and leptin in both genders (males: r=0.231, p<0.05; females: r=0.305, p<0.001). In females, moreover, BMI was negatively correlated with log-transformed serum levels of β-carotene, zeaxanthin/ lutein, and β-cryptoxanthin (r=-0.244, p<0.01; r=-0.200, p<0.05; r=-0.207, p<0.01, respectively). Significantly higher odds ratios (ORs) for high serum levels of CRP (males: OR=2.12; females: OR=3.96) and leptin (males: OR=3.83; females: OR=9.07) were observed in obese versus non-obese men and women, after adjusting for various confounding factors. Significantly lower adjusted odds ratios for high serum levels of α- and β-carotenes (males: OR=0.23, 0.33; females: OR=0.35, 0.39, respectively) were also observed in the obese as compared to the non-obese group. In conclusion, obesity is highly associated with states of oxidative stress and low-grade inflammation in Japanese residents, suggesting that these latter might play an important role in the association between a high BMI and certain cancers as well as coronary heart disease (CHD).

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