Relationship between Serum Levels of Superoxide Dismutase Activity and Subsequent Risk of Cancer Mortality: Findings from a Nested Case-control Study within the Japan Collaborative Cohort Study

Truong Minh Pham, Yoshihisa Fujino, Kei Nakachi, Koji Suzuki, Yoshinori Ito, Yoshiyuki Watanabe, Yutaka Inaba, Kazuo Tajima, Akiko Tamakoshi, Takesumi Yoshimura, Mitsuru Mori, Fumio Sakauchi, Yutaka Motohashi, Ichiro Tsuji, Yosikazu Nakamura, Hiroyasu Iso, Haruo Mikami, Michiko Kurosawa, Yoshiharu Hoshiyama, Naohito TanabeKoji Tamakoshi, Kenji Wakai, Shinkan Tokudome, Shuji Hashimoto, Shogo Kikuchi, Yasuhiko Wada, Takashi Kawamura, Yoshiyuki Watanabe, Kotaro Ozasa, Tsuneharu Miki, Chigusa Date, Kiyomi Sakata, Yoichi Kurozawa, Takesumi Yoshimura, Akira Shibata, Naoyuki Okamoto, Hideo Shio

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Superoxide dismutases (SODs) are antioxidant enzymes that play a role in the defense system of the body. They may be involved in protection against carcinogenesis processes. In the present study, we investigate the association between serum SOD activity and the risk of deaths due to all cancers combined, based on a nested case-control study within the Japan Collaborative Cohort Study of 914 cancer deaths and 2,739 matched controls. Blood samples were obtained at the baseline and stored at -80oC until analysis for SOD levels. Serum levels of SODs were divided into quartiles, with the first quartile used as the reference. A conditional logistic model was used to estimate odds ratios (ORs) for total cancer mortality associated with serum SOD quartile levels. The adjusted ORs and 95% confidence intervals (CIs) for the second, third and fourth SOD quartiles were 0.96 (95%CI: 0.77-1.19), 1.18 (0.92-1.51), and 1.32 (1.04-1.69), respectively. In analyses stratified by observation period, the adjusted ORs of the respective quartiles were 0.81 (95%CI: 0.60-1.08), 0.98 (0.70-1.37), and 1.28 (0.92-1.79) for the period from the baseline to 1994; and the adjusted ORs were 1.18 (95%CI: 0.85-1.63), 1.47 (1.04-2.10), and 1.41 (1.00-2.04) for the period after 1994. To conclude, we found a slightly positive association between serum SOD level and the risk of all cancer mortality in the present study. Elevated serum SOD levels might reflect a response to oxidative stress, and then may predict a state of excess reactive oxygen species in the carcinogenesis process. Detailed studies of associations between serum SOD levels and cancers in specific sites should now be performed, with attention to particular tumour types.

Original languageEnglish
Pages (from-to)69-74
Number of pages6
JournalAsian Pacific Journal of Cancer Prevention
Volume10
Issue numberSUPPL.1
Publication statusPublished - 01-01-2009

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Superoxide Dismutase
Case-Control Studies
Japan
Cohort Studies
Mortality
Serum
Neoplasms
Odds Ratio
Confidence Intervals
Carcinogenesis
Reactive Oxygen Species
Oxidative Stress
Antioxidants
Logistic Models
Observation
Enzymes

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Oncology
  • Public Health, Environmental and Occupational Health
  • Cancer Research

Cite this

Pham, Truong Minh ; Fujino, Yoshihisa ; Nakachi, Kei ; Suzuki, Koji ; Ito, Yoshinori ; Watanabe, Yoshiyuki ; Inaba, Yutaka ; Tajima, Kazuo ; Tamakoshi, Akiko ; Yoshimura, Takesumi ; Mori, Mitsuru ; Sakauchi, Fumio ; Motohashi, Yutaka ; Tsuji, Ichiro ; Nakamura, Yosikazu ; Iso, Hiroyasu ; Mikami, Haruo ; Kurosawa, Michiko ; Hoshiyama, Yoshiharu ; Tanabe, Naohito ; Tamakoshi, Koji ; Wakai, Kenji ; Tokudome, Shinkan ; Hashimoto, Shuji ; Kikuchi, Shogo ; Wada, Yasuhiko ; Kawamura, Takashi ; Watanabe, Yoshiyuki ; Ozasa, Kotaro ; Miki, Tsuneharu ; Date, Chigusa ; Sakata, Kiyomi ; Kurozawa, Yoichi ; Yoshimura, Takesumi ; Shibata, Akira ; Okamoto, Naoyuki ; Shio, Hideo. / Relationship between Serum Levels of Superoxide Dismutase Activity and Subsequent Risk of Cancer Mortality : Findings from a Nested Case-control Study within the Japan Collaborative Cohort Study. In: Asian Pacific Journal of Cancer Prevention. 2009 ; Vol. 10, No. SUPPL.1. pp. 69-74.
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title = "Relationship between Serum Levels of Superoxide Dismutase Activity and Subsequent Risk of Cancer Mortality: Findings from a Nested Case-control Study within the Japan Collaborative Cohort Study",
abstract = "Superoxide dismutases (SODs) are antioxidant enzymes that play a role in the defense system of the body. They may be involved in protection against carcinogenesis processes. In the present study, we investigate the association between serum SOD activity and the risk of deaths due to all cancers combined, based on a nested case-control study within the Japan Collaborative Cohort Study of 914 cancer deaths and 2,739 matched controls. Blood samples were obtained at the baseline and stored at -80oC until analysis for SOD levels. Serum levels of SODs were divided into quartiles, with the first quartile used as the reference. A conditional logistic model was used to estimate odds ratios (ORs) for total cancer mortality associated with serum SOD quartile levels. The adjusted ORs and 95{\%} confidence intervals (CIs) for the second, third and fourth SOD quartiles were 0.96 (95{\%}CI: 0.77-1.19), 1.18 (0.92-1.51), and 1.32 (1.04-1.69), respectively. In analyses stratified by observation period, the adjusted ORs of the respective quartiles were 0.81 (95{\%}CI: 0.60-1.08), 0.98 (0.70-1.37), and 1.28 (0.92-1.79) for the period from the baseline to 1994; and the adjusted ORs were 1.18 (95{\%}CI: 0.85-1.63), 1.47 (1.04-2.10), and 1.41 (1.00-2.04) for the period after 1994. To conclude, we found a slightly positive association between serum SOD level and the risk of all cancer mortality in the present study. Elevated serum SOD levels might reflect a response to oxidative stress, and then may predict a state of excess reactive oxygen species in the carcinogenesis process. Detailed studies of associations between serum SOD levels and cancers in specific sites should now be performed, with attention to particular tumour types.",
author = "Pham, {Truong Minh} and Yoshihisa Fujino and Kei Nakachi and Koji Suzuki and Yoshinori Ito and Yoshiyuki Watanabe and Yutaka Inaba and Kazuo Tajima and Akiko Tamakoshi and Takesumi Yoshimura and Mitsuru Mori and Fumio Sakauchi and Yutaka Motohashi and Ichiro Tsuji and Yosikazu Nakamura and Hiroyasu Iso and Haruo Mikami and Michiko Kurosawa and Yoshiharu Hoshiyama and Naohito Tanabe and Koji Tamakoshi and Kenji Wakai and Shinkan Tokudome and Shuji Hashimoto and Shogo Kikuchi and Yasuhiko Wada and Takashi Kawamura and Yoshiyuki Watanabe and Kotaro Ozasa and Tsuneharu Miki and Chigusa Date and Kiyomi Sakata and Yoichi Kurozawa and Takesumi Yoshimura and Akira Shibata and Naoyuki Okamoto and Hideo Shio",
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month = "1",
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journal = "Asian Pacific Journal of Cancer Prevention",
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Pham, TM, Fujino, Y, Nakachi, K, Suzuki, K, Ito, Y, Watanabe, Y, Inaba, Y, Tajima, K, Tamakoshi, A, Yoshimura, T, Mori, M, Sakauchi, F, Motohashi, Y, Tsuji, I, Nakamura, Y, Iso, H, Mikami, H, Kurosawa, M, Hoshiyama, Y, Tanabe, N, Tamakoshi, K, Wakai, K, Tokudome, S, Hashimoto, S, Kikuchi, S, Wada, Y, Kawamura, T, Watanabe, Y, Ozasa, K, Miki, T, Date, C, Sakata, K, Kurozawa, Y, Yoshimura, T, Shibata, A, Okamoto, N & Shio, H 2009, 'Relationship between Serum Levels of Superoxide Dismutase Activity and Subsequent Risk of Cancer Mortality: Findings from a Nested Case-control Study within the Japan Collaborative Cohort Study', Asian Pacific Journal of Cancer Prevention, vol. 10, no. SUPPL.1, pp. 69-74.

Relationship between Serum Levels of Superoxide Dismutase Activity and Subsequent Risk of Cancer Mortality : Findings from a Nested Case-control Study within the Japan Collaborative Cohort Study. / Pham, Truong Minh; Fujino, Yoshihisa; Nakachi, Kei; Suzuki, Koji; Ito, Yoshinori; Watanabe, Yoshiyuki; Inaba, Yutaka; Tajima, Kazuo; Tamakoshi, Akiko; Yoshimura, Takesumi; Mori, Mitsuru; Sakauchi, Fumio; Motohashi, Yutaka; Tsuji, Ichiro; Nakamura, Yosikazu; Iso, Hiroyasu; Mikami, Haruo; Kurosawa, Michiko; Hoshiyama, Yoshiharu; Tanabe, Naohito; Tamakoshi, Koji; Wakai, Kenji; Tokudome, Shinkan; Hashimoto, Shuji; Kikuchi, Shogo; Wada, Yasuhiko; Kawamura, Takashi; Watanabe, Yoshiyuki; Ozasa, Kotaro; Miki, Tsuneharu; Date, Chigusa; Sakata, Kiyomi; Kurozawa, Yoichi; Yoshimura, Takesumi; Shibata, Akira; Okamoto, Naoyuki; Shio, Hideo.

In: Asian Pacific Journal of Cancer Prevention, Vol. 10, No. SUPPL.1, 01.01.2009, p. 69-74.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Relationship between Serum Levels of Superoxide Dismutase Activity and Subsequent Risk of Cancer Mortality

T2 - Findings from a Nested Case-control Study within the Japan Collaborative Cohort Study

AU - Pham, Truong Minh

AU - Fujino, Yoshihisa

AU - Nakachi, Kei

AU - Suzuki, Koji

AU - Ito, Yoshinori

AU - Watanabe, Yoshiyuki

AU - Inaba, Yutaka

AU - Tajima, Kazuo

AU - Tamakoshi, Akiko

AU - Yoshimura, Takesumi

AU - Mori, Mitsuru

AU - Sakauchi, Fumio

AU - Motohashi, Yutaka

AU - Tsuji, Ichiro

AU - Nakamura, Yosikazu

AU - Iso, Hiroyasu

AU - Mikami, Haruo

AU - Kurosawa, Michiko

AU - Hoshiyama, Yoshiharu

AU - Tanabe, Naohito

AU - Tamakoshi, Koji

AU - Wakai, Kenji

AU - Tokudome, Shinkan

AU - Hashimoto, Shuji

AU - Kikuchi, Shogo

AU - Wada, Yasuhiko

AU - Kawamura, Takashi

AU - Watanabe, Yoshiyuki

AU - Ozasa, Kotaro

AU - Miki, Tsuneharu

AU - Date, Chigusa

AU - Sakata, Kiyomi

AU - Kurozawa, Yoichi

AU - Yoshimura, Takesumi

AU - Shibata, Akira

AU - Okamoto, Naoyuki

AU - Shio, Hideo

PY - 2009/1/1

Y1 - 2009/1/1

N2 - Superoxide dismutases (SODs) are antioxidant enzymes that play a role in the defense system of the body. They may be involved in protection against carcinogenesis processes. In the present study, we investigate the association between serum SOD activity and the risk of deaths due to all cancers combined, based on a nested case-control study within the Japan Collaborative Cohort Study of 914 cancer deaths and 2,739 matched controls. Blood samples were obtained at the baseline and stored at -80oC until analysis for SOD levels. Serum levels of SODs were divided into quartiles, with the first quartile used as the reference. A conditional logistic model was used to estimate odds ratios (ORs) for total cancer mortality associated with serum SOD quartile levels. The adjusted ORs and 95% confidence intervals (CIs) for the second, third and fourth SOD quartiles were 0.96 (95%CI: 0.77-1.19), 1.18 (0.92-1.51), and 1.32 (1.04-1.69), respectively. In analyses stratified by observation period, the adjusted ORs of the respective quartiles were 0.81 (95%CI: 0.60-1.08), 0.98 (0.70-1.37), and 1.28 (0.92-1.79) for the period from the baseline to 1994; and the adjusted ORs were 1.18 (95%CI: 0.85-1.63), 1.47 (1.04-2.10), and 1.41 (1.00-2.04) for the period after 1994. To conclude, we found a slightly positive association between serum SOD level and the risk of all cancer mortality in the present study. Elevated serum SOD levels might reflect a response to oxidative stress, and then may predict a state of excess reactive oxygen species in the carcinogenesis process. Detailed studies of associations between serum SOD levels and cancers in specific sites should now be performed, with attention to particular tumour types.

AB - Superoxide dismutases (SODs) are antioxidant enzymes that play a role in the defense system of the body. They may be involved in protection against carcinogenesis processes. In the present study, we investigate the association between serum SOD activity and the risk of deaths due to all cancers combined, based on a nested case-control study within the Japan Collaborative Cohort Study of 914 cancer deaths and 2,739 matched controls. Blood samples were obtained at the baseline and stored at -80oC until analysis for SOD levels. Serum levels of SODs were divided into quartiles, with the first quartile used as the reference. A conditional logistic model was used to estimate odds ratios (ORs) for total cancer mortality associated with serum SOD quartile levels. The adjusted ORs and 95% confidence intervals (CIs) for the second, third and fourth SOD quartiles were 0.96 (95%CI: 0.77-1.19), 1.18 (0.92-1.51), and 1.32 (1.04-1.69), respectively. In analyses stratified by observation period, the adjusted ORs of the respective quartiles were 0.81 (95%CI: 0.60-1.08), 0.98 (0.70-1.37), and 1.28 (0.92-1.79) for the period from the baseline to 1994; and the adjusted ORs were 1.18 (95%CI: 0.85-1.63), 1.47 (1.04-2.10), and 1.41 (1.00-2.04) for the period after 1994. To conclude, we found a slightly positive association between serum SOD level and the risk of all cancer mortality in the present study. Elevated serum SOD levels might reflect a response to oxidative stress, and then may predict a state of excess reactive oxygen species in the carcinogenesis process. Detailed studies of associations between serum SOD levels and cancers in specific sites should now be performed, with attention to particular tumour types.

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