TY - JOUR
T1 - Relationship between plasma glutathione levels and cardiovascular disease in a defined population
T2 - The Hisayama study
AU - Shimizu, Haruki
AU - Kiyohara, Yutaka
AU - Kato, Isao
AU - Kitazono, Takanari
AU - Tanizaki, Yumihiro
AU - Kubo, Michiaki
AU - Ueno, Hirofumi
AU - Ibayashi, Setsuro
AU - Fujishima, Masatoshi
AU - Iida, Mitsuo
PY - 2004/9
Y1 - 2004/9
N2 - Background and Purpose-Glutathione (GSH) appears to have marked antioxidant activities and therefore may prevent cardiovascular disease (CVD). However, there are very few reports on this subject. In a community-based case-control study, we tested the hypothesis that low levels of plasma GSH are closely associated with CVD and its clinical types. Methods-The association between fasting plasma total GSH (tGSH) levels and CVD were assessed using conditional logistic regression analysis among 134 CVD cases and 435 age- and sex-matched healthy control subjects. Results-Mean tGSH concentrations were lower in all CVD cases than in the control subjects (3.06 versus 3.71 μmol/L; P=0.0001). Among the CVD types, both the cerebral infarction cases (2.98 versus 3.59 μmol/L; P=0.001) and cerebral hemorrhage cases (2.51 versus 3.43 μmol/L; P=0.0027) had significantly lower tGSH levels than the corresponding control groups had. The same tendency was observed for cases of subarachnoid hemorrhage (3.45 versus 3.83 μmol/L; P=0.36) and myocardial infarction (3.65 versus 3.77 μmol/L; P=0.69), but these differences were not statistically significant. After adjustment for other confounding factors, the risk of CVD was significantly lower in the third (adjusted odds ratio, 041; 95% CI, 0.21 to 0.77) and the fourth quartiles (adjusted odds ratio, 0.25; 95% CI, 0.12 to 0.51) than in the first. This association was most prominent in patients with lacunar infarction or cerebral hemorrhage. Conclusions-These findings suggest that reduced plasma tGSH levels are a risk factor for CVD, especially for cerebral small vessel disease.
AB - Background and Purpose-Glutathione (GSH) appears to have marked antioxidant activities and therefore may prevent cardiovascular disease (CVD). However, there are very few reports on this subject. In a community-based case-control study, we tested the hypothesis that low levels of plasma GSH are closely associated with CVD and its clinical types. Methods-The association between fasting plasma total GSH (tGSH) levels and CVD were assessed using conditional logistic regression analysis among 134 CVD cases and 435 age- and sex-matched healthy control subjects. Results-Mean tGSH concentrations were lower in all CVD cases than in the control subjects (3.06 versus 3.71 μmol/L; P=0.0001). Among the CVD types, both the cerebral infarction cases (2.98 versus 3.59 μmol/L; P=0.001) and cerebral hemorrhage cases (2.51 versus 3.43 μmol/L; P=0.0027) had significantly lower tGSH levels than the corresponding control groups had. The same tendency was observed for cases of subarachnoid hemorrhage (3.45 versus 3.83 μmol/L; P=0.36) and myocardial infarction (3.65 versus 3.77 μmol/L; P=0.69), but these differences were not statistically significant. After adjustment for other confounding factors, the risk of CVD was significantly lower in the third (adjusted odds ratio, 041; 95% CI, 0.21 to 0.77) and the fourth quartiles (adjusted odds ratio, 0.25; 95% CI, 0.12 to 0.51) than in the first. This association was most prominent in patients with lacunar infarction or cerebral hemorrhage. Conclusions-These findings suggest that reduced plasma tGSH levels are a risk factor for CVD, especially for cerebral small vessel disease.
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U2 - 10.1161/01.STR.0000138022.86509.2d
DO - 10.1161/01.STR.0000138022.86509.2d
M3 - Article
C2 - 15256685
AN - SCOPUS:4344679570
SN - 0039-2499
VL - 35
SP - 2072
EP - 2077
JO - Stroke
JF - Stroke
IS - 9
ER -