Relationship between renal function at the time of percutaneous coronary intervention and prognosis in ischemic heart disease patients

Daijo Inaguma, Miho Tatematsu, Hibiki Shinjo, Sachiyo Suzuki, Tomoko Mishima, Shinichiro Inaba, Kei Kurata, Yukio Yuzawa, Seiichi Matsuo

Research output: Contribution to journalReview article

11 Citations (Scopus)

Abstract

Background. As hypertension and diabetes mellitus increase, the number of patients developing complications of cardiovascular disease (CVD) associated with conventional risk factors is increasing. In addition to these risk factors for CVD, chronic kidney disease (CKD) has also been reported to play an important role. We investigated the association of representative ischemic heart disease and CKD. Methods. Between July 1, 2000, and June 30, 2005, a total of 790 patients who underwent percutaneous coronary intervention (PCI) for angina pectoris or myocardial infarction in our division of cardiovascular disease were reviewed. Serum markers at the implementation of PCI were compared in patients classified according to renal function. For prognosis, in-hospital mortality, 1-year survival rate, overall mortality, and CVD death were investigated. Changes in renal function were also monitored during the follow-up period. The glomerular filtration rate (GFR) was calculated by the Modification of Diet in Renal Disease Study Group (MDRD) formula. Results. The mean estimated GFR (eGFR) at PCI implementation was 66.2 ± 21.0 ml/min/1.73 m2. Stage 2 CKD was shown in 51.5% of all the patients. During the overall follow-up period, 126 patients died. With the progression of CKD stage, all-cause, CVD, and in-hospital mortality increased, and the 1-year survival rate decreased. It was proved that a medical history of hypertension, hyperlipidemia, and diabetes, multiple vessel lesions, hypoalbuminemia, C-reactive protein (CRP), and estimated GFR were independent risk factors for all-cause death. In CVD death, in addition to the above risk factors, anemia and total cholesterol were also an independent risk factor. Renal function deteriorated significantly during the follow-up period. Conclusions. Patients with ischemic heart disease requiring PCI often develop renal dysfunction, which may considerably affect prognosis.

Original languageEnglish
Pages (from-to)56-60
Number of pages5
JournalClinical and Experimental Nephrology
Volume11
Issue number1
DOIs
Publication statusPublished - 01-03-2007
Externally publishedYes

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Percutaneous Coronary Intervention
Myocardial Ischemia
Cardiovascular Diseases
Chronic Renal Insufficiency
Kidney
Glomerular Filtration Rate
Hospital Mortality
Survival Rate
Hypertension
Diet Therapy
Hypoalbuminemia
Angina Pectoris
Hyperlipidemias
C-Reactive Protein
Anemia
Cause of Death
Diabetes Mellitus
Biomarkers
Myocardial Infarction
Cholesterol

All Science Journal Classification (ASJC) codes

  • Physiology
  • Nephrology
  • Physiology (medical)

Cite this

Inaguma, Daijo ; Tatematsu, Miho ; Shinjo, Hibiki ; Suzuki, Sachiyo ; Mishima, Tomoko ; Inaba, Shinichiro ; Kurata, Kei ; Yuzawa, Yukio ; Matsuo, Seiichi. / Relationship between renal function at the time of percutaneous coronary intervention and prognosis in ischemic heart disease patients. In: Clinical and Experimental Nephrology. 2007 ; Vol. 11, No. 1. pp. 56-60.
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Relationship between renal function at the time of percutaneous coronary intervention and prognosis in ischemic heart disease patients. / Inaguma, Daijo; Tatematsu, Miho; Shinjo, Hibiki; Suzuki, Sachiyo; Mishima, Tomoko; Inaba, Shinichiro; Kurata, Kei; Yuzawa, Yukio; Matsuo, Seiichi.

In: Clinical and Experimental Nephrology, Vol. 11, No. 1, 01.03.2007, p. 56-60.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Relationship between renal function at the time of percutaneous coronary intervention and prognosis in ischemic heart disease patients

AU - Inaguma, Daijo

AU - Tatematsu, Miho

AU - Shinjo, Hibiki

AU - Suzuki, Sachiyo

AU - Mishima, Tomoko

AU - Inaba, Shinichiro

AU - Kurata, Kei

AU - Yuzawa, Yukio

AU - Matsuo, Seiichi

PY - 2007/3/1

Y1 - 2007/3/1

N2 - Background. As hypertension and diabetes mellitus increase, the number of patients developing complications of cardiovascular disease (CVD) associated with conventional risk factors is increasing. In addition to these risk factors for CVD, chronic kidney disease (CKD) has also been reported to play an important role. We investigated the association of representative ischemic heart disease and CKD. Methods. Between July 1, 2000, and June 30, 2005, a total of 790 patients who underwent percutaneous coronary intervention (PCI) for angina pectoris or myocardial infarction in our division of cardiovascular disease were reviewed. Serum markers at the implementation of PCI were compared in patients classified according to renal function. For prognosis, in-hospital mortality, 1-year survival rate, overall mortality, and CVD death were investigated. Changes in renal function were also monitored during the follow-up period. The glomerular filtration rate (GFR) was calculated by the Modification of Diet in Renal Disease Study Group (MDRD) formula. Results. The mean estimated GFR (eGFR) at PCI implementation was 66.2 ± 21.0 ml/min/1.73 m2. Stage 2 CKD was shown in 51.5% of all the patients. During the overall follow-up period, 126 patients died. With the progression of CKD stage, all-cause, CVD, and in-hospital mortality increased, and the 1-year survival rate decreased. It was proved that a medical history of hypertension, hyperlipidemia, and diabetes, multiple vessel lesions, hypoalbuminemia, C-reactive protein (CRP), and estimated GFR were independent risk factors for all-cause death. In CVD death, in addition to the above risk factors, anemia and total cholesterol were also an independent risk factor. Renal function deteriorated significantly during the follow-up period. Conclusions. Patients with ischemic heart disease requiring PCI often develop renal dysfunction, which may considerably affect prognosis.

AB - Background. As hypertension and diabetes mellitus increase, the number of patients developing complications of cardiovascular disease (CVD) associated with conventional risk factors is increasing. In addition to these risk factors for CVD, chronic kidney disease (CKD) has also been reported to play an important role. We investigated the association of representative ischemic heart disease and CKD. Methods. Between July 1, 2000, and June 30, 2005, a total of 790 patients who underwent percutaneous coronary intervention (PCI) for angina pectoris or myocardial infarction in our division of cardiovascular disease were reviewed. Serum markers at the implementation of PCI were compared in patients classified according to renal function. For prognosis, in-hospital mortality, 1-year survival rate, overall mortality, and CVD death were investigated. Changes in renal function were also monitored during the follow-up period. The glomerular filtration rate (GFR) was calculated by the Modification of Diet in Renal Disease Study Group (MDRD) formula. Results. The mean estimated GFR (eGFR) at PCI implementation was 66.2 ± 21.0 ml/min/1.73 m2. Stage 2 CKD was shown in 51.5% of all the patients. During the overall follow-up period, 126 patients died. With the progression of CKD stage, all-cause, CVD, and in-hospital mortality increased, and the 1-year survival rate decreased. It was proved that a medical history of hypertension, hyperlipidemia, and diabetes, multiple vessel lesions, hypoalbuminemia, C-reactive protein (CRP), and estimated GFR were independent risk factors for all-cause death. In CVD death, in addition to the above risk factors, anemia and total cholesterol were also an independent risk factor. Renal function deteriorated significantly during the follow-up period. Conclusions. Patients with ischemic heart disease requiring PCI often develop renal dysfunction, which may considerably affect prognosis.

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U2 - 10.1007/s10157-006-0443-6

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