TY - JOUR
T1 - Relationship between peripheral arterial disease and incident disability among elderly Japanese
T2 - The Tsurugaya project
AU - Nitta, Akemi
AU - Hozawa, Atsushi
AU - Kuriyama, Shinichi
AU - Nakaya, Naoki
AU - Ohmori-Matsuda, Kaori
AU - Sone, Toshimasa
AU - Kakizaki, Masako
AU - Ebihara, Satoru
AU - Ichiki, Masataka
AU - Arai, Hiroyuki
AU - Tsuji, Ichiro
PY - 2010
Y1 - 2010
N2 - Aim: The aim of this study was to investigate whether peripheral arterial disease (PAD) is predictive of disability and whether the relationship between PAD and disability can be fully explained by baseline physical functions. Methods: We followed for five years 783 Japanese aged 70 years or older without a disability at baseline in 2003. We defined participants certificed as requiring long-term care as having incident disability. The hazard ratio (HR) and 95% confidence interval (95% CI) for incident disability were calculated using the Cox proportional hazards model. Results: After adjusting for possible confounders other than physical function, the HR of incident disability among participants with PAD was 1.86 (95%CI: 1.06 to 3.26). Although the risk was attenuated (HR= 1.63, 95%CI: 0.92 to 2.86) after adding baseline physical function as a covariate, the HR was still high. Furthermore, the relation was not statistically significant, but the group with higher physical function and PAD also had a higher HR of incident disability than those who had higher physical function without PAD. Conclusion: PAD is an important predictor of disability even if the level of baseline physical function is high.
AB - Aim: The aim of this study was to investigate whether peripheral arterial disease (PAD) is predictive of disability and whether the relationship between PAD and disability can be fully explained by baseline physical functions. Methods: We followed for five years 783 Japanese aged 70 years or older without a disability at baseline in 2003. We defined participants certificed as requiring long-term care as having incident disability. The hazard ratio (HR) and 95% confidence interval (95% CI) for incident disability were calculated using the Cox proportional hazards model. Results: After adjusting for possible confounders other than physical function, the HR of incident disability among participants with PAD was 1.86 (95%CI: 1.06 to 3.26). Although the risk was attenuated (HR= 1.63, 95%CI: 0.92 to 2.86) after adding baseline physical function as a covariate, the HR was still high. Furthermore, the relation was not statistically significant, but the group with higher physical function and PAD also had a higher HR of incident disability than those who had higher physical function without PAD. Conclusion: PAD is an important predictor of disability even if the level of baseline physical function is high.
KW - Incident disability
KW - Japanese elderly prospective cohort study
KW - Long term care insurance certification
KW - Peripheral arterial disease
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U2 - 10.5551/jat.5389
DO - 10.5551/jat.5389
M3 - Article
C2 - 21071882
AN - SCOPUS:78650831900
SN - 1340-3478
VL - 17
SP - 1290
EP - 1296
JO - Journal of atherosclerosis and thrombosis
JF - Journal of atherosclerosis and thrombosis
IS - 12
ER -