Relationship between serum levels of insulin-like growth factors and subsequent risk of cancer mortality: Findings from a nested case-control study within the Japan Collaborative Cohort Study

Truong Minh Pham, Yoshihisa Fujino, Kei Nakachi, Koji Suzuki, Yoshinori Ito, Yoshiyuki Watanabe, Yutaka Inaba, Kazuo Tajima, Akiko Tamakoshi, Takesumi Yoshimura

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: We investigated the association between serum levels of IGF-I, IGF-II, and IGFBP-3 and the subsequent risk of cancer mortality. Methods: Our case-control study examined samples from 914 cancer deaths and their 2739 matched controls within the Japan Collaborative Cohort Study. Blood samples were obtained at the baseline and stored at -80 °C until analysis for IGF-I, IGF-II, and IGFBP-3 levels. The conditional logistic model was used to estimate odds ratios (ORs) for cancer mortality associated with these serum levels. Results: The adjusted ORs for IGF-I quartiles ranged from 0.81 to 0.96 but were not significant. The adjusted ORs and 95% confidence interval (CI) for the second, third, and fourth IGF-II quartiles were 0.64 (95% CI: 0.52-0.79), 0.71 (95% CI: 0.58-0.88), and 0.73 (95% CI: 0.59-0.91), respectively, while those for the respective IGFBP-3 quartiles were 0.77 (95% CI: 0.63-0.96), 0.75 (95% CI: 0.60-0.94), and 0.71 (95% CI: 0.56-0.90). In the model of IGF-I, and IGF-II additionally adjusted for IGFBP-3, the associations of high IGFs levels were similar as observed in the above models, while the association of IGFBP-3 shifted into non-significance after adjusting for IGF-II. Conclusion: An increased level of IGF-II was significantly associated with decreased risk of cancer mortality, whereas the association between IGF-I and all cancer mortality was not significant. The inverse association of IGFBP-3 level with all cancer mortality was affected when adjusting for IGF-II levels, shifting from significant to non-significant. Confirmation of these results from further cohort studies may aid in identifying the potential association between these molecules and the risk of cancer among the general Japanese population.

Original languageEnglish
Pages (from-to)279-284
Number of pages6
JournalCancer Epidemiology
Volume34
Issue number3
DOIs
Publication statusPublished - 01-06-2010

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Insulin-Like Growth Factor II
Somatomedins
Insulin-Like Growth Factor Binding Protein 3
Case-Control Studies
Japan
Cohort Studies
Insulin-Like Growth Factor I
Confidence Intervals
Mortality
Serum
Neoplasms
Odds Ratio
Logistic Models
Population

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Oncology
  • Cancer Research

Cite this

Pham, Truong Minh ; Fujino, Yoshihisa ; Nakachi, Kei ; Suzuki, Koji ; Ito, Yoshinori ; Watanabe, Yoshiyuki ; Inaba, Yutaka ; Tajima, Kazuo ; Tamakoshi, Akiko ; Yoshimura, Takesumi. / Relationship between serum levels of insulin-like growth factors and subsequent risk of cancer mortality : Findings from a nested case-control study within the Japan Collaborative Cohort Study. In: Cancer Epidemiology. 2010 ; Vol. 34, No. 3. pp. 279-284.
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abstract = "Background: We investigated the association between serum levels of IGF-I, IGF-II, and IGFBP-3 and the subsequent risk of cancer mortality. Methods: Our case-control study examined samples from 914 cancer deaths and their 2739 matched controls within the Japan Collaborative Cohort Study. Blood samples were obtained at the baseline and stored at -80 °C until analysis for IGF-I, IGF-II, and IGFBP-3 levels. The conditional logistic model was used to estimate odds ratios (ORs) for cancer mortality associated with these serum levels. Results: The adjusted ORs for IGF-I quartiles ranged from 0.81 to 0.96 but were not significant. The adjusted ORs and 95{\%} confidence interval (CI) for the second, third, and fourth IGF-II quartiles were 0.64 (95{\%} CI: 0.52-0.79), 0.71 (95{\%} CI: 0.58-0.88), and 0.73 (95{\%} CI: 0.59-0.91), respectively, while those for the respective IGFBP-3 quartiles were 0.77 (95{\%} CI: 0.63-0.96), 0.75 (95{\%} CI: 0.60-0.94), and 0.71 (95{\%} CI: 0.56-0.90). In the model of IGF-I, and IGF-II additionally adjusted for IGFBP-3, the associations of high IGFs levels were similar as observed in the above models, while the association of IGFBP-3 shifted into non-significance after adjusting for IGF-II. Conclusion: An increased level of IGF-II was significantly associated with decreased risk of cancer mortality, whereas the association between IGF-I and all cancer mortality was not significant. The inverse association of IGFBP-3 level with all cancer mortality was affected when adjusting for IGF-II levels, shifting from significant to non-significant. Confirmation of these results from further cohort studies may aid in identifying the potential association between these molecules and the risk of cancer among the general Japanese population.",
author = "Pham, {Truong Minh} and Yoshihisa Fujino and Kei Nakachi and Koji Suzuki and Yoshinori Ito and Yoshiyuki Watanabe and Yutaka Inaba and Kazuo Tajima and Akiko Tamakoshi and Takesumi Yoshimura",
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Relationship between serum levels of insulin-like growth factors and subsequent risk of cancer mortality : Findings from a nested case-control study within the Japan Collaborative Cohort Study. / Pham, Truong Minh; Fujino, Yoshihisa; Nakachi, Kei; Suzuki, Koji; Ito, Yoshinori; Watanabe, Yoshiyuki; Inaba, Yutaka; Tajima, Kazuo; Tamakoshi, Akiko; Yoshimura, Takesumi.

In: Cancer Epidemiology, Vol. 34, No. 3, 01.06.2010, p. 279-284.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Relationship between serum levels of insulin-like growth factors and subsequent risk of cancer mortality

T2 - Findings from a nested case-control study within the Japan Collaborative Cohort Study

AU - Pham, Truong Minh

AU - Fujino, Yoshihisa

AU - Nakachi, Kei

AU - Suzuki, Koji

AU - Ito, Yoshinori

AU - Watanabe, Yoshiyuki

AU - Inaba, Yutaka

AU - Tajima, Kazuo

AU - Tamakoshi, Akiko

AU - Yoshimura, Takesumi

PY - 2010/6/1

Y1 - 2010/6/1

N2 - Background: We investigated the association between serum levels of IGF-I, IGF-II, and IGFBP-3 and the subsequent risk of cancer mortality. Methods: Our case-control study examined samples from 914 cancer deaths and their 2739 matched controls within the Japan Collaborative Cohort Study. Blood samples were obtained at the baseline and stored at -80 °C until analysis for IGF-I, IGF-II, and IGFBP-3 levels. The conditional logistic model was used to estimate odds ratios (ORs) for cancer mortality associated with these serum levels. Results: The adjusted ORs for IGF-I quartiles ranged from 0.81 to 0.96 but were not significant. The adjusted ORs and 95% confidence interval (CI) for the second, third, and fourth IGF-II quartiles were 0.64 (95% CI: 0.52-0.79), 0.71 (95% CI: 0.58-0.88), and 0.73 (95% CI: 0.59-0.91), respectively, while those for the respective IGFBP-3 quartiles were 0.77 (95% CI: 0.63-0.96), 0.75 (95% CI: 0.60-0.94), and 0.71 (95% CI: 0.56-0.90). In the model of IGF-I, and IGF-II additionally adjusted for IGFBP-3, the associations of high IGFs levels were similar as observed in the above models, while the association of IGFBP-3 shifted into non-significance after adjusting for IGF-II. Conclusion: An increased level of IGF-II was significantly associated with decreased risk of cancer mortality, whereas the association between IGF-I and all cancer mortality was not significant. The inverse association of IGFBP-3 level with all cancer mortality was affected when adjusting for IGF-II levels, shifting from significant to non-significant. Confirmation of these results from further cohort studies may aid in identifying the potential association between these molecules and the risk of cancer among the general Japanese population.

AB - Background: We investigated the association between serum levels of IGF-I, IGF-II, and IGFBP-3 and the subsequent risk of cancer mortality. Methods: Our case-control study examined samples from 914 cancer deaths and their 2739 matched controls within the Japan Collaborative Cohort Study. Blood samples were obtained at the baseline and stored at -80 °C until analysis for IGF-I, IGF-II, and IGFBP-3 levels. The conditional logistic model was used to estimate odds ratios (ORs) for cancer mortality associated with these serum levels. Results: The adjusted ORs for IGF-I quartiles ranged from 0.81 to 0.96 but were not significant. The adjusted ORs and 95% confidence interval (CI) for the second, third, and fourth IGF-II quartiles were 0.64 (95% CI: 0.52-0.79), 0.71 (95% CI: 0.58-0.88), and 0.73 (95% CI: 0.59-0.91), respectively, while those for the respective IGFBP-3 quartiles were 0.77 (95% CI: 0.63-0.96), 0.75 (95% CI: 0.60-0.94), and 0.71 (95% CI: 0.56-0.90). In the model of IGF-I, and IGF-II additionally adjusted for IGFBP-3, the associations of high IGFs levels were similar as observed in the above models, while the association of IGFBP-3 shifted into non-significance after adjusting for IGF-II. Conclusion: An increased level of IGF-II was significantly associated with decreased risk of cancer mortality, whereas the association between IGF-I and all cancer mortality was not significant. The inverse association of IGFBP-3 level with all cancer mortality was affected when adjusting for IGF-II levels, shifting from significant to non-significant. Confirmation of these results from further cohort studies may aid in identifying the potential association between these molecules and the risk of cancer among the general Japanese population.

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