TY - JOUR
T1 - Relationship between Serum Levels of Superoxide Dismutase Activity and Subsequent Risk of Lung Cancer Mortality
T2 - Findings from a Nested Case-control Study within the Japan Collaborative Cohort Study
AU - Pham, Truong Minh
AU - Fujino, Yoshihisa
AU - Ando, Masahiko
AU - Suzuki, Koji
AU - Nakachi, Kei
AU - Ito, Yoshinori
AU - Watanabe, Yoshiyuki
AU - Inaba, Yutaka
AU - Tajima, Kazuo
AU - Tamakoshi, Akiko
AU - Yoshimura, Takesumi
AU - Mori, Mitsuru
AU - Sakauchi, Fumio
AU - Motohashi, Yutaka
AU - Tsuji, Ichiro
AU - Nakamura, Yosikazu
AU - Iso, Hiroyasu
AU - Mikami, Haruo
AU - Kurosawa, Michiko
AU - Hoshiyama, Yoshiharu
AU - Tanabe, Naohito
AU - Tamakoshi, Koji
AU - Wakai, Kenji
AU - Tokudome, Shinkan
AU - Hashimoto, Shuji
AU - Kikuchi, Shogo
AU - Wada, Yasuhiko
AU - Kawamura, Takashi
AU - Watanabe, Yoshiyuki
AU - Ozasa, Kotaro
AU - Miki, Tsuneharu
AU - Date, Chigusa
AU - Sakata, Kiyomi
AU - Kurozawa, Yoichi
AU - Yoshimura, Takesumi
AU - Shibata, Akira
AU - Okamoto, Naoyuki
AU - Shio, Hideo
PY - 2009/12
Y1 - 2009/12
N2 - The expression of superoxide dismutases (SODs) has been shown to differ between lung tumor and tumorfree tissues. In the present study, we investigated the association between serum SOD activity and the risk of lung cancer mortality, based on a nested case-control design study within the Japan Collaborative Cohort Study, with a sample of 193 lung cancer patients and 573 matched controls. Blood samples were obtained at the baseline and stored at -80oC until analysis for SOD levels. Serum levels of SODs were divided into quartiles, with the first quartile used as the reference. A conditional logistic model was used to estimate odds ratios (ORs) for lung cancer mortality associated with serum SOD quartile levels. The adjusted ORs and 95% CIs for the second, third; and fourth SOD quartiles were 0.80 (95%CI: 0.49-1.29), 1.32 (0.78-2.25), and 1.07 (0.60-1.89), respectively. In analyses stratified by observation period, the adjusted ORs of the respective quartiles were 0.56 (95%CI: 0.30-1.07), 1.16 (0.57-2.37), and 1.11 (0.52-2.35) for the period from the baseline to 1994; and the adjusted ORs of 1.36 (95%CI: 0.65-2.85), 1.71 (0.75-3.87), and 1.06 (0.44-2.53) for the period after 1994. To conclude, we found no significant association between serum SOD level and the risk of deaths from lung cancer in the present study.
AB - The expression of superoxide dismutases (SODs) has been shown to differ between lung tumor and tumorfree tissues. In the present study, we investigated the association between serum SOD activity and the risk of lung cancer mortality, based on a nested case-control design study within the Japan Collaborative Cohort Study, with a sample of 193 lung cancer patients and 573 matched controls. Blood samples were obtained at the baseline and stored at -80oC until analysis for SOD levels. Serum levels of SODs were divided into quartiles, with the first quartile used as the reference. A conditional logistic model was used to estimate odds ratios (ORs) for lung cancer mortality associated with serum SOD quartile levels. The adjusted ORs and 95% CIs for the second, third; and fourth SOD quartiles were 0.80 (95%CI: 0.49-1.29), 1.32 (0.78-2.25), and 1.07 (0.60-1.89), respectively. In analyses stratified by observation period, the adjusted ORs of the respective quartiles were 0.56 (95%CI: 0.30-1.07), 1.16 (0.57-2.37), and 1.11 (0.52-2.35) for the period from the baseline to 1994; and the adjusted ORs of 1.36 (95%CI: 0.65-2.85), 1.71 (0.75-3.87), and 1.06 (0.44-2.53) for the period after 1994. To conclude, we found no significant association between serum SOD level and the risk of deaths from lung cancer in the present study.
UR - http://www.scopus.com/inward/record.url?scp=77957329685&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77957329685&partnerID=8YFLogxK
M3 - Article
C2 - 20553085
AN - SCOPUS:77957329685
VL - 10
SP - 75
EP - 80
JO - Asian Pacific Journal of Cancer Prevention
JF - Asian Pacific Journal of Cancer Prevention
SN - 1513-7368
IS - SUPPL.1
ER -