Relationship between peripheral arterial disease and incident disability among elderly Japanese

The Tsurugaya project

Akemi Nitta, Atsushi Hozawa, Shinichi Kuriyama, Naoki Nakaya, Kaori Ohmori-Matsuda, Toshimasa Sone, Masako Kakizaki, Satoru Ebihara, Masataka Ichiki, Hiroyuki Arai, Ichiro Tsuji

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Aim: The aim of this study was to investigate whether peripheral arterial disease (PAD) is predictive of disability and whether the relationship between PAD and disability can be fully explained by baseline physical functions. Methods: We followed for five years 783 Japanese aged 70 years or older without a disability at baseline in 2003. We defined participants certificed as requiring long-term care as having incident disability. The hazard ratio (HR) and 95% confidence interval (95% CI) for incident disability were calculated using the Cox proportional hazards model. Results: After adjusting for possible confounders other than physical function, the HR of incident disability among participants with PAD was 1.86 (95%CI: 1.06 to 3.26). Although the risk was attenuated (HR= 1.63, 95%CI: 0.92 to 2.86) after adding baseline physical function as a covariate, the HR was still high. Furthermore, the relation was not statistically significant, but the group with higher physical function and PAD also had a higher HR of incident disability than those who had higher physical function without PAD. Conclusion: PAD is an important predictor of disability even if the level of baseline physical function is high.

Original languageEnglish
Pages (from-to)1290-1296
Number of pages7
JournalJournal of atherosclerosis and thrombosis
Volume17
Issue number12
DOIs
Publication statusPublished - 01-01-2010

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Peripheral Arterial Disease
Hazards
Long-Term Care
Proportional Hazards Models
Confidence Intervals

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Cardiology and Cardiovascular Medicine
  • Biochemistry, medical

Cite this

Nitta, Akemi ; Hozawa, Atsushi ; Kuriyama, Shinichi ; Nakaya, Naoki ; Ohmori-Matsuda, Kaori ; Sone, Toshimasa ; Kakizaki, Masako ; Ebihara, Satoru ; Ichiki, Masataka ; Arai, Hiroyuki ; Tsuji, Ichiro. / Relationship between peripheral arterial disease and incident disability among elderly Japanese : The Tsurugaya project. In: Journal of atherosclerosis and thrombosis. 2010 ; Vol. 17, No. 12. pp. 1290-1296.
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Nitta, A, Hozawa, A, Kuriyama, S, Nakaya, N, Ohmori-Matsuda, K, Sone, T, Kakizaki, M, Ebihara, S, Ichiki, M, Arai, H & Tsuji, I 2010, 'Relationship between peripheral arterial disease and incident disability among elderly Japanese: The Tsurugaya project', Journal of atherosclerosis and thrombosis, vol. 17, no. 12, pp. 1290-1296. https://doi.org/10.5551/jat.5389

Relationship between peripheral arterial disease and incident disability among elderly Japanese : The Tsurugaya project. / Nitta, Akemi; Hozawa, Atsushi; Kuriyama, Shinichi; Nakaya, Naoki; Ohmori-Matsuda, Kaori; Sone, Toshimasa; Kakizaki, Masako; Ebihara, Satoru; Ichiki, Masataka; Arai, Hiroyuki; Tsuji, Ichiro.

In: Journal of atherosclerosis and thrombosis, Vol. 17, No. 12, 01.01.2010, p. 1290-1296.

Research output: Contribution to journalArticle

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T1 - Relationship between peripheral arterial disease and incident disability among elderly Japanese

T2 - The Tsurugaya project

AU - Nitta, Akemi

AU - Hozawa, Atsushi

AU - Kuriyama, Shinichi

AU - Nakaya, Naoki

AU - Ohmori-Matsuda, Kaori

AU - Sone, Toshimasa

AU - Kakizaki, Masako

AU - Ebihara, Satoru

AU - Ichiki, Masataka

AU - Arai, Hiroyuki

AU - Tsuji, Ichiro

PY - 2010/1/1

Y1 - 2010/1/1

N2 - Aim: The aim of this study was to investigate whether peripheral arterial disease (PAD) is predictive of disability and whether the relationship between PAD and disability can be fully explained by baseline physical functions. Methods: We followed for five years 783 Japanese aged 70 years or older without a disability at baseline in 2003. We defined participants certificed as requiring long-term care as having incident disability. The hazard ratio (HR) and 95% confidence interval (95% CI) for incident disability were calculated using the Cox proportional hazards model. Results: After adjusting for possible confounders other than physical function, the HR of incident disability among participants with PAD was 1.86 (95%CI: 1.06 to 3.26). Although the risk was attenuated (HR= 1.63, 95%CI: 0.92 to 2.86) after adding baseline physical function as a covariate, the HR was still high. Furthermore, the relation was not statistically significant, but the group with higher physical function and PAD also had a higher HR of incident disability than those who had higher physical function without PAD. Conclusion: PAD is an important predictor of disability even if the level of baseline physical function is high.

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