TY - JOUR
T1 - Relationship between Serum Levels of Superoxide Dismutase Activity and Subsequent Risk of Cancer Mortality
T2 - Findings from a Nested Case-control Study within the Japan Collaborative Cohort Study
AU - Pham, Truong Minh
AU - Fujino, Yoshihisa
AU - Nakachi, Kei
AU - Suzuki, Koji
AU - Ito, Yoshinori
AU - Watanabe, Yoshiyuki
AU - Inaba, Yutaka
AU - Tajima, Kazuo
AU - Tamakoshi, Akiko
AU - Yoshimura, Takesumi
AU - Mori, Mitsuru
AU - Sakauchi, Fumio
AU - Motohashi, Yutaka
AU - Tsuji, Ichiro
AU - Nakamura, Yosikazu
AU - Iso, Hiroyasu
AU - Mikami, Haruo
AU - Kurosawa, Michiko
AU - Hoshiyama, Yoshiharu
AU - Tanabe, Naohito
AU - Tamakoshi, Koji
AU - Wakai, Kenji
AU - Tokudome, Shinkan
AU - Hashimoto, Shuji
AU - Kikuchi, Shogo
AU - Wada, Yasuhiko
AU - Kawamura, Takashi
AU - Watanabe, Yoshiyuki
AU - Ozasa, Kotaro
AU - Miki, Tsuneharu
AU - Date, Chigusa
AU - Sakata, Kiyomi
AU - Kurozawa, Yoichi
AU - Yoshimura, Takesumi
AU - Shibata, Akira
AU - Okamoto, Naoyuki
AU - Shio, Hideo
PY - 2009/12
Y1 - 2009/12
N2 - Superoxide dismutases (SODs) are antioxidant enzymes that play a role in the defense system of the body. They may be involved in protection against carcinogenesis processes. In the present study, we investigate the association between serum SOD activity and the risk of deaths due to all cancers combined, based on a nested case-control study within the Japan Collaborative Cohort Study of 914 cancer deaths and 2,739 matched controls. Blood samples were obtained at the baseline and stored at -80oC until analysis for SOD levels. Serum levels of SODs were divided into quartiles, with the first quartile used as the reference. A conditional logistic model was used to estimate odds ratios (ORs) for total cancer mortality associated with serum SOD quartile levels. The adjusted ORs and 95% confidence intervals (CIs) for the second, third and fourth SOD quartiles were 0.96 (95%CI: 0.77-1.19), 1.18 (0.92-1.51), and 1.32 (1.04-1.69), respectively. In analyses stratified by observation period, the adjusted ORs of the respective quartiles were 0.81 (95%CI: 0.60-1.08), 0.98 (0.70-1.37), and 1.28 (0.92-1.79) for the period from the baseline to 1994; and the adjusted ORs were 1.18 (95%CI: 0.85-1.63), 1.47 (1.04-2.10), and 1.41 (1.00-2.04) for the period after 1994. To conclude, we found a slightly positive association between serum SOD level and the risk of all cancer mortality in the present study. Elevated serum SOD levels might reflect a response to oxidative stress, and then may predict a state of excess reactive oxygen species in the carcinogenesis process. Detailed studies of associations between serum SOD levels and cancers in specific sites should now be performed, with attention to particular tumour types.
AB - Superoxide dismutases (SODs) are antioxidant enzymes that play a role in the defense system of the body. They may be involved in protection against carcinogenesis processes. In the present study, we investigate the association between serum SOD activity and the risk of deaths due to all cancers combined, based on a nested case-control study within the Japan Collaborative Cohort Study of 914 cancer deaths and 2,739 matched controls. Blood samples were obtained at the baseline and stored at -80oC until analysis for SOD levels. Serum levels of SODs were divided into quartiles, with the first quartile used as the reference. A conditional logistic model was used to estimate odds ratios (ORs) for total cancer mortality associated with serum SOD quartile levels. The adjusted ORs and 95% confidence intervals (CIs) for the second, third and fourth SOD quartiles were 0.96 (95%CI: 0.77-1.19), 1.18 (0.92-1.51), and 1.32 (1.04-1.69), respectively. In analyses stratified by observation period, the adjusted ORs of the respective quartiles were 0.81 (95%CI: 0.60-1.08), 0.98 (0.70-1.37), and 1.28 (0.92-1.79) for the period from the baseline to 1994; and the adjusted ORs were 1.18 (95%CI: 0.85-1.63), 1.47 (1.04-2.10), and 1.41 (1.00-2.04) for the period after 1994. To conclude, we found a slightly positive association between serum SOD level and the risk of all cancer mortality in the present study. Elevated serum SOD levels might reflect a response to oxidative stress, and then may predict a state of excess reactive oxygen species in the carcinogenesis process. Detailed studies of associations between serum SOD levels and cancers in specific sites should now be performed, with attention to particular tumour types.
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M3 - Article
C2 - 20553086
AN - SCOPUS:77957374087
VL - 10
SP - 69
EP - 74
JO - Asian Pacific Journal of Cancer Prevention
JF - Asian Pacific Journal of Cancer Prevention
SN - 1513-7368
IS - SUPPL.1
ER -